Voltage-gated Sodium Channels: Structure, Function and Channelopathies, Chahine

Название: Receptor and Ion-channel Trafficking: Cell Biology of Ligand-gated and Voltage-sensitive Ion Channels
ISBN: 0192632248 ISBN-13(EAN): 9780192632241
Издательство: Oxford Academ
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Цена: 250800.00 T
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Описание: This book reviews the recent advances in our understanding of the the molecular and cellular mechanisms regulating the targeted movement (trafficking) of receptors and ion channels in neurones - mechanisms fundamental to synaptic function.

Автор: Peter C. Ruben
Название: Voltage Gated Sodium Channels
ISBN: 3642415873 ISBN-13(EAN): 9783642415876
Издательство: Springer
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Цена: 307450.00 T
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Описание: A number of techniques to study ion channels have been developed since the electrical basis of excitability was first discovered. Ion channel biophysicists have at their disposal a rich and ever-growing array of instruments and reagents to explore the biophysical and structural basis of sodium channel behavior. Armed with these tools, researchers have made increasingly dramatic discoveries about sodium channels, culminating most recently in crystal structures of voltage-gated sodium channels from bacteria. These structures, along with those from other channels, give unprecedented insight into the structural basis of sodium channel function. This volume of the Handbook of Experimental Pharmacology will explore sodium channels from the perspectives of their biophysical behavior, their structure, the drugs and toxins with which they are known to interact, acquired and inherited diseases that affect sodium channels and the techniques with which their biophysical and structural properties are studied.

Автор: Peter C. Ruben
Название: Voltage Gated Sodium Channels
ISBN: 3662512025 ISBN-13(EAN): 9783662512029
Издательство: Springer
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Цена: 287330.00 T
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Описание: This volume of Springer`s Handbook of Experimental Pharmacology explores the wide range of factors relating to sodium channels, from their biophysical behavior, structure, and pathological vulnerabilities to the methodologies employed in studying them.

Автор: Gerald Werner Zamponi
Название: Voltage-Gated Calcium Channels
ISBN: 1441934111 ISBN-13(EAN): 9781441934116
Издательство: Springer
Цена: 191550.00 T
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Описание: oltage-gated calcium channels are essential mediators of a range of physiological functions, including the communication between nerve Vcells, the regulation of heart beat, muscle contraction, and secretion of hormones such as insulin. Consequently, these channels are critical phar- macological targets in the treatment of a variety of disorders, such as epi- lepsy, hypertension, and pain. Voltage-gated calcium channels have there- fore been subject to intense study by numerous investigators over the past few decades, and an immense body of work has accumulated. In this book, we provide the first comprehensive overview of our current state of knowl- edge concerning this exciting field of research. Leading off with a general review of calcium signaling and techniques to measure calcium channel ac- tivity, the book delves into a provocative overview of the history of the cal- cium channel field, contributed by one of the key pioneers in the field. Dr. Richard Tsien. This is followed by an in depth review of the biochemical and molecular biological characterization of calcium channel genes by Drs. Catterall and Snutch whose research has resulted in major advances in the calcium channel field. A number of chapters are dedicated towards various aspects of calcium channel structure and function, including channel gat- ing, permeation, modulation and interactions with members of the exo- totic machinery--contributed by both established leaders and rising stars in the field.