Concepts in Clinical Pharmacokinetics, Robin Southwood, Virginia H. Fleming, Gary Huckaby

Автор: Bauer
Название: Handbook of clinical pharmacokinetics
ISBN: 007142542X ISBN-13(EAN): 9780071425421
Издательство: McGraw-Hill
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Цена: 42310.00 T
Наличие на складе: Поставка под заказ.
Описание: Designed for pharmacists and clinicians responsible for adjusting drug dosages based on the patient blood serum concentrations and other parameters, this indispensable, portable reference offers a variety of ways to perform pharmacokinetic calculations. It also features calculation methods, algorithms for choosing the best calculation method, and case studies.

Автор: Bonate Peter, Howard Danny
Название: Pharmacokinetics in Drug Development / Clinical Study Design and Analysis (Volume 1)
ISBN: 0971176744 ISBN-13(EAN): 9780971176744
Издательство: Springer
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Цена: 204970.00 T
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Описание: These volumes are designed to be the most complete guide to pharmacokinetics (PK) and its role in drug development. Geared toward graduate level students and scientists in the areas of clinical pharmacology and PK, the volumes will fill a gap between the academic science and the practical application of that knowledge in drug development. Volume 1 discusses the role that PK plays in selected clinical study designs, including first-time-in-man, biopharmaceuticals, and special population studies. Volume 2 details the key regulatory and development paradigms in which PK supplements decision-making during drug development.

Автор: Bauer
Название: Applied Clinical Pharmacokinetics
ISBN: 0071794581 ISBN-13(EAN): 9780071794589
Издательство: McGraw-Hill
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Цена: 84650.00 T
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Описание: Helps you learn the clinical application of pharmacokinetics. This book delivers clear and clinically relevant coverage of drug dosing and drug monitoring that no other text can match. It offers the standardized techniques and approaches to patient-specific dosing, and information on pharmacokinetically monitored drugs.

Автор: Thorsteinn Loftsson
Название: Essential Pharmacokinetics
ISBN: 0128014113 ISBN-13(EAN): 9780128014110
Издательство: Elsevier Science
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Цена: 59890.00 T
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Описание: Essential Pharmacokinetics: A Primer for Pharmaceutical Scientists is an introduction to the concepts of pharmacokinetics intended for graduate students and new researchers working in the pharmaceutical sciences. This book describes the mathematics used in the mammillary model as well as the application of pharmacokinetics to pharmaceutical product development, and is useful as both a self-study and classroom resource. Content coverage includes detailed discussions of common models and important pharmacokinetic concepts such as biological half-life, clearance, excretion, multiple dosage regimens and more. Numerous equations, practical examples and figures are incorporated to clearly illustrate the theoretical background of pharmacokinetic behavior of drugs and excipients.

Автор: Devarakonda R. Krishna; Ulrich Klotz
Название: Clinical Pharmacokinetics
ISBN: 3540524584 ISBN-13(EAN): 9783540524588
Издательство: Springer
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Цена: 102480.00 T
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Описание: 2 Multiple dosing The basic mathematical relationships applicable to single dose administration kinetics are also valid (with slight modifications) for multiple dose kinetics.

Автор: Bauer
Название: Appl. Clinical Pharmacokinetics.2001
ISBN: 0838503888 ISBN-13(EAN): 9780838503881
Издательство: McGraw-Hill
Цена: 32020.00 T
Наличие на складе: Невозможна поставка.
Описание: Improving upon and updating the information and format of the leading competing clinical pharmacokinetic text, Dr. Bauer, a nationally recognized leader in the field of pharmacokinetics has conceived a text for today and tomorrow's pharmacy student and practitioner. The text emphasizes the practical aspects of drug dosing for agents that have serum concentrations commonly available from clinical laboratories. Filling a hole in our list between Shargel and Schumacher, this new book will focus on patient specific drug dosing, thereby emphasizing the standard clinical pharmacokinetic dosing techniques.

Автор: Winter
Название: Basic Clinical Pharmacokinetics
ISBN: 0781741475 ISBN-13(EAN): 9780781741477
Издательство: Lippincott Williams & Wilkins
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Цена: 41750.00 T
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Описание: Basic Clinical Pharmacokinetics was designed to simplify pharmacokinetics to help busy practitioners understand and visualize basic principles. An easy-to-read, case-study format has made the text a favorite among clinical professors, students, and practitioners. The text provides an introduction to the principles of monitoring drug therapy for those involved in the interpretation of drug levels in a patient care setting. Part One provides a basic review of pharmacokinetic principles. Extensive explanations, graphic illustrations, and detailed algorithms teach the principles of bioavailability, volume of distribution, clearance, elimination rate constant, and half-life. Part Two explains the clinical applications of these principles. Solutions to problems commonly encountered in the practice setting are discussed for specific drugs. Appendices provide commonly used equations and a glossary of pharmacokinetic terms and abbreviations. New to this edition are chapters on tricyclic antidepressants and cyclosporine, an expanded chapter on dialysis, and updated information on choosing equations and interpreting plasma drug concentrations.

Автор: Juan M Coello, Yolanda D Sabres
Название: Vincristine: Clinical Uses, Pharmacokinetics & Impacts on Health
ISBN: 1628088869 ISBN-13(EAN): 9781628088861
Издательство: Nova Science
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Цена: 103480.00 T
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Описание: The purpose of this work is to improve service learning research and practice through strengthening its theoretical base. The authors bring theoretical perspectives from a wide variety of disciplines to bear as they critically review past research, describe assessment methods and instruments, develop future research agendas, and consider implications of theory-based research for enhanced practice.

Автор: Andrea Angelini
Название: Voriconazole: Pharmacokinetics, Role in Therapeutic Drug Monitoring & Clinical Outcomes
ISBN: 163463313X ISBN-13(EAN): 9781634633130
Издательство: Nova Science
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Цена: 224920.00 T
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Описание: In the last twenty years, the incidence of invasive fungal infections (IFI) has risen dramatically due to the prolongation of survival of patients with multiple risk factors for fungal infections and due to the increase of infection associated with travel. Moreover IFI in infants admitted to the neonatal intensive care unit are common and often fatal. Amphotericin B was for more than 40 years the gold standard for almost all IFI, but toxicity and resistance, especially of new and emerging pathogens remained important issues. Fluconazole and itraconazole have also the same disadvantage of resistance. After a long period of relative inactivity in the introduction of new antifungals, more recently a few new drugs of already existing classes have been introduced as important agents in the treatment and prevention of IFI. These represent small or large advantages and differences compared with existing available alternative therapy for deep and systemic mycoses. Voriconazole is a second-generation triazole antifungal drug, often prescribed as first-line therapy for candidemia, in non-neutropenic hosts, for invasive pulmonary aspergillosis and as prophylaxis of many systemic mycoses. In-vitro and in-vivo studies showed that voriconazole has broad-spectrum activity against most Candida species, Aspergillus species, fusariosis or scedosporiosis. Voriconazole has non-linear pharmacokinetics and, as substrate and inhibitor of cytochrome P450, it undergoes extensive hepatic metabolism that depends on age, genetic factors, and interactions with other drugs, which may lead to enhanced toxicity of the concomitant medication(s) or ineffective antifungal treatment. This book presents an update on voriconazole research, particularly its pharmacology, microbiology, toxicology, and clinical outcomes in order to optimize its use in daily clinical practice.