Cell-Based Assays Using iPSCs for Drug Development and Testing, Carl-Fredrik Mandenius; James A. Ross

Автор: Carl-Fredrik Mandenius; James A. Ross
Название: Cell-Based Assays Using iPSCs for Drug Development and Testing
ISBN: 1493994794 ISBN-13(EAN): 9781493994793
Издательство: Springer
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Цена: 107130.00 T
Наличие на складе: Нет в наличии.
Описание: The volume presents a variety of protocols that will be useful to researchers working in the field of disease modeling, drug discovery, and the cell biology of various tissues. Chapters in this book cover topics such as requirements and preconditions for using human induced pluripotent cell lines in assay development; the culture of iPSCs and iPSC-derived cardiomyocytes by bioreactor technologies; distinctions between hepatocytes, vascular endothelial cells, cardiomyocytes, renal podocytes, and neurons; and high content assays of mitochondrial function and autophagy. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Cell-Based Assay using iPSCs for Drug Development and Testing: Methods and Protocols is a valuable resource for researchers working in this important and developing field of study.

Автор: Thangaraj Parimelazhagan
Название: Pharmacological Assays of Plant-Based Natural Products
ISBN: 3319268104 ISBN-13(EAN): 9783319268101
Издательство: Springer
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Цена: 130430.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: After a detailed in vitro investigation including nutritional and anti-nutritional analyses, medicinal properties were tested with various in vivo models for anti-inflammatory, analgesic, anti-pyretic, anticancer and anti-diabetic properties, as well as wound healing, neurodegenerative diseases, etc.

Автор: Parimelazhagan Thangaraj
Название: Pharmacological Assays of Plant-Based Natural Products
ISBN: 3319800205 ISBN-13(EAN): 9783319800202
Издательство: Springer
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Цена: 93160.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume provides information on how to select and screen plants for their medicinal properties. It describes phytopharmacological techniques for extracting and qualitatively and quantitatively analyzing a plant’s phytochemicals. After a detailed in vitro investigation including nutritional and anti-nutritional analyses, medicinal properties were tested with various in vivo models for anti-inflammatory, analgesic, anti-pyretic, anticancer and anti-diabetic properties, as well as wound healing, neurodegenerative diseases, etc. Compound identification and purification techniques include, among others, TLC and column chromatography, as well as molecular docking with specific proteins.

Автор: F.A. de Wolff; H. Mattie; D.D. Breimer
Название: Therapeutic Relevance of Drug Assays
ISBN: 9400995857 ISBN-13(EAN): 9789400995857
Издательство: Springer
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Цена: 81050.00 T
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Автор: Mohan C Vemuri; Lucas G. Chase; Mahendra S. Rao
Название: Mesenchymal Stem Cell Assays and Applications
ISBN: 1493957791 ISBN-13(EAN): 9781493957798
Издательство: Springer
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Цена: 130430.00 T
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Описание: This book shows how to propagate, characterize, and engineer this special cell type. Using the Methods in Molecular Biology (TM) format, each chapter offers an introduction, step-by-step methods, materials list, and tips on troubleshooting and avoiding pitfalls.

Автор: Damoiseaux
Название: Reporter Gene Assays
ISBN: 1493977229 ISBN-13(EAN): 9781493977222
Издательство: Springer
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Цена: 93160.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume explores the applications of reporter gene technology and the methodologies needed for their effective implementation.

Автор: Duarte Miguel F. Prazeres; Sofia Aires M. Martins
Название: G Protein-Coupled Receptor Screening Assays
ISBN: 1493923358 ISBN-13(EAN): 9781493923359
Издательство: Springer
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Цена: 130430.00 T
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Описание: This volume explores the considerable efforts that have been directed towards the development of G Protein-Coupled Receptors (GPCR) screening assays in order to disclose GPCR acting compounds, elucidate signaling mechanisms or evaluate compound`s efficacy.

