Immune Deficiency and Cancer, David T. Purtilo

Автор: Joseph Lustgarten; Yan Cui; Shulin Li
Название: Targeted Cancer Immune Therapy
ISBN: 1493939912 ISBN-13(EAN): 9781493939916
Издательство: Springer
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Цена: 204970.00 T
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Описание: Stimulation of the immune system’s ability to control and destroy tumors cont- ues to be the goal of cancer immune therapy; but the scope has rapidly expanded; approaches are constantly updated; new molecules are continually introduced; and immune mechanisms are becoming better understood. This book has no intention of covering every aspect of immune therapy but rather focuses on the novelty of cancer immune therapy in an attempt to give readers an opportunity to absorb the new aspects of immune therapy from a single source. In this regard, three areas were selected: cytokine immune therapy, cell-based immune therapy, and targeted immune therapy. In each of these three sections, only the novel aspects of immune therapy were described instead of attempting to cover any historical achievement. In the first section, Cytokine Immune Therapy, the IL12 family, IL18, IL21, IL24, IL28, and IL29 were emphasized in regard to the an- tumor function and application in treating tumors. Most of these selected cyt- ines were discovered in last 10 years. In the second section, Cell-based Immune Therapy, the focus was engineering potent immune regulatory or effector cells such as dendritic cells, T cells, and stem cells. Cell engineering design is primarily based on the increased understanding of the interaction of tumor antigen-presenting cells, antigen- specific effector cells, and the tumor microenvironment.

Автор: Rong-Fu Wang
Название: Innate Immune Regulation and Cancer Immunotherapy
ISBN: 1489985905 ISBN-13(EAN): 9781489985903
Издательство: Springer
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Цена: 174130.00 T
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Описание: Innate and adaptive immunity play important roles in immunosurveillance and tumor destruction. This book discusses recent progress in innate immunity and Treg cells, and the regulation of innate immunity through Toll-like receptor (TLR) signalling.

Автор: Akihiko Yoshimura
Название: Emerging Concepts Targeting Immune Checkpoints in Cancer and Autoimmunity
ISBN: 3319689282 ISBN-13(EAN): 9783319689289
Издательство: Springer
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Цена: 158380.00 T
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Описание: Further, the volume examines other agents, a number of cells, receptors and signaling molecules, that are also involved in the regulation of T-cell activation and extends the concept of immune checkpoints to "molecules and cells that negatively regulate T-cell activation".

Автор: Kalinski
Название: Tumor Immune Microenvironment in Cancer Progression and Cancer Therapy
ISBN: 3319675753 ISBN-13(EAN): 9783319675756
Издательство: Springer
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Цена: 167700.00 T
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Описание: The tumor microenvironment has become a very important and hot topic in cancer research within the past few years. The tumor microenvironment is defined as the normal cells, molecules, and blood vessels that surround and feed a tumor cell. As many scientists have realized, studying the tumor microenvironment has become critical to moving the field forward, since there are many players in a tumor’s localized and surrounding area, which can significantly change cancer cell behavior. There is a dual relationship wherein the tumor can change its microenvironment and the microenvironment can affect how a tumor grows and spreads. Tumor Microenvironment in Cancer Progression and Cancer Therapy aims to shed light on the mechanisms, factors, and mediators that are involved in the cancer cell environment. Recent studies have demonstrated that in addition to promoting tumor progression and protecting tumor cells from the spontaneous immune-mediated rejection and different forms of cancer therapeutics, tumor microenvironment can also be a target and mediator of both standard and newly-emerging forms of cancer therapeutics. Thus, the dual role of the tumor microenvironment is the integral focus of the volume.  The volume highlights the bi-directional interactions between tumor cells and non-malignant tumor component during tumor progression and treatment. It also focuses on the three groups of the reactive tumor component: stromal cells, blood vessels and the infiltrating immune cells. These three groups are discussed under the lens of their role in promoting tumor growth, shielding the tumor from rejection and from standard forms of cancer therapies. They are emerging as targets and mediators of standard and new forms of potential therapy.

Автор: Barbara Stefanska; David J. MacEwan
Название: Epigenetics and Gene Expression in Cancer, Inflammatory and Immune Diseases
ISBN: 149396741X ISBN-13(EAN): 9781493967414
Издательство: Springer
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Цена: 121110.00 T
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Описание: This practical collection examines methodologies originating from the benefits of genome-wide approaches to studying epigenetics, which has opened the emerging field of epigenomics. Focusing on the areas of cancer, inflammatory and autoimmune disorders, chapters discuss three main components of the epigenome and their role in the regulation of gene expression and present a detailed method section specific to studying each component, including data analyses, troubleshooting, and feasibility in different experimental settings. The main topics are high-throughput and targeted methods for DNA methylation analysis, nucleosome position mapping, studying epigenetic effects of gut microbiota, optical imaging for detection of epigenetic aberrations in living cells, methods for microRNA, and histone code profiling. Written for the Methods in Pharmacology and Toxicology series, the book includes the kind of detail and implementation advice to encourage success in the lab.

Автор: Hans E. Kaiser; N.A. Nasir; Aejaz Nasir
Название: Selected Aspects of Cancer Progression: Metastasis, Apoptosis and Immune Response
ISBN: 9048177065 ISBN-13(EAN): 9789048177066
Издательство: Springer
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Цена: 174130.00 T
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Описание: The processes of tumor metastasis, apoptosis and anti-tumor immune response are among the most complex yet rapidly advancing fields in the area of cancer research. This monograph, with its leading authorship, presents a comprehensive coverage of the recent advances in the various key concepts in these fundamental aspects of human cancer.

Автор: Fernando Salinas
Название: Immune Complexes and Human Cancer
ISBN: 1468449338 ISBN-13(EAN): 9781468449334
Издательство: Springer
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Цена: 46570.00 T
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Описание: Immune Complexes and Human Cancer, the fifteenth volume of Contem- porary Topics in Immunobiology, is a compilation of information derived from recent studies on the role of circulating immune complexes (CIC) in the patho- genic manifestations of a variety of human cancers.