Thyroid Hormone Nuclear Receptor, Michelina Plateroti; Jacques Samarut

Автор: Plateroti
Название: Thyroid Hormone Nuclear Receptor
ISBN: 1493979019 ISBN-13(EAN): 9781493979011
Издательство: Springer
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Цена: 102480.00 T
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Описание: This volume aims to detail the advances in the field of Thyroid hormones (THs), namely T3 and T4, and their nuclear receptor TRs from a conceptual and methodological point of view. Chapters guide readers through a general introduction, TR's engineered mice, human genetics of TRs, control of the hypothalamus-pituitary-thyroid (HPT) axis, the relevance of the local THs production and metabolism and pathological consequences of TH/TR alterations. Non-mammalian models are also presented and discussed. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Thyroid Hormone Nuclear Receptor: Methods and Protocols aims to ensure successful results in the further study of this vital field.

Автор: Hinrich Gronemeyer; Ulrike Fuhrmann; Karsten Parcz
Название: Molecular Basis of Sex Hormone Receptor Function
ISBN: 3662036916 ISBN-13(EAN): 9783662036914
Издательство: Springer
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Цена: 46570.00 T
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Описание: How sex hormone receptors and all the other members of the nuclear receptor superfamily do such a remarkable job has fascinated scientists for decades.

Автор: Bernd Nilius; Veit Flockerzi
Название: Mammalian Transient Receptor Potential (TRP) Cation Channels
ISBN: 3662512238 ISBN-13(EAN): 9783662512234
Издательство: Springer
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Цена: 330870.00 T
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Описание: This book offers up-to-date information on the molecular and functional properties and pharmacology of mammalian Transient Receptor Potential channels, from close-up views of single protein/channels to broader principles of function and important pathologies.

Автор: Xiaoting Zhang
Название: Estrogen Receptor and Breast Cancer
ISBN: 3319993496 ISBN-13(EAN): 9783319993492
Издательство: Springer
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Цена: 158380.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The discovery of ER by Dr. Elwood Jensen exactly 60 years ago has not only led to the birth of a whole new vital nuclear receptor research field but also made a rapid, direct and lasting impact on the treatment and prevention of breast cancer. Since that landmark discovery, tremendous progress has been made in our understanding of the molecular functions of ER and development of targeted therapies against ER pathways for breast cancer treatment. However, there is currently no book available addressing these discoveries and recent advancement in a historical and systematic fashion. This book is intended to provide comprehensive, most up-to-date information on the history and recent advancement of ER and breast cancer by world renowned leaders in the field. These chapters include the history of the discovery of ER; physiological and pathological roles of ER; recent discovery of ER cistrome, transcriptome and its regulation of noncoding RNAs such as microRNAs and enhancer RNAs in breast cancer; development and clinical practices of the first targeted therapy Tamoxifen and other antiestrogens for breast cancer treatment; structural basis of ER and antiestrogen actions; molecular insights into endocrine resistance; the role of ER mutants, ER-beta and environmental estrogens in breast cancer; and emerging state-of-the-art therapeutic approaches currently in development to overcome treatment resistance and future perspectives. The book will provide undergraduate and graduate students, basic scientists and clinical cancer researchers, residents, fellows, as well as clinicians, oncology educators and the general public a thorough and authoritative review of these exciting topics.

Автор: Alexander Sigalov
Название: Multichain Immune Recognition Receptor Signaling
ISBN: 1441918876 ISBN-13(EAN): 9781441918871
Издательство: Springer
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Цена: 213360.00 T
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Описание: This book shows how the structural similarity of MIRRs determines the general principles underlying MIRR-mediated transmembrane signaling mechanisms. In so doing, it provides the basis for existing and future therapeutic strategies targeting MIRRs.

