Автор: Jack A. Rall Название: Mechanism of Muscular Contraction ISBN: 1493943367 ISBN-13(EAN): 9781493943364 Издательство: Springer Рейтинг: Цена: 121110.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Fundamental discoveries in the 1950s relating to the mechanism of muscle contraction fueled an explosion of knowledge in the latter half of the 20th century. This book traces in depth the evolution of ideas from the 1950s into the 21st century. In a scholarly yet highly readable monograph, the book describes the history on which our current understanding of muscle function is based. This is the most comprehensive study and first book-length treatment of the muscle field in over forty years. In order to provide perspective into the thinking about an issue at the time of its discovery, often the investigators describe in their own words an important result or conclusion as it appeared in an original paper. Numerous figures from the original papers are included in order to allow the reader to see the data that led to important conclusions. More than a history of experimental facts, the book describes backgrounds of many of the key investigators to allow a deeper insight into their motivations and approach to science. Controversies in the muscle field are discussed along with some missed opportunities and false trails. An amazing variety of experimental techniques have been brought to bear on the investigation of the mechanism of muscular contraction. Background of these various techniques is presented in order to gain a fuller appreciation of their strengths and weaknesses. The book is organized into nine chapters with over 170 illustrations and 1,200 references. The book provides insight into scientific thought and forms a framework for future enquiry into muscle function. The author, an emeritus professor in the department of physiology and cell biology at Ohio State University, has been a contributor to research in the muscle field for over forty years.--
Автор: Emery Alan Название: Duchenne Muscular Dystrophy ISBN: 0199681481 ISBN-13(EAN): 9780199681488 Издательство: Oxford Academ Рейтинг: Цена: 110880.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Fully revised and updated the new edition of Duchenne Muscular Dystrophy discusses the recent advances in the field of molecular biology for prenatal diagnosis and genetic counselling to the recent pioneering work with anti-sense oligonucleotides, and the possibility of effective RNA therapy.
Автор: Sumner, Charlotte J Название: Spinal Muscular Atrophy ISBN: 0128036850 ISBN-13(EAN): 9780128036853 Издательство: Elsevier Science Рейтинг: Цена: 132500.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
Spinal Muscular Atrophy: Disease Mechanisms and Therapy provides the latest information on a condition that is characterized by motoneuron loss and muscle atrophy, and is the leading genetic cause of infant mortality. Since the identification of the gene responsible for SMA in 1995, there have been important advances in the basic understanding of disease mechanisms, and in therapeutic development.
This book provides a comprehensive accounting of recent advances in basic and clinical research that covers SMA clinical features and standards of care, multifaceted aspects of SMN protein functions and SMA disease pathology, various animal models, and biomarkers, as well as current therapeutic development.
This title is ideal for graduate students/postdocs and principal investigators who are already in the SMA field and need to keep updated on recent findings and approaches, and for those who are new to, or would like to join, the field. Likewise, users will find an excellent source of reading for biotech/pharma scientists, clinical researchers, and practitioners, regulators, and patients and their advocacy organizations. Furthermore, this book is a handy reference for researchers and clinicians who may want to apply the research strategies and therapeutic approaches in SMA to other rare diseases.
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