Therapeutic Enzymes: Function and Clinical Implications, Nikolaos Labrou

Автор: Mario D. Cordero; El?sabet Alcocer-G?mez
Название: Inflammasomes: Clinical and Therapeutic Implications
ISBN: 3030077586 ISBN-13(EAN): 9783030077587
Издательство: Springer
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Цена: 139750.00 T
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Описание: The inflammasome is a protein complex composed of an intracellular sensor—typically a Nod-like receptor (NLR), the precursor procaspase-1, and the adaptor ASC. Inflammasome activation leads to the maturation of caspase-1 and the processing of its substrates, IL-1? and IL-18. The inflammasome has been implicated numerous diseases, and blockade of inflammasome-derived IL-1? has beneficial effects on several of these diseases. Different books have been edited about the biology of inflammasomes and about methods to study, however, the implication of this complex in the different diseases and pathological conditions show the need of a book about the clinical implications and therapeutic options. This project will show the context where inflammasomes are being studied and the molecular implications in the medical and clinical contexts. Other important topic of the inflammasomes will be the development of pharmacological inhibitors in order to improve new clinical applications. In this sense, we can find new drugs with inhibitory effects or old drugs with an inhibitory potential effect. There is a need for re-establishing the real benefits of the inflammasome inhibitions in pathological situations and the management of the differents diseases where inflammasomes are implicated.

Автор: Cordero
Название: Inflammasomes: Clinical and Therapeutic Implications
ISBN: 3319893890 ISBN-13(EAN): 9783319893891
Издательство: Springer
Рейтинг:
Цена: 139750.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The inflammasome is a protein complex composed of an intracellular sensor—typically a Nod-like receptor (NLR), the precursor procaspase-1, and the adaptor ASC. Inflammasome activation leads to the maturation of caspase-1 and the processing of its substrates, IL-1? and IL-18. The inflammasome has been implicated numerous diseases, and blockade of inflammasome-derived IL-1? has beneficial effects on several of these diseases. Different books have been edited about the biology of inflammasomes and about methods to study, however, the implication of this complex in the different diseases and pathological conditions show the need of a book about the clinical implications and therapeutic options. This project will show the context where inflammasomes are being studied and the molecular implications in the medical and clinical contexts. Other important topic of the inflammasomes will be the development of pharmacological inhibitors in order to improve new clinical applications. In this sense, we can find new drugs with inhibitory effects or old drugs with an inhibitory potential effect. There is a need for re-establishing the real benefits of the inflammasome inhibitions in pathological situations and the management of the differents diseases where inflammasomes are implicated.

Автор: Jawahar L. Mehta; Pankaj Mathur; Naranjan S. Dhall
Название: Biochemical Basis and Therapeutic Implications of Angiogenesis
ISBN: 3319611143 ISBN-13(EAN): 9783319611143
Издательство: Springer
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Цена: 186330.00 T
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Описание: Leading authorities on the biochemistry of this complex physiological process explain its critical role in human growth and development as well as the pathogenesis of cancer, heart disease, and other morbidities. The book fully updates the current literature.

Автор: Matsumoto Rae R., Bowen Wayne D., Su Tsung-Ping
Название: Sigma Receptors / Chemistry, Cell Biology and Clinical Implications
ISBN: 0387365125 ISBN-13(EAN): 9780387365121
Издательство: Springer
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Цена: 222670.00 T
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Описание: This book provides an update on sigma receptors, and summarizes recent advances in the medicinal chemistry, molecular biology, and cell biology of sigma receptors. It describes the functional effects mediated by these receptors and the potential clinical implications of these actions. This information is put in a historical perspective to help newcomers to the field successfully navigate the confusing early history surrounding these proteins, and provides a launching point from which future studies and research directions can easily be developed. Major advances in our understanding of sigma receptors have been made during the past few years. This book will facilitate exciting new research that could lead to significant advances in the treatment of neurologic, psychiatric, cardiovascular, immunologic, and gastrointestinal disorders through a better understanding of sigma receptors.

