Therapeutic Relevance of Drug Assays, F.A. de Wolff; H. Mattie; D.D. Breimer

Автор: S.R. Walker; C. Lumley; N. McAuslane
Название: The Relevance of Ethnic Factors in the Clinical Evaluation of Medicines
ISBN: 9401046212 ISBN-13(EAN): 9789401046213
Издательство: Springer
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Цена: 46570.00 T
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Описание: The mutual acceptance of foreign clinical data would reduce the time and resources required to develop a new medicine for the international market by eliminating the requirement for the routine repetition of clinical studies in local populations.

Автор: Heinrich Schmidt-Gayk; Franz P. Armbruster; Roger
Название: Calcium Regulating Hormones, Vitamin D Metabolites, and Cyclic AMP Assays and Their Clinical Application
ISBN: 3662004089 ISBN-13(EAN): 9783662004081
Издательство: Springer
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Цена: 93160.00 T
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Описание: Calcium metabolism is regulated by three specific hormones: parathor- mone, calciferol metabolites, and calcitonin. Cyclic AMP also plays an important part in calcium regulation, and its concentration in urine can be taken as a measure of parathyroid function. Methods for quantitative measurement of, e.g. calcium-regulating hormones and vitamin D metabolites as well as of cAMP are absolutely necessary for safe differential diagnosis of diseases of the parathyroid like hypo- and hyperparathyroidism. In this monograph all presently available methods are summarized as to whether they can already be obtained as test kits or are still being tested. Radioimmunoassays for the various peptide fragments such as 53-84, 44-68, 28-48, and 1-34 are described, as are immunochemiluminescence methods and adenylate cyclase bioassays. The same is true for the vitamin D metabolites, where the various assays for calcidiol and calcitriol such as HPLC, protein-binding assay with second antibody separation, and double antibody RIA are de scribed. Finally, determination of calcitonin and cAMP is discussed in detail. This is a practically and clinically oriented monograph for working in the fields of internal medicine, endocrinology, and laboratory medicine.

Автор: Duarte Miguel F. Prazeres; Sofia Aires M. Martins
Название: G Protein-Coupled Receptor Screening Assays
ISBN: 1493923358 ISBN-13(EAN): 9781493923359
Издательство: Springer
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Цена: 130430.00 T
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Описание: This volume explores the considerable efforts that have been directed towards the development of G Protein-Coupled Receptors (GPCR) screening assays in order to disclose GPCR acting compounds, elucidate signaling mechanisms or evaluate compound`s efficacy.

Автор: Thangaraj Parimelazhagan
Название: Pharmacological Assays of Plant-Based Natural Products
ISBN: 3319268104 ISBN-13(EAN): 9783319268101
Издательство: Springer
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Цена: 130430.00 T
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Описание: After a detailed in vitro investigation including nutritional and anti-nutritional analyses, medicinal properties were tested with various in vivo models for anti-inflammatory, analgesic, anti-pyretic, anticancer and anti-diabetic properties, as well as wound healing, neurodegenerative diseases, etc.

Автор: Zhu
Название: High-Throughput Screening Assays in Toxicology
ISBN: 1493963449 ISBN-13(EAN): 9781493963447
Издательство: Springer
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Цена: 121110.00 T
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Описание: This book focuses on recently developed High Throughput Screening (HTS) assay protocols, many involved in the ToxCast and/or Tox21 initiatives, and the relevant HTS data analysis techniques. Divided into three sections, in vitro assays, in vivo assays, and computational techniques to analyze HTS data are all examined. Written for the highly successful Methods in Molecular Biology series, most chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.