Biological Effects of Alcohol, Henri Begleiter

Автор: Lawrence Fishbein
Название: Biological Effects of Dietary Restriction
ISBN: 364263494X ISBN-13(EAN): 9783642634949
Издательство: Springer
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Цена: 139310.00 T
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Описание: How does dietary restriction affect the physiological and biochemical state of laboratory animals? After a first look at feeding regimens and diets of laboratory animals, the book elaborates on a variety of age-associated toxicological and pathological endpoints including tumor development.

Автор: Elena Mikhailovna Egorova; Aslan Amirkhanovich Kub
Название: Biological Effects of Metal Nanoparticles
ISBN: 3319309056 ISBN-13(EAN): 9783319309057
Издательство: Springer
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Цена: 125770.00 T
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Описание: CONTENTSAbbreviations and designationsIntroduction
Part IPREPARATION AND CHARACTERIZATION OF METAL NANOPARTICLES IN SOLUTIONS
Chapter 1Methods of the nanoparticles preparation in solutions LI. Introductory remarks1.2. Principles used for the choice of methods1.3. Chemical synthesis with traditional reducing agents1.3.1.General considerations1.3.2.Synthesis in water solution1.3.3.Synthesis in the two-phase system and non-aqueous solutions1.3.4.Synthesis in reverse micelles1.4. Photo-and radiation-chemical synthesis1.5. Electrochemical synthesis1.6. Biological reduction in water solution1.7. Summary
Chapter 2Biochemical synthesis of metal nanoparticles2.1. Prerequisites of the method2.1.1.General information on the properties of flavonoids2.1.2.AOT/isooctane reverse micelles2.2. Cieneral scheme of the synthesis2.3. Peculiarities of the experimental procedure2.3.1.Preparation of the flavonoid micellar solution2.3.2.Extinction coefficient determination for the flavonoids in micellar solution2.4. Examples of the nanoparticles synthesis2.4.1. Silver nanoparticles2.4.2. Gold nanoparticles2.4.3. Copper nanoparticles
Chapter 3Development of the biochemical synthesis for practical applicationsDetermination of the extinction coefficient for Ag nanoparticles3.1.1. Extinction coefficient of the complex3.1.2. Extinction coefficient of the nanoparticles3.2. The effect of C Qr /C Ag relation on the formation rate and yield of silver nanoparticles3.3. Preparation of small nanoparticles with narrow size distributionChapter 4Preparation of metal nanoparticles in water solutions on the basis of biochemical synthesis4.1. Preparation of nanoparticles as water dispersions by their transfer from micellar solution4.2. Characteristics of silver and gold nanoparticles in water solution4.2.1.Silver nanoparticles4.2.2.Gold nanoparticles4.3. Synthesis of silver and copper nanoparticles in water solution with natural stabilizers4.3.1.Starch-stabilized Ag nanoparticles4.3.2.Cyclodextrin-stabilized Ag nanoparticles4.3.3.Starch-stabilized Cu nanoparticles4.3.4.Comparison with the data found in literature
Chapter 5Materials modified with metal nanoparticles5.1. Creation of liquid-phase materials with metal nanoparticles5.2. Solid materials with Ag and Cu nanoparticles

Part IIBIOLOGICAL EFFECTS OF METAL NANOPARTICLESGeneral information
Chapter 6The effect of metal nanoparticles on biological objects (analysisof the literature)6.1. Metal nanoparticles effects observed on microorganisms6.1.1. Antimicrobial activities of Ag nanoparticles6.1.2. Antimicrobial activities of Cu, Au and metal oxides nanoparticles....6.2. On the mechanism of antimicrobial activities of metal nanoparticles6.3. Summary
Chapter 7Antimicrobial activity of nanoparticles stabilized by synthetic surface active substance7.1. Ag and Cu nanoparticles in liquid medium7.1.1.Varnish-paint materials with biocidal properties7.1.2.Water solutions of Ag nanoparticles7.2. Solid materials and polymer films with Ag nanoparticles
Chapter 8The effect of silver nanoparticles on some objects from the fungal and v

Автор: Takemi Otsuki; Yasuo Yoshioka; Andrij Holian
Название: Biological Effects of Fibrous and Particulate Substances
ISBN: 4431563091 ISBN-13(EAN): 9784431563099
Издательство: Springer
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Цена: 111790.00 T
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Описание: This volume examines our current understanding of the biological effects of fibrous and particulate substances, including discussions on nanoparticles.

Автор: Paul B.S. Clarke; Maryka Quik; Franz Adlkofer; Kla
Название: Effects of Nicotine on Biological Systems II
ISBN: 3034874472 ISBN-13(EAN): 9783034874472
Издательство: Springer
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Цена: 46570.00 T
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Автор: Bernard Testa
Название: Pharmacokinetic Profiling in Drug Research: Biological, Physicochemical, and Computational Strategies
ISBN: 3906390357 ISBN-13(EAN): 9783906390352
Издательство: Wiley
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Цена: 239660.00 T
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Описание: Informatics and robotics are the workhorses of a technological revolution in drug research. On them are based combinatorial chemistry, which yields compounds by the many thousands, and high-throughput bioassays, which screen them for activity. The results are avalanches of `hits`, which invade the databases like swarms of locusts.

