Biomarkers of the Tumor Microenvironment, Lars A. Akslen; Randolph S. Watnick
Автор: Ursini-Siegel Название: The Tumor Microenvironment ISBN: 1493937995 ISBN-13(EAN): 9781493937998 Издательство: Springer Рейтинг: Цена: 130430.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book covers core and emerging in vitro and in vivo protocols used to study how various components of the tumor microenvironment are established and subsequently interact with tumor cells to facilitate carcinogenesis. In addition, the book examines research topics including cellular and molecular biology approaches, in vivo genetic approaches, various “omics”-based strategies, therapeutic strategies to target the microenvironment, and, finally, advanced techniques in the fields of tissue engineering and nanotechnology. Written and validated in the laboratories of a number of trusted collaborating authors for the highly successful Methods in Molecular Biology series, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Practical and authoritative, The Tumor Microenvironment: Methods and Protocols constitutes a compendium of techniques now available to a broad audience, including basic and clinician scientists, systems biologists, and biological engineers.
Автор: Kalinski Название: Tumor Immune Microenvironment in Cancer Progression and Cancer Therapy ISBN: 3319675753 ISBN-13(EAN): 9783319675756 Издательство: Springer Рейтинг: Цена: 167700.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The tumor microenvironment has become a very important and hot topic in cancer research within the past few years. The tumor microenvironment is defined as the normal cells, molecules, and blood vessels that surround and feed a tumor cell. As many scientists have realized, studying the tumor microenvironment has become critical to moving the field forward, since there are many players in a tumor’s localized and surrounding area, which can significantly change cancer cell behavior. There is a dual relationship wherein the tumor can change its microenvironment and the microenvironment can affect how a tumor grows and spreads. Tumor Microenvironment in Cancer Progression and Cancer Therapy aims to shed light on the mechanisms, factors, and mediators that are involved in the cancer cell environment. Recent studies have demonstrated that in addition to promoting tumor progression and protecting tumor cells from the spontaneous immune-mediated rejection and different forms of cancer therapeutics, tumor microenvironment can also be a target and mediator of both standard and newly-emerging forms of cancer therapeutics. Thus, the dual role of the tumor microenvironment is the integral focus of the volume. The volume highlights the bi-directional interactions between tumor cells and non-malignant tumor component during tumor progression and treatment. It also focuses on the three groups of the reactive tumor component: stromal cells, blood vessels and the infiltrating immune cells. These three groups are discussed under the lens of their role in promoting tumor growth, shielding the tumor from rejection and from standard forms of cancer therapies. They are emerging as targets and mediators of standard and new forms of potential therapy.
Автор: Aref Название: Ex Vivo Engineering of the Tumor Microenvironment ISBN: 3319453955 ISBN-13(EAN): 9783319453958 Издательство: Springer Рейтинг: Цена: 149060.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This volume will outline how to recreate the tumor microenvironment, to culture primary tumors without the need for developmental priming factors, and to deliver targeted therapeutics in a manner that recapitulates pharmacokinetics in vivo. Much of what may be learned from this volume will aid in understanding many aspects of the enhanced study of tumor cell biology in a physiologic context, open new avenues for drug screening and biomarker development, and accelerate the preclinical evaluation of novel personalized medicine strategies for patients in real time.
Автор: Andrei Thomas-Tikhonenko Название: Cancer Genome and Tumor Microenvironment ISBN: 1461425247 ISBN-13(EAN): 9781461425243 Издательство: Springer Рейтинг: Цена: 243800.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: There exists a large body of evidence suggesting that well-known mutations in cancer genes profoundly affect tumor milieu. The reviews in this book explore in detail how tumor microenvironment and progression are "hard-wired" at the genetic level.
Автор: Yefenof Название: Innate and Adaptive Immunity in the Tumor Microenvironment ISBN: 9048177138 ISBN-13(EAN): 9789048177134 Издательство: Springer Рейтинг: Цена: 158380.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Recent studies, however, indicate that the tumor microenvironment is unique in providing both supportive and inhibitory factors that determine the fate of the tumor and its host.
