Targeting the DNA Damage Response for Anti-Cancer Therapy, John Pollard; Nicola Curtin
Автор: Yosef Yarden; Moshe Elkabets Название: Resistance to Anti-Cancer Therapeutics Targeting Receptor Tyrosine Kinases and Downstream Pathways ISBN: 3319679309 ISBN-13(EAN): 9783319679303 Издательство: Springer Рейтинг: Цена: 149060.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This volume comprehensively covers the multiplicity and diversity of mechanisms underlying patient resistance to currently approved anti-cancer drugs, including tyrosine kinase inhibitors and monoclonal antibodies, blockers of growth factor receptors and their downstream pathways, which play essential functions in cancer progression.
Автор: Lawrence Panasci; Raquel Aloyz; Moulay Alaoui-Jama Название: Advances in DNA Repair in Cancer Therapy ISBN: 1489993088 ISBN-13(EAN): 9781489993083 Издательство: Springer Рейтинг: Цена: 174130.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book details the biological mechanisms by which cancer cells can circumvent anticancer therapy and limits its usefulness in patients. It also reviews the impact of such novel inhibitors of DNA repair mechanisms as methylguanine-DNA-methyltransferase.
Автор: Pollard Название: Targeting the DNA Damage Response for Anti-Cancer Therapy ISBN: 3319758349 ISBN-13(EAN): 9783319758343 Издательство: Springer Рейтинг: Цена: 186330.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: As a result of all these observations there has been a great interest in targeting the DDR to provide anti-cancer agents that may have benefit as monotherapy in cancers with high background DNA damage levels or as a means to increase the efficacy of DNA damaging drugs and IR.
Автор: Kum Kum Khanna; Yosef Shiloh Название: The DNA Damage Response: Implications on Cancer Formation and Treatment ISBN: 940077995X ISBN-13(EAN): 9789400779952 Издательство: Springer Рейтинг: Цена: 174130.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Written by active investigators who have made important contributions in their respective areas, this book offers an up-to-date and comprehensive review of the latest advances in DNA damage sensing, signaling and repair.
Автор: Yang Название: Targeting Autophagy in Cancer Therapy ISBN: 3319427385 ISBN-13(EAN): 9783319427386 Издательство: Springer Рейтинг: Цена: 148020.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This volume will detail the current state and perspectives of autophagy-based cancer therapy. Covering a wide range of topics, it will include an overview of autophagy as a therapeutic target in cancer, autophagy modulators as cancer therapeutic agents, implications of micro-RNA-regulated autophagy in cancer therapy, modulation of autophagy through targeting PI3 kinase in cancer therapy, targeting autophagy in cancer stem cells, and roles of autophagy in cancer immunotherapy. In addition, the volume will review applications of system biology and bioinformatics approaches to discovering cancer therapeutic targets in the autophagy regulatory network. The volume will be beneficial for a variety of basic and clinical scientists, including cancer biologists, autophagy researchers, pharmacologists, and clinical oncologists who wish to delve more deeply into this field of cancer research.This volume will be the first book to focus solely on autophagy as a target in cancer therapy. As well, it will comprehensively discuss the roles of autophagy in most currently available cancer treatments.
Автор: Kelley, Mark R. Название: DNA Repair in Cancer Therapy ISBN: 012803582X ISBN-13(EAN): 9780128035825 Издательство: Elsevier Science Рейтинг: Цена: 124640.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
DNA Repair and Cancer Therapy: Molecular Targets and Clinical Applications, Second Edition provides a comprehensive and timely reference that focuses on the translational and clinical use of DNA repair as a target area for the development of diagnostic biomarkers and the enhancement of cancer treatment.
Experts on DNA repair proteins from all areas of cancer biology research take readers from bench research to new therapeutic approaches. This book provides a detailed discussion of combination therapies, in other words, how the inhibition of repair pathways can be coupled with chemotherapy, radiation, or DNA damaging drugs.
Newer areas in this edition include the role of DNA repair in chemotherapy induced peripheral neuropathy, radiation DNA damage, Fanconi anemia cross-link repair, translesion DNA polymerases, BRCA1-BRCA2 pathway for HR and synthetic lethality, and mechanisms of resistance to clinical PARP inhibitors.
Автор: Yosef Yarden; Moshe Elkabets Название: Resistance to Anti-Cancer Therapeutics Targeting Receptor Tyrosine Kinases and Downstream Pathways ISBN: 3030098176 ISBN-13(EAN): 9783030098179 Издательство: Springer Рейтинг: Цена: 139750.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This volume comprehensively covers the multiplicity and diversity of mechanisms underlying patient resistance to currently approved anti-cancer drugs, including tyrosine kinase inhibitors and monoclonal antibodies, blockers of growth factor receptors and their downstream pathways, which play essential functions in cancer progression. Each chapter will cover a specific group of targets and the cognate drugs, along with molecular modes of innate and evolving resistance.
