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PIPAC: Pressurized IntraPeritoneal Aerosol Chemotherapy – Cancer under Pressure, Marc A. Reymond, Wiebke Solass


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Автор: Marc A. Reymond, Wiebke Solass
Название:  PIPAC: Pressurized IntraPeritoneal Aerosol Chemotherapy – Cancer under Pressure
ISBN: 9783110345940
Издательство: Walter de Gruyter
Классификация:



ISBN-10: 3110345943
Обложка/Формат: Hardback
Страницы: 252
Вес: 0.62 кг.
Дата издания: 15.09.2014
Серия: Medicine
Язык: English
Размер: 244 x 175 x 15
Читательская аудитория: Professional and scholarly
Ключевые слова: Clinical & internal medicine, MEDICAL / Chemotherapy,MEDICAL / Gastroenterology,MEDICAL / Surgery / General
Основная тема: MEDICAL / Chemotherapy,MEDICAL / Surgery / General,MEDICAL / Gastroenterology
Ссылка на Издательство: Link
Поставляется из: Германии
Описание: Peritoneal dissemination is a common route of cancer metastasis. The benefit of administering chemotherapy directly into the peritoneal cavity is supported by preclinical and pharmacokinetic data. In comparison to intravenous (IV) treatment, intraperitoneal (IP) administration results in a several-fold increase in drug concentration within the abdominal cavity. There is now growing evidence from clinical studies showing a survival advantage for IP chemotherapy in various tumor typies, including ovarian, gastric and colorectal cancer.However, while the use of IP chemotherapy is slowly gaining acceptance, it is not universal, largely due to the greater toxicity associated with this approach. Moreover, efficacy of IP chemotherapy is limited by poor distribution within the abdominal cavity and by poor tissue penetration. A new way of IP chemotherapy is the application of cytotoxics in form of a pressurized aerosol into the abdominal of thoracic cavity. Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is applied through laparoscopic access using two balloon trocars in an operating room equipped with laminar air-flow. In a first step,a normothermic capnoperitoneum is established with a pressure of 12 mmHg. A cytotoxic solution (about 10% of a normal systemic dose) is nebulized with a micropump into the abdominal cavity, and maintained for 30 min. The aerosol is then removed through a closed suction system. Applying an aerosol in the peritoneal cavity allows a homogeneous distribution of the chemotherapeutic agent within the abdomen. Furthermore, an artificial pressure gradient is generated that overcomes tumoral interstitial fluid pressure, an obstacle in cancer therapy. This results in a higher local drug concentration compared to conventional IP or IV chemotherapy. At the same time the plasma concentration of the chemotherapeutic agent remains low. In first clinical studies with limited number of patients in ovarian, gastric and colorectal cancer, as well as peritoneal mesothelioma, PIPAC has obtained encouraging tumor response rates and survival, with a low-side effects profile. Larger clinical trials are currently ongoing to examine if these data can be reproduced and extrapolated to other situations.

Cancer Chemotherapy in Clinical Practice

Автор: Priestman, Terrence
Название: Cancer Chemotherapy in Clinical Practice
ISBN: 0857297260 ISBN-13(EAN): 9780857297266
Издательство: Springer
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Цена: 55890.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: A simple introduction explaining the broad principles underlying chemotherapy, this book gives trainees a framework within which they can place the specific aspects of cancer chemotherapy they encounter in their everyday experience.

Antibiotic & Chemotherapy

Автор: Roger Finch
Название: Antibiotic & Chemotherapy
ISBN: 0443071292 ISBN-13(EAN): 9780443071294
Издательство: Elsevier Science
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Цена: 190610.00 T
Наличие на складе: Невозможна поставка.
Описание: Offering a globally-relevant account of the properties of various types of antimicrobial agent that are used in human medicine, this book provides guidance on the principles and practice of antimicrobial chemotherapy. It includes extensive chapters on various antiviral, antiprotozoan and anthelminthic agents.