Автор: Constantinos Koumenis; Ester Hammond; Amato Giacci Название: Tumor Microenvironment and Cellular Stress ISBN: 1461459141 ISBN-13(EAN): 9781461459149 Издательство: Springer Рейтинг: Цена: 191560.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Constitutes proceeding that discusses different cellular and animal models of TME study and identifies common pathways that are candidates for therapeutic intervention, stimulate collaboration between groups that are focused on elucidation of biochemical aspects of stress biology and groups that study pathophysiological aspects of stress pathways.
Автор: Rejniak Название: Systems Biology of Tumor Microenvironment ISBN: 3319420216 ISBN-13(EAN): 9783319420219 Издательство: Springer Рейтинг: Цена: 148020.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This edited volume discusses the complexity of tumor microenvironments during cancer development, progression and treatment. Each chapter presents a different mathematical model designed to investigate the interactions between tumor cells and the surrounding stroma and stromal cells. The topics covered in this book include the quantitative image analysis of a tumor microenvironment, the microenvironmental barriers in oxygen and drug delivery to tumors, the development of tumor microenvironmental niches and sanctuaries, intravenous transport of the circulating tumor cells, the role of the tumor microenvironment in chemotherapeutic interventions, the interactions between tumor cells, the extracellular matrix, the interstitial fluid, and the immune and stromal cells. Mathematical models discussed here embrace both continuous and agent-based approaches, as well as mathematical frameworks of solid mechanics, fluid dynamics and optimal control theory. The topics in each chapter will be of interest to a biological community wishing to apply the mathematical methods to interpret their experimental data, and to a biomathematical audience interested in exploring how mathematical models can be used to address complex questions in cancer biology.
Автор: Domenico Ribatti Название: The Role of Microenvironment in the Control of Tumor Angiogenesis ISBN: 3319278185 ISBN-13(EAN): 9783319278186 Издательство: Springer Рейтинг: Цена: 121890.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
Prelims
1. Tumor microenvironment
1.1. Metastatic cascade
1.2. Epithelial-mesenchymal transition
1.3. The extracellular matrix
2. Tumor blood vessels and tumor endothelial cells
2.1. Tumor basement membrane
2.2. Tumor pericytes
3. Tumor angiogenesis
3.1. Sprouting angiogenesis
3.2. Vascular co-option
3.3. Vasculogenic mimicry
3.4. Intussusceptive microvascular growth
4. Inflammatory cells in tumor microenvironment
4.1. Neutrophils
4.2. Eosinophils and dendritic cells
4.3. Lymphocytes and platelets
4.4. Mast cells
4.5. Macrophages
4.6. Tie-2 expressing monocytes (TEMs)
4.7. Fibroblasts
4.8. Osteoblasts and osteoclasts
4.9. Cancer stem cells (CSCs)
4.10.Circulating endothelial cells and endothelial precursor cells
5. Therapeutic strategies, the concept of "normalization" and the role of VEGF inhibition
Index
Автор: Lekin Sandra Название: Breast Cancer: Tumor Microenvironment and Biology ISBN: 1632410680 ISBN-13(EAN): 9781632410689 Издательство: Неизвестно Цена: 134050.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The causes of cancer are diversified. Cancer is the principal reason of death in the majority of countries and it results in enormous financial, societal and mental burden. Breast cancer is the most diagnosed kind of cancer and the foremost reason of deat
Автор: Rebecca G. Bagley Название: The Tumor Microenvironment ISBN: 146142660X ISBN-13(EAN): 9781461426608 Издательство: Springer Рейтинг: Цена: 243800.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book explores the many biological and physical aspects of the tumor microenvironment. It represents a superb compilation of the latest thoughts and data on this topic, and the in-depth chapters are written by known professionals in the field.
Автор: Koumenis Название: Tumor Microenvironment ISBN: 3319266640 ISBN-13(EAN): 9783319266640 Издательство: Springer Рейтинг: Цена: 174150.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This volume covers the topics presented at the 3rd International Conference on Tumor Microenvironment and Cellular Stress by an international community of researchers. The conference brings together scientists to discuss different cellular and animal models of tumor microenvironment study and identify common pathways that are candidates for therapeutic intervention; stimulate collaboration between groups that are more focused on elucidation of biochemical aspects of stress biology (e.g., HIF regulation) and groups that study the pathophysiological aspects of stress pathways or engaged in drug discovery; and critically evaluate novel targets for imaging or therapeutic intervention that would be of use to the tumor microenvironment community and pharmaceutical industry.
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