Inflammasomes: Clinical and Therapeutic Implications, Mario D. Cordero; El?sabet Alcocer-G?mez

Автор: Jawahar L. Mehta; Pankaj Mathur; Naranjan S. Dhall
Название: Biochemical Basis and Therapeutic Implications of Angiogenesis
ISBN: 3319611143 ISBN-13(EAN): 9783319611143
Издательство: Springer
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Цена: 186330.00 T
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Описание: Leading authorities on the biochemistry of this complex physiological process explain its critical role in human growth and development as well as the pathogenesis of cancer, heart disease, and other morbidities. The book fully updates the current literature.

Автор: Cordero
Название: Inflammasomes: Clinical and Therapeutic Implications
ISBN: 3319893890 ISBN-13(EAN): 9783319893891
Издательство: Springer
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Цена: 139750.00 T
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Описание: The inflammasome is a protein complex composed of an intracellular sensor—typically a Nod-like receptor (NLR), the precursor procaspase-1, and the adaptor ASC. Inflammasome activation leads to the maturation of caspase-1 and the processing of its substrates, IL-1? and IL-18. The inflammasome has been implicated numerous diseases, and blockade of inflammasome-derived IL-1? has beneficial effects on several of these diseases. Different books have been edited about the biology of inflammasomes and about methods to study, however, the implication of this complex in the different diseases and pathological conditions show the need of a book about the clinical implications and therapeutic options. This project will show the context where inflammasomes are being studied and the molecular implications in the medical and clinical contexts. Other important topic of the inflammasomes will be the development of pharmacological inhibitors in order to improve new clinical applications. In this sense, we can find new drugs with inhibitory effects or old drugs with an inhibitory potential effect. There is a need for re-establishing the real benefits of the inflammasome inhibitions in pathological situations and the management of the differents diseases where inflammasomes are implicated.

Автор: Isabelle Couillin; Virginie P?trilli; Fabio Martin
Название: The Inflammasomes
ISBN: 3034803435 ISBN-13(EAN): 9783034803434
Издательство: Springer
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Цена: 174130.00 T
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Описание: Including a range of contributions from numerous leading international experts in the field, this book provides an extensive overview of the current knowledge of inflammasome biology as well as analyzing the role they play in both health and disease.

Автор: Sohn, Jungsan
Название: Dna Sensors And Inflammasomes,625
ISBN: 0128183594 ISBN-13(EAN): 9780128183595
Издательство: Elsevier Science
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Цена: 154960.00 T
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Описание:

DNA Sensors and Inflammasomes, Volume 625, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. New sections in this release include Phosphorylation and dimerization of STING and IRF3, cGAS enzymology, Synthesis and identification of immuno-stimulatory CDNs, Tracking cGAS activity/ cGAMP formation using SPR/NMR, Using an enzyme coupled assay to track cGAS activity under steady states, Tracking the polymerization of DNA sensors, inflammasome receptors, and downstream signaling partners using FRET, NLRC4 structure, Tracking TREX1 activity, DNA association and dissociation kinetics of PARP1, and more.

Автор: Nikolaos Labrou
Название: Therapeutic Enzymes: Function and Clinical Implications
ISBN: 9811377081 ISBN-13(EAN): 9789811377082
Издательство: Springer
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Цена: 144410.00 T
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Описание: Therapeutic enzymes exhibit fascinating features and opportunities, and represent a significant and promising subcategory of modern biopharmaceuticals for the treatment of several severe diseases. Research and drug developments efforts and the advancements in biotechnology over the past twenty years have greatly assisted the introduction of efficient and safe enzyme-based therapies for a range of both rare and common disorders. The introduction and regulatory approval of twenty different recombinant enzymes has enabled effective enzyme-replacement therapy. This volume aims to overview these therapeutic enzymes, focusing in particular on more recently approved enzymes produced by recombinant DNA technology. This volume is composed of four sections. Section 1 provides an overview of the production process and biochemical characterization of therapeutic enzymes, while Section 2 focuses upon the engineering strategies and delivery methods of therapeutic enzymes. Section 3 highlights the clinical applications of approved therapeutic enzymes, including aspects on their structure, indications and mechanisms of action. Together with information on these mechanisms, safety and immunogenicity issues and various adverse events of the recombinant enzymes used for therapy are discussed. Section 4, provides discussion on the prospective and future developments of new therapeutic enzymes. This book is aimed at academics, researchers and students undertaking advanced undergraduate/postgraduate programs in the biopharmaceutical/biotechnology area who wish to gain a comprehensive understanding of enzyme-based therapeutic molecules.

Автор: Natalia Arias
Название: Cytochrome C: Roles and Therapeutic Implications
ISBN: 1536149071 ISBN-13(EAN): 9781536149074
Издательство: Nova Science
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Цена: 182680.00 T
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Описание: Cytochrome C: Roles and Therapeutic Implications provides a thoroughly revised, invaluable resource for university students and researchers in the life sciences, medicine and related fields. This esteemed text attempts to organize available information on this topic to help a better understanding of the role of cytochrome c oxidase and its functional interaction with cytochrome c (Cyt c), the network of oxidation-reduction processes of cyt c in the cell with an emphasis on the implications for apoptosis induction and possible roles of cyt c reducing agents as an attractive strategy to improve neurodegenerative pathologies or cancer. In this book, the authors also reviewed the advantages of cytochrome c oxidase histochemistry to disentangle brain substrates underlying different kinds of learning and memory, from memory engram being retrieved with an untrained hippocampus to its power to identify sensory areas in the teleost fish. Finally, the authors will explore different approaches in cell cultures, animal models, and clinical trials to enhance cytochrome c oxidase activity that lead to improve brain respiratory metabolism, namely, methylene blue and photobiomodulation. This volume effectively introduces basic concepts that are followed by more specific applications as the text evolves, providing the potential of cytochrome c to lead a revolution in the way neurodegenerative disorders are treated.