PIPAC: Pressurized IntraPeritoneal Aerosol Chemotherapy – Cancer under Pressure, Marc A. Reymond, Wiebke Solass
Автор: Marc A. Reymond, Wiebke Solass Название: PIPAC: Pressurized IntraPeritoneal Aerosol Chemotherapy – Cancer under Pressure ISBN: 3110345943 ISBN-13(EAN): 9783110345940 Издательство: Walter de Gruyter Цена: 173490.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Peritoneal dissemination is a common route of cancer metastasis. The benefit of administering chemotherapy directly into the peritoneal cavity is supported by preclinical and pharmacokinetic data. In comparison to intravenous (IV) treatment, intraperitoneal (IP) administration results in a several-fold increase in drug concentration within the abdominal cavity. There is now growing evidence from clinical studies showing a survival advantage for IP chemotherapy in various tumor typies, including ovarian, gastric and colorectal cancer.However, while the use of IP chemotherapy is slowly gaining acceptance, it is not universal, largely due to the greater toxicity associated with this approach. Moreover, efficacy of IP chemotherapy is limited by poor distribution within the abdominal cavity and by poor tissue penetration. A new way of IP chemotherapy is the application of cytotoxics in form of a pressurized aerosol into the abdominal of thoracic cavity. Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is applied through laparoscopic access using two balloon trocars in an operating room equipped with laminar air-flow. In a first step,a normothermic capnoperitoneum is established with a pressure of 12 mmHg. A cytotoxic solution (about 10% of a normal systemic dose) is nebulized with a micropump into the abdominal cavity, and maintained for 30 min. The aerosol is then removed through a closed suction system. Applying an aerosol in the peritoneal cavity allows a homogeneous distribution of the chemotherapeutic agent within the abdomen. Furthermore, an artificial pressure gradient is generated that overcomes tumoral interstitial fluid pressure, an obstacle in cancer therapy. This results in a higher local drug concentration compared to conventional IP or IV chemotherapy. At the same time the plasma concentration of the chemotherapeutic agent remains low. In first clinical studies with limited number of patients in ovarian, gastric and colorectal cancer, as well as peritoneal mesothelioma, PIPAC has obtained encouraging tumor response rates and survival, with a low-side effects profile. Larger clinical trials are currently ongoing to examine if these data can be reproduced and extrapolated to other situations.
Автор: C. William Helm; Robert Edwards Название: Intraperitoneal Cancer Therapy ISBN: 1627039570 ISBN-13(EAN): 9781627039574 Издательство: Springer Рейтинг: Цена: 93160.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Intraperitoneal Cancer Therapy investigates intraperitoneal chemotherapy in a variety of complex and interesting ways. The volume details major clinical trails to date, including immunotherapy, hyperthermic treatment of colo-rectal and ovarian cancers. Authors also examine regional approaches to therapy, systemic therapy, and the use of carboplatin and paclitaxel as the standard treatment for women with stages III and IV ovarian cancer. Other chapters also investigate techniques and procedures in treatment, as well as the future direction of both normothermic and hyperthermic intraperitoneal chemotherapy.
Автор: David Alberts; Mary C. Clouser; Lisa M. Hess Название: Intraperitoneal Therapy for Ovarian Cancer ISBN: 3642423574 ISBN-13(EAN): 9783642423574 Издательство: Springer Рейтинг: Цена: 130430.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Intraperitoneal chemotherapy is increasingly being used as first-line treatment for ovarian cancer. Nevertheless, it is difficult for the oncologist to find a definitive text that documents both the fundamental methods required to optimize therapy and the up-to-date results of phase I, II, and III clinical trials. With this in mind, the editors of Intraperitoneal Chemotherapy have assembled a team of highly experienced clinicians and researchers to cover every aspect of the subject. The topics addressed include treatment principles, patient, drug, and catheter selection, administration guidelines, the role of hyperthermia, supportive care requirements, novel drugs, and the most recent results of clinical trials. This book will be an invaluable source of information for both practicing clinical oncologists and oncologists in training.
