Biological Markers of Alzheimer`s Disease, Francois Boller; Robert Katzman; Andre Rascol; Jea

Автор: Farooqui, Akhlaq A.
Название: Neurochemical Aspects of Alzheimer Disease
ISBN: 0128099372 ISBN-13(EAN): 9780128099377
Издательство: Elsevier Science
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Цена: 88650.00 T
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Описание:

Neurochemical Aspects of Alzheimer's Disease provides a comprehensive overview of molecular aspects of risk factors, pathogenesis, biomarkers, and therapeutic strategies. The book focuses on molecular mechanisms and signal transduction processes associated with the pathogenesis, biomarkers, and therapeutic strategies of AD. The comprehensive and cutting edge information in this monograph may not only help in early detection of AD, but also promote discovery of new drugs to treat this chronic disease. Chapters discuss involvement of neural membrane phospholipids, sphingolipids, and cholesterol-derived lipid mediators, abnormal APP processing, and nucleic acid damage, risk factors, biomarker, and therapeutic strategies of Alzheimer's disease. This book is written for neurologists, neuroscientists, neurochemists, neuropharmacologists, and clinicianswho are interested in molecular mechanisms associated with the pathogenesis of age-related neurological disorders.

Автор: Steven G. Younkin; Rudolph E. Tanzi
Название: Presenilins and Alzheimer`s Disease
ISBN: 3642721052 ISBN-13(EAN): 9783642721052
Издательство: Springer
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Цена: 130610.00 T
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Описание: The role of the familial Alzheimer`s Disease genes called "presenilins" in causing neuronal cell death and Alzheimer-related pathology.

Автор: Yoshikuni Mizuno; Abraham Fisher; Israel Hanin
Название: Mapping the Progress of Alzheimer`s and Parkinson`s Disease
ISBN: 1475709730 ISBN-13(EAN): 9781475709735
Издательство: Springer
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Цена: 174150.00 T
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Описание: 1h The 5 International Conference on the Progress in Alzheimer`s Disease and Parkinson`s 51 1 Disease took place from March 31 to April 5 \ 2001 in Kroto, Japan. This international 1 conference was organized as a joint Congress with the 9 International Catecholamine Symposium.

Автор: Bradley T. Hyman; Jean-Francois Demonet
Название: The Living Brain and Alzheimer`s Disease
ISBN: 3642639275 ISBN-13(EAN): 9783642639272
Издательство: Springer
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Цена: 113190.00 T
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Описание: From large cross-sectional studies of autopsy material, it seems as if a time course of Alzheimer`s Disease, at least on average, can be mapped out: a pattern of hierarchical vulnerability for neuronal loss and neurofibrillary tangles beginning in medial temporal lobe structures proceeding through association areas.

Автор: Philippe Dostert; Peter Riederer; Margherita Strol
Название: Early Markers in Parkinson`s and Alzheimer`s Diseases
ISBN: 3709191009 ISBN-13(EAN): 9783709191002
Издательство: Springer
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Цена: 81050.00 T
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Описание: The aim of Early Markers in Parkinson`s and Alzheimer`s Diseases is to provide the reader with updated data on various approaches whose investigation and development could contribute to the discovery of early diag- nostic markers of these two degenerative diseases.

Автор: Francisco Gonzalez-Lima
Название: Cytochrome Oxidase in Neuronal Metabolism and Alzheimer`s Disease
ISBN: 1475799381 ISBN-13(EAN): 9781475799385
Издательство: Springer
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Цена: 214280.00 T
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Описание: Proceedings of an International Symposium held in New Orleans, Louisiana, October 28, 1997

Автор: Ralph W. Richter; Brigitte Zoeller Richter
Название: Alzheimer`s Disease
ISBN: 1475744854 ISBN-13(EAN): 9781475744859
Издательство: Springer
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Цена: 93160.00 T
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Описание: Alzheimer`s disease (AD) is a devastating and dehumanizing illness affecting increasingly large numbers of elderly and even middle-aged persons in a worldwide epidemic.

