Cancer Drug Resistance, Jose Rueff; Ant?nio Sebasti?o Rodrigues

Название: Multi-drug resistance in cancer
ISBN: 1607614154 ISBN-13(EAN): 9781607614159
Издательство: Springer
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Цена: 153720.00 T
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Описание: The efficacy of chemotherapeutic management of cancer is often severely limited. This book provides comprehensive reviews of multidrug resistance mechanisms. It includes up-to-date techniques for detection and imaging of drug transporters.

Автор: Goldie
Название: Drug Resistance in Cancer
ISBN: 0521482739 ISBN-13(EAN): 9780521482738
Издательство: Cambridge Academ
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Цена: 156290.00 T
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Описание: This book provides an accessible yet sophisticated account of the mechanisms responsible for drug resistance in cancer. In addition, the authors use clearly explained mathematical models to provide an insight into tumour development and the effectiveness and limitations of drug treatment.

Автор: Jun Zhou
Название: Multi-Drug Resistance in Cancer
ISBN: 1617796646 ISBN-13(EAN): 9781617796647
Издательство: Springer
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Цена: 153720.00 T
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Описание: The efficacy of chemotherapeutic management of cancer is often severely limited. This book provides comprehensive reviews of multidrug resistance mechanisms. It includes up-to-date techniques for detection and imaging of drug transporters.

Автор: Gunjan Arora; Andaleeb Sajid; Vipin Chandra Kalia
Название: Drug Resistance in Bacteria, Fungi, Malaria, and Cancer
ISBN: 3319486829 ISBN-13(EAN): 9783319486826
Издательство: Springer
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Цена: 186330.00 T
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Описание: This book is a compilation of past and recent knowledge in the field of emerging drug resistance. The book covers major aspects of drug resistance in bacteria, fungi, malaria, and cancer.Human survival on earth is constantly threatened by disease and syndrome.

Автор: I. George Fantus
Название: Insulin Resistance and Cancer
ISBN: 1461428181 ISBN-13(EAN): 9781461428183
Издательство: Springer
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Цена: 174130.00 T
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Описание: This book reviews the epidemiological associations between insulin resistance and cancer, offering in-depth detail of basic concepts of insulin and cancer and how they interact. This is followed by reviews of animal models which support this relationship.

Название: Resistance to photodynamic therapy in cancer
ISBN: 3319127292 ISBN-13(EAN): 9783319127293
Издательство: Springer
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Цена: 139750.00 T
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Описание: This volume provides a comprehensive review of resistance induced by photodynamic therapy (PDT) in tumor cells. Understanding the underlying mechanisms in this process leads to the improvement of therapeutic modality, in combination with chemotherapy, immunotherapy, and radiotherapy. Photodynamic therapy is a minimally invasive therapeutic procedure that can exert a selective or preferential cytotoxic activity toward malignant cells. The procedure involves administration of an intrinsically non-toxic photosensitizing agent (PS) followed by irradiation at a wavelength corresponding to a visible absorption band of the sensitizer. In the presence of oxygen, a series of events lead to direct tumor cell death, damage to the microvasculature, and induction of a local inflammatory reaction. Studies reveal that PDT can be curative, particularly in early stage tumors and this volume explores the potential of PDT, but also reveals strategic approaches to overcome resistance in tumor cells.

Автор: Jose Rueff; Ant?nio Sebasti?o Rodrigues
Название: Cancer Drug Resistance
ISBN: 1493933450 ISBN-13(EAN): 9781493933457
Издательство: Springer
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Цена: 139750.00 T
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Описание:

1. Cancer Drug Resistance: A Brief Overview from a Genetic Viewpoint
Josй Rueff and Antуnio S. Rodrigues

2. Classical and Targeted Anti-Cancer Drugs: An Appraisal of Mechanisms of Multidrug Resistance
Bruce C. Baguley

3. In Vitro Methods for Studying the Mechanisms of Resistance to DNA Damaging Therapeutic Drugs
Pasarat Khongkow, Anna

Автор: Mario Mandal?; Emanuela Romano
Название: Mechanisms of Drug Resistance in Cancer Therapy
ISBN: 3030105067 ISBN-13(EAN): 9783030105068
Издательство: Springer
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Цена: 139750.00 T
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Описание: A major objective of this book is to reveal unprecedented opportunities to understand and overcome drug resistance through the clinical assessment of rational therapeutic drug combinations and the use of predictive and prognostic biomarkers to enable patient stratification and tailor treatments. It offers to the readers an updated overview on the possible reasons of failure of new and promising therapeutic opportunities.