Автор: T. Kenakin; J. A. Angus
Название: The Pharmacology of Functional, Biochemical, and Recombinant Receptor Systems
ISBN: 3642630286 ISBN-13(EAN): 9783642630286
Издательство: Springer
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Цена: 121890.00 T
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Описание: With contributions by numerous experts

Автор: Veit Flockerzi; Bernd Nilius
Название: Transient Receptor Potential (TRP) Channels
ISBN: 3642071147 ISBN-13(EAN): 9783642071140
Издательство: Springer
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Цена: 567410.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: With contributions by numerous experts

Автор: Xiaoting Zhang
Название: Estrogen Receptor and Breast Cancer
ISBN: 3030075931 ISBN-13(EAN): 9783030075934
Издательство: Springer
Рейтинг:
Цена: 158380.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The discovery of ER by Dr. Elwood Jensen exactly 60 years ago has not only led to the birth of a whole new vital nuclear receptor research field but also made a rapid, direct and lasting impact on the treatment and prevention of breast cancer. Since that landmark discovery, tremendous progress has been made in our understanding of the molecular functions of ER and development of targeted therapies against ER pathways for breast cancer treatment. However, there is currently no book available addressing these discoveries and recent advancement in a historical and systematic fashion. This book is intended to provide comprehensive, most up-to-date information on the history and recent advancement of ER and breast cancer by world renowned leaders in the field. These chapters include the history of the discovery of ER; physiological and pathological roles of ER; recent discovery of ER cistrome, transcriptome and its regulation of noncoding RNAs such as microRNAs and enhancer RNAs in breast cancer; development and clinical practices of the first targeted therapy Tamoxifen and other antiestrogens for breast cancer treatment; structural basis of ER and antiestrogen actions; molecular insights into endocrine resistance; the role of ER mutants, ER-beta and environmental estrogens in breast cancer; and emerging state-of-the-art therapeutic approaches currently in development to overcome treatment resistance and future perspectives. The book will provide undergraduate and graduate students, basic scientists and clinical cancer researchers, residents, fellows, as well as clinicians, oncology educators and the general public a thorough and authoritative review of these exciting topics.

Автор: Tomohiro Kurosaki; J?rgen Wienands
Название: B Cell Receptor Signaling
ISBN: 3319261312 ISBN-13(EAN): 9783319261317
Издательство: Springer
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Цена: 121890.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Altogether, the discoveriespresented provide a better understanding of B cell biology and help to explainsome B cell-mediated pathogenicities, like autoimmune phenomena or theformation of B cell tumors, while also paving the way for eventually combating thesediseases.

Автор: Majed M. Hamawy
Название: IgE Receptor (Fc?RI) Function in Mast Cells and Basophils
ISBN: 3662220245 ISBN-13(EAN): 9783662220245
Издательство: Springer
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Цена: 113190.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The high affinity IgE receptor (FceRI) plays a central role in allergic diseases including asthma, allergic rhinitis, atopic dermatitis, food and drug allergy. In addition, clinicians who are concerned with broadening their knowledge of the FceRI role in allergic diseases will find this book useful.

Автор: Yosef Yarden; Moshe Elkabets
Название: Resistance to Anti-Cancer Therapeutics Targeting Receptor Tyrosine Kinases and Downstream Pathways
ISBN: 3319679309 ISBN-13(EAN): 9783319679303
Издательство: Springer
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Цена: 149060.00 T
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Описание: This volume comprehensively covers the multiplicity and diversity of mechanisms underlying patient resistance to currently approved anti-cancer drugs, including tyrosine kinase inhibitors and monoclonal antibodies, blockers of growth factor receptors and their downstream pathways, which play essential functions in cancer progression.

Автор: Werner R. Loewenstein
Название: Principles of Receptor Physiology
ISBN: 3642650651 ISBN-13(EAN): 9783642650659
Издательство: Springer
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Цена: 121110.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Why should there be a handbook of sensory physiology, and if so, why now' The editors have asked this question, marshalled all of the arguments that seemed to speak against their project, and then discovered that most of these arguments really spoke in favor of it: there seemed to be no doubt that the attempt should be made and that it should be made now. No complete overview of sensory physiology has been attempted since Bethe's "Handbuch der normalen und pathologischen Physiologie", nearly forty years ago. Since then, the field has evolved with unforeseen rapidity. Although electric probing of single peripheral nerve fibers was begun by ADRIAN and ZOTTERMAN as early as 1926, in the somatosensory system, and extended to single optic nerve fibers by HARTLINE in 1932, the real upsurge of such single-unit studies has only come during the last two decades. Single-cell electrophysiology has now been applied to all sensory modalities and on almost every conceivable phylogenetic level. It has begun to clarify peripheral receptor action and is adding to our. understanding of the central processing of sensory information. In parallel with these developments, there have been fundamental studies of the physics and chemistry of the receptors themselves: these studies are leading to insights into the mechanisms of energy transduction and nerve impulse initiation.