Induction chemotherapy: integrated treatment programs for locally advanced cancers

Автор: Aigner, Karl Reinhard; Stephens, Frederick O. (Eds
Название: Induction chemotherapy: integrated treatment programs for locally advanced cancers
ISBN: 3642181724 ISBN-13(EAN): 9783642181726
Издательство: Springer
Рейтинг:
Цена: 107130.00 T
Наличие на складе: Поставка под заказ.
Описание: Induction chemotherapy, as part of an integrated plan of management for locally advanced cancers, is being practiced throughout the world, but frequently teams are unaware of the work being undertaken in other institutions. This book aims to present the full range of management techniques used in induction chemotherapy within one accessible volume. It provides up-to-date information on pioneering and cutting edge practices and documents the advantages of integrated treatment schedules. Patient selection is discussed, and each of the cancer types for which induction therapy has proved important is considered in detail. All who are responsible for the treatment of patients with locally advanced cancers will find this book to be an invaluable source of information. It will be particularly interesting for specialist oncologists aiming to set up fully comprehensive cancer centers and for health administrators wishing to learn about the benefits of establishing such centers in strategic locations.

Personalized Cancer Chemotherapy

Автор: Da Yong Lu
Название: Personalized Cancer Chemotherapy
ISBN: 0081003463 ISBN-13(EAN): 9780081003466
Издательство: Elsevier Science
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Цена: 154960.00 T
Наличие на складе: Невозможна поставка.
Описание:

Personalized Cancer Chemotherapy separately describes and addresses "individualized cancer chemotherapy" (ICC) strategies new and old, to provide readers with new insights into their characteristics and techniques, as well as key debates and future trends in this area. The book devotes chapters to drug sensitivity testing, cancer biomarkers and bioinformatics detection, pharmacogenetics, individualized antimetastatic therapy, drug combinations, assistant chemotherapy, and cost-effectiveness considerations.

A major obstacle to controlling cancer growth and metastases in patients is the inappropriate use of anticancer and antimetastatic drugs. Researchers and clinicians are now beginning to focus on ICC also called "personalized cancer chemotherapy" (PCC), to improve therapeutic quality and outcomes by selecting and prescribing the most appropriate and effective drugs. Using genetic, molecular, and bioinformatics data and modern experimental techniques, known tumor genes can be detected more easily than ever before; the average speed of genetic sequencing has increased 15,000 to 50,000 times since the Human Geonme Project was completed.

This book will help readers understand the pros and cons of each individualized cancer chemotherapy strategy from different angles so as to make good judgments and predictions of drug responses and clinical outcomes.


  • Explores the central components of cancer treatment
  • Investigates new developments in cancer treatment
  • Discusses the many strategies of individualized cancer chemotherapy

Cancer chemotherapy and biotherapy

Автор: Chabner B.
Название: Cancer chemotherapy and biotherapy
ISBN: 1605474312 ISBN-13(EAN): 9781605474311
Издательство: Lippincott Williams & Wilkins
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Цена: 204770.00 T
Наличие на складе: Невозможна поставка.
Описание: Updated to include the newest drugs and those currently in development, Cancer Chemotherapy and Biotherapy, Fifth Edition is a comprehensive reference on the preclinical and clinical pharmacology of anticancer agents. Organized by drug class, the book pro

Cancer Chemotherapy and Biotherapy

Автор: Chabner
Название: Cancer Chemotherapy and Biotherapy
ISBN: 0781756286 ISBN-13(EAN): 9780781756280
Издательство: Lippincott Williams & Wilkins
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Цена: 160160.00 T
Наличие на складе: Невозможна поставка.
Описание: "Updated to include the newest drugs and those currently in development, this Fourth Edition is a comprehensive reference on the preclinical and clinical pharmacology of anticancer agents. Organized by drug class, the book provides the latest information on all drugs and biological agents--their mechanisms of action, interactions with other agents, toxicities, side effects, and mechanisms of resistance. The authors explain the rationale for use of drugs in specific schedules and combinations and offer guidelines for dose adjustment in particular situations. This edition provides expanded coverage of monoclonal antibodies, molecularly targeted drugs, vaccines, cell based therapies, growth factors, and pharmacogenetics.