Автор: Gregory Название: Apoptosis in Cancer Pathogenesis and Anti-cancer Therapy ISBN: 3319394045 ISBN-13(EAN): 9783319394046 Издательство: Springer Рейтинг: Цена: 158380.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
This book discusses properties of apoptosis and other cell death modalities in cancer pathogenesis and treatment. Its nine chapters discuss modulation of anti-tumor inflammatory and immune responses, effects on the tumor microenvironment, to strategies for improving pro-apoptotic therapies, mechanisms and implications for disease pathogenesis, axl and mer receptor tyrosine kinases, immunogenic apoptotic cell death and anti-cancer immunity and cancer cell death-inducing radiotherapy. This book places the onco-biology of apoptosis in clear and objective perspective through an expertly synthesized series of reviews.
Apoptosis in Cancer Pathogenesis and Anti-cancer Therapy is a deft and thorough exploration of cutting-edge research in apoptosis and anti-cancer mechanisms from basic biology to oncology. It highlights a rapidly growing field within cancer research and is essential reading for oncologists, biochemists and advanced graduate students alike.
Targeting Cell Survival Pathways to Enhance Response to Chemotherapy encompasses recently developed molecular targeting agents and approaches that suppress cell survival signaling. Cell survival signaling attenuates the effectiveness of conventional chemotherapy and numerous mechanisms have been described, and continue to be described, which contribute to cell survival in the face of chemotherapy treatment.
Key pathways leading to chemoresistance emanate from growth factor receptors, PI3K, STAT3, anti-apoptotic Bcl-2 family members, autophagy, and the DNA damage response pathway. New advances have underscored the potential of targeting each of these cell survival mechanisms to improve responsiveness to chemotherapy. This book reviews these recent advances and provides a foundational background and hints of new opportunities for basic, translational, and clinical investigators focused on improving therapeutic responses to chemotherapy.
Автор: Andrey S. Bryukhovetskiy Название: Clinical Oncoproteomics: Proteome-Based Personalized Anti-Cancer Therapy ISBN: 1536144770 ISBN-13(EAN): 9781536144772 Издательство: Nova Science Рейтинг: Цена: 215410.00 T Наличие на складе: Невозможна поставка. Описание: This monograph is dedicated to the issues of clinical oncoproteomics, its role and place in contemporary medicine in general, and in particular, oncology. This book reviews various academic viewpoints on the informational component and value of the data of clinical oncoproteomics for the diagnostics and treatment of malignant tumors using cellular, genomic and post-genomic technologies. The monograph summarizes modern concepts of carcinogenesis and describes the authors informational theory of cancer onset. The book presents theoretical, methodological and technical aspects of the innovative medical technology of the personalized proteome-based cell therapy of neoplasms. The author describes his own experience in mapping, proteomic and transcriptomic profiling of the postnatal regional progenitors and cancer stem cells of cancer patients, and the methods of bioinformational processing and mathematical modeling of the results. This book also demonstrates mathematical instruments that are used to detect the regulatory targets of the proliferative and reproductive functions of cancer stem cells in tumors and production of the targeted individually tailored anti-cancer proteome-based cell products. The mechanisms, limitations and future of these technologies are examined relying on the evidence of the clinical proteomics. This book is intended for a broad range of specialists, including clinical doctors of different specializations, such as oncologists, surgeons, neurologists, neurosurgeons, intensivists, immunologists, biochemists, molecular biologists, geneticians, professors and students of medical colleges, as well as specialists working with the issues of cell therapy and personalized medicine.
Автор: Moshe Szyf Название: DNA Methylation and Cancer Therapy ISBN: 1441934162 ISBN-13(EAN): 9781441934161 Издательство: Springer Рейтинг: Цена: 213360.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Once techniques to probe the methylation profile of whole genomes as well as specific genes became available, it became clear that DNA methylation patterns are gene and tissue specific and that patterns of gene expression correlate with patterns of methylation.
Автор: Eleonora Patsenker Название: Integrin Targeting Systems for Tumor Diagnosis and Therapy ISBN: 1493974432 ISBN-13(EAN): 9781493974436 Издательство: Springer Рейтинг: Цена: 121110.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This volume collects a variety of techniques and methodologies developed to facilitate research on integrin biology and to identify ideal targets and approaches for the treatment of multiple organ diseases, with a focus on cancer in particular.
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