Название: Organoselenium Compounds in Biology and Medicine: Synthesis, Biological and Therapeutic Treatments
ISBN: 1788010299 ISBN-13(EAN): 9781788010290
Издательство: Royal Society of Chemistry
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Цена: 252030.00 T
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Описание: This book discusses organoselenium chemistry and biology in the context of its therapeutic potential, taking the reader through synthetic techniques, bioactivity and therapeutic applications

Автор: Natalia Arias
Название: Cytochrome C: Roles and Therapeutic Implications
ISBN: 1536149071 ISBN-13(EAN): 9781536149074
Издательство: Nova Science
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Цена: 182680.00 T
Наличие на складе: Невозможна поставка.
Описание: Cytochrome C: Roles and Therapeutic Implications provides a thoroughly revised, invaluable resource for university students and researchers in the life sciences, medicine and related fields. This esteemed text attempts to organize available information on this topic to help a better understanding of the role of cytochrome c oxidase and its functional interaction with cytochrome c (Cyt c), the network of oxidation-reduction processes of cyt c in the cell with an emphasis on the implications for apoptosis induction and possible roles of cyt c reducing agents as an attractive strategy to improve neurodegenerative pathologies or cancer. In this book, the authors also reviewed the advantages of cytochrome c oxidase histochemistry to disentangle brain substrates underlying different kinds of learning and memory, from memory engram being retrieved with an untrained hippocampus to its power to identify sensory areas in the teleost fish. Finally, the authors will explore different approaches in cell cultures, animal models, and clinical trials to enhance cytochrome c oxidase activity that lead to improve brain respiratory metabolism, namely, methylene blue and photobiomodulation. This volume effectively introduces basic concepts that are followed by more specific applications as the text evolves, providing the potential of cytochrome c to lead a revolution in the way neurodegenerative disorders are treated.

Автор: Martin Morad; Winifred G. Nayler; Stanislav Kazda;
Название: The Calcium Channel: Structure, Function and Implications
ISBN: 3540500618 ISBN-13(EAN): 9783540500612
Издательство: Springer
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Цена: 81050.00 T
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Описание: This is the first book to summarize experimental results from the new, rapidly expanding field of research into the calcium channel in cell membrane. In the last decade it has been established that calcium ions reach their target intracellular system by passing through specialized calcium channels in the membrane.

Автор: Namae Oshiro, Eiko Miyagi
Название: Matrix Metalloproteinases: Biology, Functions & Clinical Implications
ISBN: 1621007898 ISBN-13(EAN): 9781621007890
Издательство: Nova Science
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Цена: 149940.00 T
Наличие на складе: Невозможна поставка.
Описание: System science and engineering is a field that covers a wide spectrum of modern technology. A system can be seen as a collection of entities and their interrelationships, which forms a whole greater than the sum of the entities and interacts with people, organizations, cultures and activities and the interrelationships among them. Systems composed of autonomous subsystems are not new, but the increased complexity of modern technology demands ever more reliable, intelligent, robust and adaptable systems to meet evolving needs. This book presents papers delivered at the International Conference on System Science and Engineering ICSSE2015,

Автор: William Clarke
Название: Clinical Challenges in Therapeutic Drug Monitoring
ISBN: 0128020253 ISBN-13(EAN): 9780128020258
Издательство: Elsevier Science
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Цена: 41530.00 T
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Описание: "

Clinical Challenges in Therapeutic Drug Monitoring: Special Populations, Physiological Conditions and Pharmacogenomic"s focuses on critical issues in therapeutic drug monitoring including special requirements of therapeutic drug monitoring important to special populations (infants and children, pregnant women, elderly patients, and obese patients). The book also covers issues of free drug monitoring and common interferences in using immunoassays for therapeutic drug monitoring.

This book is essential reading for any clinician, fellow, or trainee who wants to gain greater insight into the process of therapeutic drug monitoring for individual dosage adjustment and avoiding drug toxicity for certain drugs within a narrow therapeutic window. The book is written specifically for busy clinicians, fellows, and trainees who order therapeutic drug monitoring and need to get more familiar with testing methodologies, issues of interferences, and interpretation of results in certain patient populations.
Offers busy clinicians, pathologists, and trainees a concise resource on the key aspects and critical issues in therapeutic drug monitoringFocuses on patient populations such as infants and children, pregnant women, elderly patients, and obese patients, who have special requirements in therapeutic drug monitoringExplores special topics in therapeutic drug monitoring including free drug monitoring and common immunoassay interferenceExplains how individual dosage adjustments can prevent drug toxicity for certain drugs within a narrow therapeutic window

Автор: Peplow Philip V., Martinez Bridget, Calin George A.
Название: Micrornas in Diseases and Disorders: Emerging Therapeutic Targets
ISBN: 1788013948 ISBN-13(EAN): 9781788013949
Издательство: Royal Society of Chemistry
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Цена: 325690.00 T
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Описание: MicroRNAs in Diseases and Disorders highlights the role of miRNAs in the development and progression of a variety of diseases and the utilization of miRNA targets in treatment. This book also includes the use of miRNAs as diagnostic and prognostic biomarkers for disease.

