This unique advanced textbook provides a clear and comprehensive overview of gene delivery, gene therapy and genetic pharmacology, with descriptions of the main gene transfer vectors and a set of selected therapeutic applications, along with safety considerations. The second edition features new groundbreaking material on genome editing using the recently discovered CRISPR/Cas9 system and on cancer immunotherapy by CAR-T cells. It also presents the historical milestone of gene therapy application in the field of severe combined immunodeficiency, and other fields of gene therapy and molecular medicine.
The use of gene transfer is exponentially growing in the scientific and medical communities for day-to-day cell biology experiments and swift development of gene therapy, which is already revolutionizing medicine. In this advanced textbook, more than 30 leading scientists come together to explore these topics.
This educational introduction provides the background material needed to further explore the subject as well as relevant research literature. It is an invaluable resource to Master, PhD or MD students, post-doctoral scientists or medical doctors, as well as any scientist wishing to deliver a gene or synthetic nucleotide or develop a gene therapy strategy. The second edition's simple and synthetic content will be of value to any reader interested in the biological and medical revolution derived from the elucidation of the human genome.
Автор: N.D. Chasteen Название: Vanadium in Biological Systems ISBN: 9401074070 ISBN-13(EAN): 9789401074070 Издательство: Springer Рейтинг: Цена: 186340.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Over the past several decades, vanadium has increasingly attracted the interest of biologists and chemists. The discovery by Cantley in 1977 that vanadate is a potent inhibitor of ATPases lead to numerous studies of the inhibitory and stimulatory effects of vanadium on phosphate metabolizing enzymes.
Автор: Federico Cappuzzo Название: Guide to Targeted Therapies: EGFR mutations in NSCLC ISBN: 3319030582 ISBN-13(EAN): 9783319030586 Издательство: Springer Рейтинг: Цена: 37260.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This concise, practical handbook discusses EGFR mutations in NSCLC, testing methods and technology, current and emerging therapies, and resources. It offers readers a fast synopsis of key studies and available treatment options.
Автор: Maria A. Livrea Название: Vitamin A and Retinoids: An Update of Biological Aspects and Clinical Applications ISBN: 3034895747 ISBN-13(EAN): 9783034895743 Издательство: Springer Рейтинг: Цена: 46570.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book advances the knowledge of mechanisms regulating metabolism and functioning of vitamin A and offers the most recent results of research on the clinical efficiency of retinoids in skin disorders and cancer.
Автор: Patrick M. Dansette; Robert R. Snyder; Terrence J. Название: Biological Reactive Intermediates Vi ISBN: 1461351855 ISBN-13(EAN): 9781461351856 Издательство: Springer Рейтинг: Цена: 186330.00 T Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Peter H. Redfern; B. Lemmer Название: Physiology and Pharmacology of Biological Rhythms ISBN: 3642082653 ISBN-13(EAN): 9783642082658 Издательство: Springer Рейтинг: Цена: 478890.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: With contributions by numerous experts
Автор: Henri Begleiter Название: Biological Effects of Alcohol ISBN: 1468436341 ISBN-13(EAN): 9781468436341 Издательство: Springer Рейтинг: Цена: 93160.00 T Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Bernard Testa Название: Pharmacokinetic Optimization in Drug Research: Biological, Physicochemical, and Computational Strategies ISBN: 3906390225 ISBN-13(EAN): 9783906390222 Издательство: Wiley Рейтинг: Цена: 153120.00 T Наличие на складе: Невозможна поставка. Описание: In this age of combinatorial chemistry and high-throughput technologies, bioactive compounds called hits are discovered by the thousands. However, the road that leads from hits to lead compounds and then to pharmacokinetically optimized clinical and drug candidates is very long indeed. As a result, the screening, design, and optimization of pharmacokinetic properties has become the bottleneck and a major challenge in drug research. To shorten the time-consuming develop-ment and high rate of attrition of active compounds ultimately doomed by hidden pharmacokinetic defects, drug researchers are coming to incorporate structure-permeation, structure-distribution, structure-metabolism, and structure-toxicity relations into drug-design strategies. To this end, powerful biological, physicochemical, and computational approaches are being developed whose objectives are to increase the clinical relevance of drug design, and to eliminate as soon as possible compounds with unfavorable physicochemical properties and pharmacokinetic profiles. Toxicological issues are also of utmost importance in this paradigm. There was, hence, an urgent need for a book covering this field in an authoritative, didactic, comprehensive, factual, and conceptual manner. In this work of unique breadth and depth, international authorities and practicing experts from academia and industry present the most modern biological, physicochemical, and computational strategies to optimize gastrointestinal absorption, protein binding and distribution, brain permeation, and metabolic profile. The biological strategies emphasized in the book include cell cultures and high-throughput screens. The physicochemical strategies focus on the determination and interpretation of solubility, lipophilicity, and related molecular properties as factors and predictors of pharmacokinetic bahavior. Particular attention is paid to the lipophilicity profiles of ionized compounds, to lipophicity measurements in anisotropic media (liposomes/water, IAM columns), and to permeability across artificial membranes. Computational strategies comprise virtual screening, molecular modelling, lipophilicity, and H-bonding fields and their importance for structure-disposition relations. This book is both about theoretical and technological breakthroughs. Thus, molecular properties are contemplated from a dual perspective, namely a) their interpretation in biological and/or physicochemical terms, and b) their value in screening, lead optimization, and drug-candidate selection. In addition to its 33 chapters, the book includes a CD-ROM containing the invited lectures, oral communications and posters (in full version) presented at the Second LogP Symposium, 'Lipophilicity in Drug Disposition -- Practical and Computational Approaches to Molecular Properties Related to Drug Permeation, Disposition and Metabolism', held at the University of Lausanne in March 2000.