Royal Marsden Hospital Handbook of Cancer Chemotherapy

Автор: David Brighton
Название: Royal Marsden Hospital Handbook of Cancer Chemotherapy
ISBN: 0443071012 ISBN-13(EAN): 9780443071010
Издательство: Elsevier Science
Рейтинг:
Цена: 71710.00 T
Наличие на складе: Невозможна поставка.
Описание: This will be an invaluable resource for all levels of health and social care professionals wanting to learn or set up best practice for adult and paediatric patients undergoing chemotherapy. The book will provide the user with a traditional wide-ranging text on chemotherapy from an interdisciplinary approach. The CD-ROM will include the majority of the information from the book, with the addition of multimedia elements to enhance the users understanding of the subject - this will be approximately 25 minutes of video on important aspects such as cannulation, giving intravenous drugs.

The Cancer Chemotherapy Handbook 6e

Автор: David Fischer
Название: The Cancer Chemotherapy Handbook 6e
ISBN: 0323018904 ISBN-13(EAN): 9780323018906
Издательство: Elsevier Science
Рейтинг:
Цена: 62870.00 T
Наличие на складе: Невозможна поставка.
Описание: This pocket-sized reference is a practical guide to the care and treatment of cancer patients. It contains the most comprehensive list of chemotherapeutic drugs, including biological response modifiers, available anywhere. Each drug profile follows a uniform format, discussing mechanisms of action, indications, metabolism, dose, administration, drug interactions, incompatibilities, and toxicity. Cancer treatment protocols are arranged by cancer type. Completely, revised, and updated, the 6th Edition features 100 new chemotherapeutic drugs, as well as new information on medication errors and safety, and monoclonal antibodies.

Handbook of Cancer Chemotherapy 8ed

Автор: Skeel
Название: Handbook of Cancer Chemotherapy 8ed
ISBN: 160831782X ISBN-13(EAN): 9781608317820
Издательство: Lippincott Williams & Wilkins
Рейтинг:
Цена: 67490.00 T
Наличие на складе: Невозможна поставка.
Описание: Skeel's Handbook of Cancer Chemotherapy combines in one place the most current rationale and specific details necessary to safely administer chemotherapy for most adult cancers. The handbook is a practical, diseased-focused pocket reference that emphasizes the best current medical practice as it relates to the delivery of chemotherapeutic drugs. By focusing on specific plans for treatment, the book is an invaluable resource for the daily care of cancer patients.

Antimicrobial Chemotherapy 5/e P. 2007

Автор: Greenwood
Название: Antimicrobial Chemotherapy 5/e P. 2007
ISBN: 0198570163 ISBN-13(EAN): 9780198570165
Издательство: Oxford Academ
Рейтинг:
Цена: 42190.00 T
Наличие на складе: Поставка под заказ.
Описание: Aims to encourage good prescribing habits in doctors throughout the world, by describing the basic properties of antibiotics and other antimicrobial agents, and discussing the principles underlying the rational use of antimicrobial agents in the management of infection.

Antimicrobial Chemotherapy

Автор: Finch, Roger; Davey, Peter; Wilcox, Mark H.; Irvin
Название: Antimicrobial Chemotherapy
ISBN: 0199697655 ISBN-13(EAN): 9780199697656
Издательство: Oxford Academ
Цена: 42230.00 T
Наличие на складе: Поставка под заказ.
Описание: Antimicrobial agents are essential for the treatment of life-threatening infections and for managing the burden of minor infections in the community. In addition, they play a key role in organ and bone marrow transplantation, cancer chemotherapy, artificial joint and heart valve surgery. Unlike other classes of medicines, they are vulnerable to resistance from mutations in target microorganisms, and their adverse effects may extend to other patients (increased risk of cross-infection). As a consequence, there is a constant requirement for new agents, as well as practices that ensure the continued effective prescribing of licensed agents. Public awareness and concerns about drug resistant organisms has led to widespread publicity and political action in the UK, Europe and worldwide. The control of drug resistance and the implementation of good prescribing practice are now legal requirements in the UK as a result of the UK Health Act (2008). These fundamental changes underscore the ne


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