Translational Research in Muscular Dystrophy, Shin`ichi Takeda; Yuko Miyagoe-Suzuki; Madoka Mori

Автор: Peplow
Название: Acute Brain Impairment: Scientific Discoveries and Translational Research
ISBN: 1782629505 ISBN-13(EAN): 9781782629504
Издательство: Royal Society of Chemistry
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Цена: 209790.00 T
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Описание: A book useful to postgraduate students and researchers in medicinal chemistry and pharmacology, as well as specialists in the acute brain injury field.

Автор: Camilla Bernardini
Название: Duchenne Muscular Dystrophy
ISBN: 1493973738 ISBN-13(EAN): 9781493973736
Издательство: Springer
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Цена: 139750.00 T
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Описание: This volume explores experimental approaches used to study Duchenne muscular dystrophy (DMD), an X-linked degenerative skeletal muscle disease caused by mutations in the dystrophin gene. Including the latest progress and scientific achievements, the book covers recent discoveries achieved through in vivo gene editing which have proven to be promising in restoring dystrophin expression, at least in ameliorating skeletal muscle symptoms, and the contents focus on “Omics” techniques in gene expression, protein expression, miRNAs, and long non-coding RNA analysis, as well as experimental studies of the structural/functional changes affecting the skeletal and cardiac muscles and ongoing preclinical studies and clinical trials. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. 

Автор: Emery Alan
Название: Duchenne Muscular Dystrophy
ISBN: 0199681481 ISBN-13(EAN): 9780199681488
Издательство: Oxford Academ
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Цена: 110880.00 T
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Описание: Fully revised and updated the new edition of Duchenne Muscular Dystrophy discusses the recent advances in the field of molecular biology for prenatal diagnosis and genetic counselling to the recent pioneering work with anti-sense oligonucleotides, and the possibility of effective RNA therapy.

Автор: Katherine M.D. Bushby; Louise V.B. Anderson
Название: Muscular Dystrophy
ISBN: 1617371408 ISBN-13(EAN): 9781617371400
Издательство: Springer
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Цена: 135090.00 T
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Описание: Some common themes can be recognized, however, including the involvement of five members of the dystrophin-associated complex (dystrophin and four sarcoglycans) in different types of MD, and the involvement of two nuclear envelope proteins in producing an Emery-Dreifuss MD phenotype.

Название: Muscular Dystrophy and Other Neuromuscular Diseases
ISBN: 1138976571 ISBN-13(EAN): 9781138976573
Издательство: Taylor&Francis
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Цена: 35720.00 T
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Описание: Here is a thoughtful new book for professionals who assist persons afflicted with neuromuscular disorders to help them and their families adapt to lifestyle changes accompanying the onset of these disorders. Health care professionals provide strategies to maintain the psychosocial well-being of children and adults with neuromuscular disorders which, in addition to physical damage, also assault the sense of self and challenge the individual’s ability to move and communicate. Chapters describe the psychosocial aspects of a variety of neuromuscular diseases such as Duchenne and myotonic muscular dystrophy, multiple sclerosis, amyotrophic lateral sclerosis, Friedeich’s ataxia, and Charcot-Marie-Tooth disease. The distinctive characteristics of each disease are examined with special attention given to the natural history, treatment, management, and psychosocial issues of the specific disorder. Beyond the clinical and research importance of Muscular Dystrophy and Other Neuromuscular Diseases, it also addresses the anxiety, doubts, and questions felt by patients with chronic progressive disabilities and their families. This helpful guide is unique in the way it features the interaction of professionals in the social services, psychology, religion, and various medical specialties in the care and treatment of these patients. Professionals in all of these disciplines, as well as the patients and families afflicted by these disorders, will benefit from this valuable resource.

Автор: Corrado Angelini
Название: Muscular Dystrophy: Causes & Management
ISBN: 1626184607 ISBN-13(EAN): 9781626184602
Издательство: Nova Science
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Цена: 304120.00 T
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Описание: Muscular Dystrophies include a heterogeneous series of diseases that range from childhood to adult onset cases, of difficult diagnosis and treatment. This book presents the state of the art in muscular dystrophies, after the molecular revolution. In the field of patients diagnosis, several advances have been done by recognising new entities. New techniques such as biochemical, molecular advancements, and the use of muscle MRI are collected that allow rapid diagnosis. Also, advances in therapy and therapeutical trials are presented in Duchenne and other muscular dystrophies and some novel treatments in glycogen storage disease by enzyme replacement are proposed. Both rehabilitation techniques and other treatments deserve particular attention for the improvements observed.

Автор: R. Heene
Название: Experimental Myopathies and Muscular Dystrophy
ISBN: 3642662021 ISBN-13(EAN): 9783642662027
Издательство: Springer
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Цена: 121110.00 T
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Описание: Experimental Myopathies and Muscular Dystrophy. A Study of the Formal Pathogenesis of Primary Myopathies as Exemplified in the Myopathy of 2,4-Dichlorophenoxyacetic Acid The histochemical types of muscle fibres are described and a report presented of the histological and histochemical altera- tions in skeletal muscles (tibialis anterior, gastrocnemius and soleus muscles) of rats given intraperitoneal injections of the herbicide, 2,4-dichlorophenoxyacetic acid (2,4-0). The liver and myocardium of the experimental animals were also examined. In skeletal muscle, alterations occurring acutely within 1 to 1. 5 h after injection of a single dose of 300 mg/kg 2,4-0 could be distinguished from changes which developed subacutely in the course of treatment with repeated injections of one quarter to one half of the LDSO of the substance. In both con- ditions white (type 2B/Am) muscle fibres were involved pre- dilectively. The principal histochemical effect of acute intoxi- cation observed was leakage of phosphorylase and glycogen from white muscle fibres, whereas some of the red fibres (type 2A/C ) m showed an increase in primary glycogen and phosphorylase activ- ity. These changes, which must be considered nonspecifi, were established by use of a gelatin incubation technique. They occurred as typical findings in the middle and deep areas of the anterior tibial muscle. In other muscles or different layers of the same muscle, these changes varied considerably in degree. Thus the gastrocnemius and soleus muscles displayed only minor or no alterations.