Автор: Evens
Название: Drug and Biological Development
ISBN: 0387329781 ISBN-13(EAN): 9780387329789
Издательство: Springer
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Цена: 85670.00 T
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Описание: The book is a complete discussion of product development in the pharmaceutical and biotechnology industries from discovery, to product launch, and through life cycle management. Format is optimized for education and training of health care professionals, especially fellows in training (MD, PharmD, PhD), at universities. Format of the book is a set of figures, tables and lists, that can become power-point style slides as well, and the detailed narrative descriptions, including real-life examples, illustrations, controversies in industry, and references. Industry and research experts (multidisciplinary – MD, PharmD, and PhD) are editors and authors. An added CD-ROM (slides only) enhances utility and marketability of book to course directors, providing the highly sought after slides for lectures.

Автор: Bernard Testa
Название: Pharmacokinetic Optimization in Drug Research: Biological, Physicochemical, and Computational Strategies
ISBN: 3906390225 ISBN-13(EAN): 9783906390222
Издательство: Wiley
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Цена: 153120.00 T
Наличие на складе: Невозможна поставка.
Описание: In this age of combinatorial chemistry and high-throughput technologies, bioactive compounds called hits are discovered by the thousands. However, the road that leads from hits to lead compounds and then to pharmacokinetically optimized clinical and drug candidates is very long indeed. As a result, the screening, design, and optimization of pharmacokinetic properties has become the bottleneck and a major challenge in drug research. To shorten the time-consuming develop-ment and high rate of attrition of active compounds ultimately doomed by hidden pharmacokinetic defects, drug researchers are coming to incorporate structure-permeation, structure-distribution, structure-metabolism, and structure-toxicity relations into drug-design strategies. To this end, powerful biological, physicochemical, and computational approaches are being developed whose objectives are to increase the clinical relevance of drug design, and to eliminate as soon as possible compounds with unfavorable physicochemical properties and pharmacokinetic profiles. Toxicological issues are also of utmost importance in this paradigm. There was, hence, an urgent need for a book covering this field in an authoritative, didactic, comprehensive, factual, and conceptual manner. In this work of unique breadth and depth, international authorities and practicing experts from academia and industry present the most modern biological, physicochemical, and computational strategies to optimize gastrointestinal absorption, protein binding and distribution, brain permeation, and metabolic profile. The biological strategies emphasized in the book include cell cultures and high-throughput screens. The physicochemical strategies focus on the determination and interpretation of solubility, lipophilicity, and related molecular properties as factors and predictors of pharmacokinetic bahavior. Particular attention is paid to the lipophilicity profiles of ionized compounds, to lipophicity measurements in anisotropic media (liposomes/water, IAM columns), and to permeability across artificial membranes. Computational strategies comprise virtual screening, molecular modelling, lipophilicity, and H-bonding fields and their importance for structure-disposition relations. This book is both about theoretical and technological breakthroughs. Thus, molecular properties are contemplated from a dual perspective, namely a) their interpretation in biological and/or physicochemical terms, and b) their value in screening, lead optimization, and drug-candidate selection. In addition to its 33 chapters, the book includes a CD-ROM containing the invited lectures, oral communications and posters (in full version) presented at the Second LogP Symposium, 'Lipophilicity in Drug Disposition -- Practical and Computational Approaches to Molecular Properties Related to Drug Permeation, Disposition and Metabolism', held at the University of Lausanne in March 2000.

Автор: Y.H. Caplan; Amanda J. Jenkins
Название: Drug Testing in Alternate Biological Specimens
ISBN: 1617377325 ISBN-13(EAN): 9781617377327
Издательство: Springer
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Цена: 186340.00 T
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Описание: Although the specimen of choice in the US drug testing industry is urine, and serum in clinical medicine, interest has recently grown in the use of other matrices as drug testing media. This book provides researchers and forensic toxicologists with a convenient general text summarizing the state of knowledge today.

Название: Tryptophan metabolism: implications for biological processes, health and disease
ISBN: 3319156292 ISBN-13(EAN): 9783319156293
Издательство: Springer
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Цена: 149060.00 T
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Описание: This book discusses the relationship between cellular immunity and tryptophan metabolism, as well as its products, serotonin and melatonin, in the development of several diseases and reappraises the common signal transduction pathways of the neurodegenerative diseases, carcinogenesis, immune tolerance, inflammation, hypersensitivity reactions, neuropsychiatric disorders, in addition to bacterial tryptophan biosynthesis and novel antimicrobials. Tryptophan Metabolism: Implications for Biological Processes, Health and Disease presents fundamental information on tryptophan related metabolic pathways and metabolites, implications of these products for specific biological processes, diseases and conditions. This book focuses on effects of tryptophan metabolites on human health and will appeal to researchers, clinicians and students within this field.