Автор: Bernard Testa Название: Pharmacokinetic Profiling in Drug Research: Biological, Physicochemical, and Computational Strategies ISBN: 3906390357 ISBN-13(EAN): 9783906390352 Издательство: Wiley Рейтинг: Цена: 239660.00 T Наличие на складе: Поставка под заказ. Описание: Informatics and robotics are the workhorses of a technological revolution in drug research. On them are based combinatorial chemistry, which yields compounds by the many thousands, and high-throughput bioassays, which screen them for activity. The results are avalanches of `hits`, which invade the databases like swarms of locusts.
Автор: Mortimer B. Lipsett Название: Gas Chromatography of Steroids in Biological Fluids ISBN: 1468406930 ISBN-13(EAN): 9781468406931 Издательство: Springer Рейтинг: Цена: 46570.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: During the past decade we have witnessed a revolution in analytical methods. Thus, I hope that there will be adequate documentation of the reliability of the methods as well as a comparison of the advantages and disadvantages of this analytical method with other classical methods.
Автор: Margarett K. Davis; Lars A. Hanson; Charles E. Isa Название: Integrating Population Outcomes, Biological Mechanisms and Research Methods in the Study of Human Milk and Lactation ISBN: 1461351324 ISBN-13(EAN): 9781461351320 Издательство: Springer Рейтинг: Цена: 139750.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Integrating Population Outcomes, Biological Mechanisms and Research Methods in the Study of Human Milk and Lactation is the product of the 10th Conference of the International Society for Research on Human Milk and Lactation, held on September 15-19, 2000, in Tucson, Arizona.
Автор: Elena Mikhailovna Egorova; Aslan Amirkhanovich Kub Название: Biological Effects of Metal Nanoparticles ISBN: 3319309056 ISBN-13(EAN): 9783319309057 Издательство: Springer Рейтинг: Цена: 125770.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: CONTENTSAbbreviations and designationsIntroduction Part IPREPARATION AND CHARACTERIZATION OF METAL NANOPARTICLES IN SOLUTIONS Chapter 1Methods of the nanoparticles preparation in solutions LI. Introductory remarks1.2. Principles used for the choice of methods1.3. Chemical synthesis with traditional reducing agents1.3.1.General considerations1.3.2.Synthesis in water solution1.3.3.Synthesis in the two-phase system and non-aqueous solutions1.3.4.Synthesis in reverse micelles1.4. Photo-and radiation-chemical synthesis1.5. Electrochemical synthesis1.6. Biological reduction in water solution1.7. Summary Chapter 2Biochemical synthesis of metal nanoparticles2.1. Prerequisites of the method2.1.1.General information on the properties of flavonoids2.1.2.AOT/isooctane reverse micelles2.2. Cieneral scheme of the synthesis2.3. Peculiarities of the experimental procedure2.3.1.Preparation of the flavonoid micellar solution2.3.2.Extinction coefficient determination for the flavonoids in micellar solution2.4. Examples of the nanoparticles synthesis2.4.1. Silver nanoparticles2.4.2. Gold nanoparticles2.4.3. Copper nanoparticles Chapter 3Development of the biochemical synthesis for practical applicationsDetermination of the extinction coefficient for Ag nanoparticles3.1.1. Extinction coefficient of the complex3.1.2. Extinction coefficient of the nanoparticles3.2. The effect of C Qr /C Ag relation on the formation rate and yield of silver nanoparticles3.3. Preparation of small nanoparticles with narrow size distributionChapter 4Preparation of metal nanoparticles in water solutions on the basis of biochemical synthesis4.1. Preparation of nanoparticles as water dispersions by their transfer from micellar solution4.2. Characteristics of silver and gold nanoparticles in water solution4.2.1.Silver nanoparticles4.2.2.Gold nanoparticles4.3. Synthesis of silver and copper nanoparticles in water solution with natural stabilizers4.3.1.Starch-stabilized Ag nanoparticles4.3.2.Cyclodextrin-stabilized Ag nanoparticles4.3.3.Starch-stabilized Cu nanoparticles4.3.4.Comparison with the data found in literature Chapter 5Materials modified with metal nanoparticles5.1. Creation of liquid-phase materials with metal nanoparticles5.2. Solid materials with Ag and Cu nanoparticles Part IIBIOLOGICAL EFFECTS OF METAL NANOPARTICLESGeneral information Chapter 6The effect of metal nanoparticles on biological objects (analysisof the literature)6.1. Metal nanoparticles effects observed on microorganisms6.1.1. Antimicrobial activities of Ag nanoparticles6.1.2. Antimicrobial activities of Cu, Au and metal oxides nanoparticles....6.2. On the mechanism of antimicrobial activities of metal nanoparticles6.3. Summary Chapter 7Antimicrobial activity of nanoparticles stabilized by synthetic surface active substance7.1. Ag and Cu nanoparticles in liquid medium7.1.1.Varnish-paint materials with biocidal properties7.1.2.Water solutions of Ag nanoparticles7.2. Solid materials and polymer films with Ag nanoparticles Chapter 8The effect of silver nanoparticles on some objects from the fungal and v
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