Автор: Peggy L. Carver
Название: Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic
ISBN: 3110526913 ISBN-13(EAN): 9783110526912
Издательство: Walter de Gruyter
Цена: 272730.00 T
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Описание: Volume 19, entitled Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic of the series Metal Ions in Life Sciences centers on the role of metal ions in clinical medicine. Metal ions are tightly regulated in human health: while essential to life, they can be toxic as well. Following an introductory chapter briefly discussing several important metal-related drugs and diseases and a chapter about drug development, the focus is fi rst on iron: its essentiality for pathogens and humans as well as its toxicity. Chelation therapy is addressed in the context of thalassemia, its relationship to neurodegenerative diseases and also the risks connected with iron administration are pointed out. A subject of intense debate is the essentiality of chromium and vanadium. For example, chromium(III) compounds are taken as a nutritional supplement by athletes and bodybuilders; in contrast, chromate, Cr(VI), is toxic and a carcinogen for humans. The benefi cial and toxic effects of manganese, cobalt, and copper on humans are discussed. The need for antiparasitic agents is emphasized as well as the clinical aspects of metal-containing antidotes for cyanide poisoning. In addition to the essential and possibly essential ones, also other metal ions play important roles in human health, causing harm (like the metalloid arsenic, lead or cadmium) or being used in diagnosis or treatment of human diseases, like gadolinium, gallium, lithium, gold, silver or platinum. The impact of this vibrant research area on metals in the clinic is provided in 14 stimulating chapters, written by internationally recognized experts from the Americas, Europe and China, and is manifested by approximately 2000 references, and about 90 illustrations and tables. Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic is an essential resource for scientists working in the wide range from pharmacology, enzymology, material sciences, analytical, organic, and inorganic biochemistry all the way through to medicine ... not forgetting that it also provides excellent information for teaching.

Автор: Jian Wu
Название: Cytochrome P450 Enzymes: Biochemistry, Pharmacology & Health Implications
ISBN: 1619422093 ISBN-13(EAN): 9781619422094
Издательство: Nova Science
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Цена: 224920.00 T
Наличие на складе: Невозможна поставка.
Описание: Cytochrome P450 (CYP) is a super family of phase I enzyme in the biotransformation of xenobiotics and medications. Most medications undergo deactivation by CYP, and then are eliminated through either bile or kidneys from the body. CYP isozymes play a crucial role in drug interactions that may result in enhanced toxicity, reduced efficacy or onset of adverse reactions. On the other hand, many agents affecting CYP expression and activity may alter metabolic rate of different medications co-administrated. Therefore, the molecular basis, regulation by inducers or inhibitors, and pharmacologic reaction of specific CYP isozymes are the key issues of biochemical mechanisms, pharmaceutical development and safe use of various medications. This book is to meet the needs from basic molecular biochemists, pharmacologists, pharmacists, medical students, clinical practitioners and scientists, as well as broad readers who wish to understand how an herbal extract, medication or natural supplement is metabolized or transformed in the liver or other sites for deactivation and elimination. Special focuses are paid to herbal extracts and medications in the treatment of neuro-psychiatric or cardiovascular disorders, diabetes and viral hepatitis. Detailed dissection of drug interactions in a particular field intends to provide rationales for useful guidance of safe drug use in daily practice. The contributing authors are basic scientists, pharmacists, pharmacologists and on-service physicians in cardiovascular, neuro-psychiatric, gastroenterologic and hepatologic fields from Europe (Germany, France, Portugal), Australia, the US and China. Thus, the book is the collection of master pieces by well-known experts from various regions of the world, and represents the current understanding of CYP enzyme reaction and a contemporary coverage of possible drug interactions in involved fields. The featured chapters are scientific elucidation of basic biochemistry, pharmacology and clinical investigations in the interest of drug metabolism, interaction and safe use guidance in the single focus of this microsomal enzyme with multi-facet metabolic function.