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Biochemistry, Biosynthesis and Human Diseases, Tracey Rouault


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Автор: Tracey Rouault
Название:  Biochemistry, Biosynthesis and Human Diseases
ISBN: 9783110479393
Издательство: Walter de Gruyter
Классификация:



ISBN-10: 3110479397
Обложка/Формат: Hardcover
Страницы: 491
Вес: 0.98 кг.
Дата издания: 25.09.2017
Серия: Chemistry
Язык: English
Размер: 244 x 170 x 27
Читательская аудитория: Professional and scholarly
Ключевые слова: Inorganic chemistry,Biochemistry, SCIENCE / Chemistry / Inorganic,SCIENCE / Life Sciences / Biochemistry,SCIENCE / Life Sciences / Microbiology,SCIENCE / Life Sciences / Molecular Biology
Поставляется из: Германии
Описание: This volume on iron-sulfur proteins includes chapters that discuss how microbes, plants, and animals synthesize these complex prosthetic groups, and why it is important to understand the chemistry and biogenesis of iron sulfur proteins. In addition to their vital importance in mitochondrial respiration, numerous iron sulfur proteins are important in maintenance of DNA integrity. Multiple rare human diseases with different clinical presentations are caused by mutations of genes in the iron sulfur cluster biogenesis pathway. Understanding iron sulfur proteins is important for understanding a rapidly expanding group of metabolic pathways important in all kingdoms of life, and for understanding processes ranging from nitrogen fixation to human disease.

Lignin: Biosynthesis, Functions and Economic Significance

Автор: Fachuang Lu, Fengxia Yue
Название: Lignin: Biosynthesis, Functions and Economic Significance
ISBN: 1536147699 ISBN-13(EAN): 9781536147698
Издательство: Nova Science
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Описание: Lignin is the main natural resource of aromatic structures on Earth. With the depletion of fossil oil and increased environmental concerns, renewable resources for energy and chemical production have attracted tremendous attention from scientists and engineers. As a renewable aromatic polymer, lignin has been, for a long time, studied in terms of its biosynthesis, structures, reactivities and applications although few portions of lignins available from the industry, mainly pulping mills, have been utilized for various applications. The key for complete and efficient utilization of lignins is that all aspects, including lignin biosynthesis, structures, functionalities, and properties, about lignins should be understood. Another important attribute related to lignin utilization comes from analytical methods essential for our understanding of lignins and mechanisms involved in various processes. This book provides critical reviews and the latest research results relating to selected fields of lignin biosynthesis, functional characterization and applications.

Natural Product Biosynthesis: Chemical Logic and Enzymatic Machinery

Автор: Walsh Christopher T., Tang Yi
Название: Natural Product Biosynthesis: Chemical Logic and Enzymatic Machinery
ISBN: 1788010760 ISBN-13(EAN): 9781788010764
Издательство: Marston Book Services
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Цена: 118790.00 T
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Описание: This textbook describes the types of natural products, the biosynthetic pathways that enable the production of these molecules, and an update on the discovery of novel products in the post-genomic era.

Function and Biosynthesis of Lipids

Автор: N. Bazan
Название: Function and Biosynthesis of Lipids
ISBN: 1468432788 ISBN-13(EAN): 9781468432787
Издательство: Springer
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Цена: 93160.00 T
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Polyhydroxyalkanoates: Biosynthesis, Chemical Structures and Applications

Автор: Harvey Williams, Patricia Kelly
Название: Polyhydroxyalkanoates: Biosynthesis, Chemical Structures and Applications
ISBN: 1536134392 ISBN-13(EAN): 9781536134391
Издательство: Nova Science
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Описание: Polyhydroxyalkanoates: Biosynthesis, Chemical Structures and Applications opens with an expose on employing extremophiles as polyhydroxyalkanoate (PHA) producers. The authors suggest that extremophiles may be easily subjected to a long-term continuous cultivation processes, which considerably enhances overall productivity while reducing the energy demand in biopolymer production. Conversely, a range of challenges remain, including improving the metabolic capability of extremophiles, recycling of fermentation broth, various process engineering aspects, and adaptation of bioreactor materials and process controlling devices to conditions shortening their life span. Following this, the enzymes, regulators and genes involved in PHA biosynthesis are analyzed for their potential as an alternative to synthetic polymers. They are synthesized as intracellular carbon and energy storage compounds from over 300 species in the presence of excess carbon and under oxygen, nitrogen or phosphorus limitation, or after pH shifts. This collection goes on to suggest PHA as a promising alternative for petrochemical compounds. The challenges of increasing economic feasibility in the global market, minimizing costs, and improving the polymer yield are reviewed. Additionally, recent research on structural variations of PHAs has been centered on the design, biosynthesis, and properties of biodegradable and biocompatible materials, which can be used for bioengineering. This collection also includes a focus on the roles of polyhydroxyesters and PHAs in the construction of tissue engineering scaffolds, which are used in bone, cartilage, ligament, skin, vascular tissues, neural tissues and skeletal muscles. Their exceptional properties, such as high surface-to-volume ratio, high porosity with very small pore size, and biodegradation have made them gain a lot of attention in this field. The biomedical applications of PHAs are explored, including in-vivo implants, tissue engineering, anticancer agents, drug delivery, biocontrol agents and memory enhancers, as their low acidity allows for minimal risk in usage. In order to enhance its applicability in various fields, the blends and nanocomposites of PHAs are studied and their potential challenges, applications and opportunities are addressed. After which, the industrial and agricultural applications are described, with specific focus on potential applications of PHAs in packaging. Other applications include moulded goods, paper coatings, non-woven fabrics, adhesives, films and performance additives. Recent advances in this area, by means of peer-reviewed literature and patents, are introduced and discussed. Moreover, innovative strategies for the synthesis of novel polymer blends, adequate for food contact applications, are presented.