Автор: Alexey Larionov
Название: Resistance to Aromatase Inhibitors in Breast Cancer
ISBN: 3319179713 ISBN-13(EAN): 9783319179711
Издательство: Springer
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Цена: 130430.00 T
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Описание: Aromatase Inhibitors (AIs) treat postmenopausal estrogen receptor positive tumours, which constitute the majority of breast cancer patients. This comprehensive volume brings together the current knowledge from different relevant areas, including molecular mechanisms and translational aspects of drug resistance in AIs. Topics covered include research, experimental , and clinical data specifically focused on AI resistance in breast cancer. The volume will include three sections. The first section covers general knowledge about aromatase inhibitors, including regulation of aromatase genes, and structure and function of aromatase protein. The second section provides the detailed mechanisms of resistance to AIs, while the third section explores prediction of resistance and potential strategies to overcome resistance. Breast cancer is the most common female cancer and AIs significantly improve treatments outcomes compatibly to previously used endocrine treatments. However 10-15% of post-operative patients develop a relapse during adjuvant treatment with AIs; about 25-50% of the patients do not respond to AIs in neo-adjuvant or metastatic setting, and the majority of metastatic patients who initially respond develop resistance within 3 years. There is an important need to understand these mechanisms of resistance in order to develop methods of preventing or overcoming the resistance to AIs, which will ensure a more successful outcome in treating breast cancer.

Автор: Susan E. Bates; Kapil Mehta; Zahid H. Siddik
Название: Drug Resistance in Cancer Cells
ISBN: 1441927948 ISBN-13(EAN): 9781441927941
Издательство: Springer
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Цена: 139310.00 T
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Описание: The inability of cancer drugs to destroy metastatic tumors is the main reason cancer therapy fails. This comprehensive text offers current knowledge on genetic and epigenetic alterations that contribute to the development of drug resistance in cancer cells.

Автор: Ahmad Aamir
Название: Breast Cancer Metastasis and Drug Resistance: Challenges and Progress
ISBN: 303020300X ISBN-13(EAN): 9783030203009
Издательство: Springer
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Цена: 130430.00 T
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Описание: Resistance to therapies, both targeted and systemic, and metastases to distant organs are the underlying causes of breast cancer-associated mortality. The second edition of Breast Cancer Metastasis and Drug Resistance brings together some of the leading experts to comprehensively understand breast cancer: the factors that make it lethal, and current research and clinical progress. This volume covers the following core topics: basic understanding of breast cancer (statistics, epidemiology, racial disparity and heterogeneity), metastasis and drug resistance (bone metastasis, trastuzumab resistance, tamoxifen resistance and novel therapeutic targets, including non-coding RNAs, inflammatory cytokines, cancer stem cells, ubiquitin ligases, tumor microenvironment and signaling pathways such as TRAIL, JAK-STAT and mTOR) and recent developments in the field (epigenetic regulation, microRNAs-mediated regulation, novel therapies and the clinically relevant 3D models). Experts also discuss the advances in laboratory research along with their translational and clinical implications with an overarching goal to improve the diagnosis and prognosis, particularly that of breast cancer patients with advanced disease.

Автор: Thomas Efferth
Название: Resistance to Targeted ABC Transporters in Cancer
ISBN: 3319098004 ISBN-13(EAN): 9783319098005
Издательство: Springer
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Цена: 139750.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This critical review volume explores the theme of ABC transporters in the context of basic cancer research and its role in drug-resistant tumors. The chapters provided complement basic research by including investigations from translational applications to clinical oncology. The development of resistance is a major obstacle in cancer chemotherapy and the field has been moving rapidly in terms of determining the mechanisms for blocking ABC transporter-mediated drug efflux by specific inhibitors and thereby overcoming multidrug resistance. The volume covers these issues in careful detail. Additional topics include the relevance of ABC transporters in resistance to novel and established anticancer drugs and prognosis of patients to compounds, compounds used in photodynamic therapy, tyrosine kinase inhibitors and others. Furthermore, the potential of radiopharmaceuticals for diagnosis of multidrug-resistant tumors and of nanotechnology to combat drug-resistant tumors is also discussed.