Автор: M. Hanif Chaudhry; L. Mays Название: Computer Modeling of Free-Surface and Pressurized Flows ISBN: 0792329465 ISBN-13(EAN): 9780792329466 Издательство: Springer Рейтинг: Цена: 491940.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This volume compiles an edited version of the lecture notes specially prepared by 14 European and North American researchers. Part I deals with free-surface flows and part II is related to the modelling of steady and transient pressurized flows.
Автор: M. Alvarez Cuenca; E.J. Anthony Название: Pressurized Fluidized Bed Combustion ISBN: 9401042713 ISBN-13(EAN): 9789401042710 Издательство: Springer Рейтинг: Цена: 348290.00 T Наличие на складе: Есть у поставщика Поставка под заказ.
Название: Pressurized Heavy Water Reactor Fuel: Integrity, Performance and Advanced Concepts: Proceedings of the Technical Meetings Held in Bucharest, 24–27 September 2012, and in Mumbai, 8–11April 2013 ISBN: 9201584148 ISBN-13(EAN): 9789201584144 Издательство: Mare Nostrum (Eurospan) Цена: 16630.00 T Наличие на складе: Невозможна поставка. Описание: This publication is the proceedings of two technical meetings held in 2012 and 2013 on fuel integrity, performances and advanced fuels for pressurized heavy water reactors (PHWRs). The objective of these meetings was to update the information on the performances of PHWR fuels, the status and trends in the use of advanced fuels in PHWRs and the technical readiness for the deployment of such fuel cycles in these types of reactors.
Автор: M. Hanif Chaudhry; L. Mays Название: Computer Modeling of Free-Surface and Pressurized Flows ISBN: 9401044171 ISBN-13(EAN): 9789401044172 Издательство: Springer Рейтинг: Цена: 465840.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Proceedings of the NATO Advanced Study Institute, Pullman, WA, U.S.A., June 28--July 9, 1993
Автор: M. Alvarez Cuenca; E.J. Anthony Название: Pressurized Fluidized Bed Combustion ISBN: 0751402028 ISBN-13(EAN): 9780751402025 Издательство: Springer Рейтинг: Цена: 348290.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Pressurized fluidized bed combustion (PFBC) is a coal-based generation technology. This volume contains a balance of the theoretical and practical aspects of PFBC technology, including economics, the fundamental theory of plant design and sorbent characterization, using the results obtained from pilot-scale and full-scale demonstration units.
Название: Knowledge and Abilities Catalog for Nuclear Power Plant Operators: Westinghouse Ap1000 Pressurized-Water Reactors: Nureg-2103 ISBN: 1249920051 ISBN-13(EAN): 9781249920052 Издательство: Неизвестно Цена: 40150.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The Knowledge and Abilities Catalog for Nuclear Power Plant Operators: Westinghouse AP1000 Pressurized-Water Reactors (NUREG-2103, Revision 0) provides the basis for the development of content-valid licensing examinations for reactor operators (ROs) and senior reactor operators (SROs). The examinations developed using this Catalog along with the Operator Licensing Examination Standards for Power Reactors (NUREG-1021) will sample the topics listed under Title 10, Code of Federal Regulations, Part 55 (10 CFR 55). The catalog is organized into six major sections: Organization of the Catalog, Generic Knowledge and Ability Statements, Plant Systems grouped by safety functions, Emergency and Abnormal Operating Evolutions, Components, and Theory. This is a new Knowledge and Abilities catalog developed specifically to address the passive nature of the Westinghouse AP1000 design.
Казахстан, 010000 г. Астана, проспект Туран 43/5, НП2 (офис 2) ТОО "Логобук" Тел:+7 707 857-29-98 ,+7(7172) 65-23-70 www.logobook.kz