Название: Cell sources for ipscs, volume 7
ISBN: 0128221356 ISBN-13(EAN): 9780128221358
Издательство: Elsevier Science
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Цена: 151590.00 T
Наличие на складе: Нет в наличии.
Описание: The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology. Somatic cells can be reprogrammed into induced pluripotent stem cells (iPSCs) by the expression of specific transcription factors. These cells are transforming biomedical research in the last 15 years. Cell Sources for iPSCs, Volume 7 teaches readers about current advances in the field. It shares up-to-date comprehensive overviews of current advances in the field. This book describes the derivation of iPSCs from different sources in vitro, enabling us to study the cellular and molecular mechanisms involved in different pathologies. Further insights into these mechanisms will have important implications for our understanding of disease appearance, development, and progression. The authors focus on the modern state-of-art methodologies and the leading-edge concepts in the field of stem cell biology. In recent years, remarkable progress has been made in the obtention of iPSCs and their differentiation into several cell types, tissues, and organs using state-of-art techniques. These advantages facilitated identification of key targets and definition of the molecular basis of several disorders. Thus, this book is an attempt to describe the most recent developments in iPSCs biology, which is one of the rising hot topics in the field of molecular and cellular biology today. Here, we present a selected collection of detailed chapters on how we derive iPSCs from distinct sources. Ten chapters written by experts in the field summarize the present knowledge about different cell sources for iPSCs. This volume is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine, and organ transplantation and is contributed by world-renowned authors in the field.

Автор: Birbrair, Alexander
Название: Ipscs Derived Cell Types,10
ISBN: 0128238844 ISBN-13(EAN): 9780128238844
Издательство: Elsevier Science
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Цена: 151590.00 T
Наличие на складе: Нет в наличии.
Описание: The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology. Current Progress in iPSC-derived Cell Types, Volume 10 addresses how induced pluripotent stem cells can be differentiated into different cell types. Somatic cells can be reprogrammed into induced pluripotent stem cells by the expression of specific transcription factors. These cells have been transforming biomedical research over the last 15 years. This volume will address the advances in research of how research of induced pluripotent stem cells can be reprogrammed to develop new treatment technologies in regenerative medicine. The volume is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine and organ transplantation; and is contributed by world-renowned authors in the field.

Название: Ipscs from diverse species
ISBN: 012822228X ISBN-13(EAN): 9780128222287
Издательство: Elsevier Science
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Цена: 153830.00 T
Наличие на складе: Нет в наличии.
Описание: Chemical industries, dairy units, oil and gas refineries, petro-chemical complexes and fertilizer manufacturing units are few of those areas which are incomplete without anti-corrosive treatment for concrete surface. Environmental effects, spillage and dust- emission are few of those processes which can corrode concrete. Protection of concrete surface of constructed elements from corrosive attack "arising through very harsh corrosive conditions" from all those (and many more) sources of corrosion becomes a moral duty of a Civil Engineer. This book is an effort in this direction to share the applied knowledge with the budding Engineers so that they are aware of such protective measures to be taken for the situations they are put into which I am sure, you must have found it to be of significant importance. One save of production stoppage with use of knowledge contained in this book would serve the very purpose of bringing it out.

Автор: Birbrair, Alexander
Название: Recent Advances In Ipscs For Therapy ,9
ISBN: 0128238828 ISBN-13(EAN): 9780128238820
Издательство: Elsevier Science
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Цена: 153830.00 T
Наличие на складе: Нет в наличии.
Описание:

The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology.

Автор: Birbrair, Alexander
Название: Ipscs For Modeling Central Nervous System Disorders,6
ISBN: 0323857647 ISBN-13(EAN): 9780323857642
Издательство: Elsevier Science
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Цена: 153830.00 T
Наличие на складе: Нет в наличии.
Описание: Digital Information Design (DID) is primarily a business information management (BIM) model. As with any model it is used to help you to describe problems and test potential solutions. DID is not like any other method or framework model; it is independent of any other existing model or framework and does not claim to manage the entirety of the design of business information services. DID identifies useful and widely used best practices that are designed specifically for use in any phase of business information service development from idea, conception, specification, design, test, handover, service management and operation, or managing architectural issues or hardware and software installation. Primarily, DID was developed to manage the quality of information, and how to put it to good use. The DID model has been designed for you to identify what you need and when you need it when designing business information services and as a broad guide, identifies key points in existing frameworks that are particularly useful. The model is wholly independent of all other frameworks (including BiSL and BiSL Next in which the basic design is rooted). You can choose and use whatever you wish, the model will help you to assess the validity of your choice(s) and identify strengths and weaknesses in your approach.The DID model focuses on the common languages to describe key elements of design (need and value, mission and capability), key business information perspectives (business, information/data, services and technology) and the high-level domains (governance, strategy, improvement and operation) that must be managed in order to effectively run any business.DID helps you to identify only what you need to ensure that business information design reflects what is needed by your enterprise. The model can be used entirely separately from the framework level guidance discussed and it can be used at any level in the organization. The essentials of DID are explained in two books: this book, Foundation and the Practitioner book that will be published later.