Автор: Camilla Bernardini
Название: Duchenne Muscular Dystrophy
ISBN: 1493984667 ISBN-13(EAN): 9781493984664
Издательство: Springer
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Цена: 102480.00 T
Наличие на складе: Поставка под заказ.
Описание: This volume explores experimental approaches used to study Duchenne muscular dystrophy (DMD), an X-linked degenerative skeletal muscle disease caused by mutations in the dystrophin gene. Including the latest progress and scientific achievements, the book covers recent discoveries achieved through in vivo gene editing which have proven to be promising in restoring dystrophin expression, at least in ameliorating skeletal muscle symptoms, and the contents focus on “Omics” techniques in gene expression, protein expression, miRNAs, and long non-coding RNA analysis, as well as experimental studies of the structural/functional changes affecting the skeletal and cardiac muscles and ongoing preclinical studies and clinical trials. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. 

Автор: Lyons-Weiler James
Название: Cures Vs. Profits: Successes In Translational Research
ISBN: 9814730149 ISBN-13(EAN): 9789814730143
Издательство: World Scientific Publishing
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Цена: 15840.00 T
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Описание: Did You Ever Wonder Whether Doctors Want Cures, Or Just Treatments?Did You Know ...•Grapefruit Can Interact With Over 100 Drugs, But It May Be Useful For Reducing Blood Pressure And For Weight Loss?•Adhd Over Diagnosis Is Now Recognized Widely As A Fact, And There Are Existing — And New Ways — To Avoid A Misdiagnosis?•Studies Have Been Conducted Demonstrating The Utility Of Omega 3 Fatty Acids, Meditation, Yoga, And Melatonin For Some Important Symptoms Of Adhd, Including Executive Functions?•Vaccines Have Saved Millions Of Lives In The Last Decade?•Breast Cancer Rates Are Declining In The Us, But Have Been Steadily Increasing In Japan?•Doctors Are Getting Better At Predicting Which Chemotherapy Will, And Will Not Work, On Certain Cancers?•There Are Vaccines Against Cancer?This Book Reviews Recent Key, Hard-Won Successes And Findings From Recent Biomedical Research. Written By One Of The Most Ardent Defenders Of The Public Trust In Science, It Provides An Accessible, Detailed Look At Successes In Translational Biomedical And Clinical Research. The Author Provides An Optimistic, Forward-Looking View For The Possibility Of Change For The Public Good, Cutting Through The Controversy And Gets To Very Core Of Each Topic. The Public Can Be Optimistic About The Future Of Medicine, But Only If They Learn The Facts Of These Advances, And Learn What Their Doctors Should Be Expected To Know.Highly Referenced, And Filled With Interviews From Experts And People Directly Involved In The Research Behind The New Facts In Each Chapter, This Book Is A Rich Source Of Information On Advances In Biomedicine That You Will Want To Share With Your Family & Friends.

Автор: William C.S. Cho
Название: MicroRNAs in Cancer Translational Research
ISBN: 9400789971 ISBN-13(EAN): 9789400789975
Издательство: Springer
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Цена: 174130.00 T
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Описание: This timely publication includes chapters by world-renowned experts and focuses on our current understanding of miRNAs. It assesses their potential applications in cancer diagnosis, prognosis and therapeutic targets, and identifies areas for further research.

Автор: Perumana R. Sudhakaran; Oommen V. Oommen; M. Radha
Название: Perspectives in Cancer Prevention-Translational Cancer Research
ISBN: 8132234812 ISBN-13(EAN): 9788132234814
Издательство: Springer
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Цена: 156720.00 T
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Описание: Being a complex disease that affects millions of people world over, cancer research has assumed great significance. The IVth International Symposium on Translational Cancer Research held in Udaipur, India in December 2011, discussed various aspects of the biological processes in cancer cells and approaches to cancer prevention.

Автор: Shashi Bala Singh; Nanduri R. Prabhakar; Srinivas
Название: Translational Research in Environmental and Occupational Stress
ISBN: 8132219279 ISBN-13(EAN): 9788132219279
Издательство: Springer
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Цена: 149060.00 T
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Описание: Cutting edge technologies can propel a simple finding in basic science to a concept that can be of immense value to the society. While applying novel techniques to unravel the mysteries of biological processes, an offshoot of applied branch emerged. This field, which is now widely referred to as Translational Research utilizes basic science findings and translates these findings into innovative concepts for the benefit of mankind. This branch of science has evolved into a multidisciplinary juggernaut encompassing all known fields of science as varied as biomedicine, environment, law, economics, sociology, etc. With the ever increasing interest in this branch and the dreams and aspirations that this field can bring, basic science researchers are now taking a bold step into this new realm, merging different fields of knowledge to come up with novel inventions. This book "Translational research in environmental and occupational stress" provides and insight into the research that led to discoveries, inventions and development of novel technologies which will have a tremendous impact on the future of mankind.