Автор: A.D. Roses; K.H. Weisgraber; Y. Christen
Название: Apolipoprotein E and Alzheimer`s Disease
ISBN: 3642801110 ISBN-13(EAN): 9783642801112
Издательство: Springer
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Цена: 121110.00 T
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Описание: There is now considerable genetic evidence that the type 4 allele of the apolipoprotein E gene is a major susceptibility factor associated with late- onset Alzheimer's disease, the common form of the disease defined as starting after 60 years of age. The roles of apolipoprotein E in normal brain metabo- lism and in the pathogenesis of Alzheimer's disease are new and exciting avenues of research. This is why the Fondation Ipsen organised an interna- tional meeting on this topic in Paris on May 29,1995, and the proceedings are contained in this book. The editors wish to thank Mrs Mary Lynn Gage for editorial and Mrs Jacqueline Mervaillie for the organization of the meeting in Paris. Allen Roses Karl Weisgraber Yves Christen Contents Apolipoprotein E and Alzheimer's Disease: State of the Field After Two Years A. D. Roses, W. I. Strittmatter, A. M. Saunders, D. E. Schmechel, and M. A. Pericak-Vance. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Role of Apolipoprotein E in Alzheimer's Disease: Clues from its Structure KH. Weisgraber and L. M Dong . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11 Apolipoprotein E4, Cholinergic Integrity, Synaptic Plasticity and Alzheimer's Disease I. Poirier, M-C. Delisle, R. Quirion, I. Aubert, I. Rocheford, I. Rousse, S. Gracon, M. Farlow, and S. Gauthier. . . . . . . . . . . . . . . . . . . 20 Pattern of Apolipoprotein E Immunoreactivity During Brain Aging D. E. Schmechel, MO. Tiller, P. Tong, M McSwain, S. -H. Han, R. Ange, D. S. Burkhart, and MK Izard. . . . . . . . . . . . . . . . . . . . . . . . . . .

Автор: F.H. Gage; A. Privat
Название: Neuronal Grafting and Alzheimer`s Disease
ISBN: 3642483712 ISBN-13(EAN): 9783642483714
Издательство: Springer
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Цена: 46570.00 T
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Описание: An answer to the question, whether neuronal grafting will be useful as a therapy for Alzheimer`s disease, must wait for a better understanding of the disease and the identification of animal models that can be used to test potential therapies.

Автор: J.D. Turner; K. Beyreuther; F. Theuring
Название: Alzheimer`s Disease
ISBN: 3662032503 ISBN-13(EAN): 9783662032503
Издательство: Springer
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Цена: 46570.00 T
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Описание: Alzheimer`s Disease is a progressive neurodegenerative disorder of late life with devastating consequences for the afflicted and their carers and poses one of the major challenges to medical research.

Автор: Ken S. Kosik; Dennis J. Selkoe
Название: Alzheimer`s Disease: Lessons from Cell Biology
ISBN: 3642794254 ISBN-13(EAN): 9783642794254
Издательство: Springer
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Цена: 139310.00 T
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Описание: Like the unflinching gaze of Captain Ahab walking the deck of the Pequod, Alzheimer researchers have had their sights fixed firmly on the disease for many years. Perhaps for most of the years since the first descriptions of the disease in 1907, the science of Alzheimer`s disease was descriptive, and lay in the province of pathologists.

Автор: George Perry
Название: Alterations in the Neuronal Cytoskeleton in Alzheimer Disease
ISBN: 1461289203 ISBN-13(EAN): 9781461289203
Издательство: Springer
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Цена: 93160.00 T
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Описание: Although there is a general consensus that these abnormal filaments do contain cytoskeletal elements, much debate remains regarding which cytoskeletal elements are incorporated and whether the cytoskeletal rearrangement is primary or secondary to other cellular changes.