Resistance to photodynamic therapy in cancer 9783319127293

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Название: Resistance to photodynamic therapy in cancer
ISBN: 9783319127293
Издательство: Springer
Классификация:

Онкология

Фармакология

Медицинская визуализация

ISBN-10: 3319127292
Обложка/Формат: Hardcover
Страницы: 263
Вес: 0.54 кг.
Дата издания: 12.12.2014
Серия: Resistance to targeted anti-cancer therapeutics
Язык: English
Издание: 2015 ed.
Иллюстрации: 2 tables, black and white; 36 illustrations, color; 12 illustrations, black and white; xv, 248 p. 48 illus., 36 illus. in color.
Размер: 165 x 243 x 19
Читательская аудитория: Professional & vocational
Ссылка на Издательство: Link
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Поставляется из: Германии
Описание: This volume provides a comprehensive review of resistance induced by photodynamic therapy (PDT) in tumor cells. Understanding the underlying mechanisms in this process leads to the improvement of therapeutic modality, in combination with chemotherapy, immunotherapy, and radiotherapy. Photodynamic therapy is a minimally invasive therapeutic procedure that can exert a selective or preferential cytotoxic activity toward malignant cells. The procedure involves administration of an intrinsically non-toxic photosensitizing agent (PS) followed by irradiation at a wavelength corresponding to a visible absorption band of the sensitizer. In the presence of oxygen, a series of events lead to direct tumor cell death, damage to the microvasculature, and induction of a local inflammatory reaction. Studies reveal that PDT can be curative, particularly in early stage tumors and this volume explores the potential of PDT, but also reveals strategic approaches to overcome resistance in tumor cells.
Дополнительное описание: Basic and Clinical Aspects of photodynamic Therapy.- Mechanisms of Resistance to Photodynamic Therapy.- Tumor Vascular Microenvironment Determines responsiveness to Photodynamic Therapy.- Autophagy Pathways Activated in Response to PDT Contribute to Cell

Resistance to photodynamic therapy in cancer,