Nonribosomal Peptide and Polyketide Biosynthesis

Автор: Bradley Evans
Название: Nonribosomal Peptide and Polyketide Biosynthesis
ISBN: 1493980343 ISBN-13(EAN): 9781493980345
Издательство: Springer
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Цена: 93160.00 T
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Описание:

Part I: Background and Overview

1. Structural Biology of Nonribosomal Peptide Synthetases

Bradley R. Miller and Andrew M. Gulick

2. The Assembly Line Enzymology of Polyketide Biosynthesis

Marisa Till and Paul R. Race

Part II: In Vitro Methods

3. Measurement of Nonribosomal Peptide Synthetase Adenylation Domain Activity Using a Continuous Hydroxylamine Release Assay

Benjamin P. Duckworth, Daniel J. Wilson, and Courtney C. Aldrich

4. Affinity Purification Method for the Identification of Nonribosomal Peptide Biosynthetic Enzymes Using a Synthetic Probe for Adenylation Domains

Fumihiro Ishikawa and Hideaki Kakeya

5. Colorimetric Detection of the Adenylation Activity in Nonribosomal Peptide Synthetases

Chitose Maruyama, Haruka Niikura, Masahiro Takakuwa, Hajime Katano, and Yoshimitsu Hamano

6. Facile Synthetic Access to Glycopeptide Antibiotic Precursor Peptides for the Investigation of Cytochrome P450 Action in Glycopeptide Antibiotic Biosynthesis

Clara Brieke, Veronika Kratzig, Madeleine Peschke, and Max J. Cryle

7. Reconstitution of Fungal Nonribosomal Peptide Synthetases in Yeast and In Vitro

Ralph A. Cacho and Yi Tang

8. The Continuing Development of E. coli as a Heterologous Host for Complex Natural Product Biosynthesis

Haoran Zhang, Lei Fang, Marcia S. Osburne, and Blaine A. Pfeifer

9. Screening for Expressed Non

ribosomal Peptide Synthetases and Polyketide Synthases Using LC‒MS/MS-Based Proteomics

Yunqiu Chen, Ryan A. McClure, and Neil L. Kelleher

10. Enhancing Nonribosomal Peptide Biosynthesis in Filamentous Fungi

Alexandra A. Soukup, Nancy P. Keller, and Philipp Wiemann

11. In Situ Analysis of Bacterial Lipopeptide Antibiotics by Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging

Delphine Debois, Marc Ongena, Hйlиne Cawoy, and Edwin De Pauw

12. Secondary Metabolic Pathway-Targeted Metabolomics

Maria I. Vizcaino and Jason M. Crawford

Part III: Bioinformatic Methods

13. Annotating and Interpreting Linear and Cyclic Peptide Tandem Mass Spectra

14. Bioinformatics Tools for the Discovery of New Nonribosomal Peptides

Valйrie Leclиre, Tilmann Weber, Philippe Jacques, and Maude Pupin

15. The Use of ClusterMine360 for the Analysis of Polyketide and Nonribosomal Peptide Biosynthetic Pathways

Nicolas Tremblay, Patrick Hill, Kyle R. Conway, and Christopher N. Boddy

16. Alignment-Free Methods for the Detection and Specificity Prediction of Adenylation Domains

Guillermin Agьero-Chapin, Gisselle Pйrez-Machado, Aminael Sбnchez-Rodrнguez, Miguel Machado Santos, and Agostinho Antunes

17. Characterization of Nonribosomal Peptide Synthetases with NRPSsp

C

arlos Prieto


The Biosynthesis of Secondary Metabolites

Автор: R.B. Herbert
Название: The Biosynthesis of Secondary Metabolites
ISBN: 0412277204 ISBN-13(EAN): 9780412277207
Издательство: Springer
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Описание: Investigation of secondary metabolism began with curiosity about the structures of compounds isolated from natural sources, i.e. Coeval with structure determination there has been a curiosity about the origins and mechanism of formation of secondary metabolites (or natural products as they have been called).


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