Apolipoprotein E and Alzheimer`s Disease, A.D. Roses; K.H. Weisgraber; Y. Christen
Автор: Rudolph Название: Alzheimer`s Disease ISBN: 1439827087 ISBN-13(EAN): 9781439827086 Издательство: Taylor&Francis Рейтинг: Цена: 114330.00 T Наличие на складе: Есть Описание:
In recent years, a tremendous amount of effort has been focused on better understanding the fundamentals of Alzheimer's disease (AD) to facilitate early and accurate diagnosis and appropriately targeted therapeutic treatments. Alzheimer's Disease: Targets for New Clinical, Diagnostic, and Therapeutic Strategies provides a detailed synopsis of the current state of the art of diagnostics and therapeutics and identifies emerging technologies and molecules that show promise in the management and treatment of AD.
With contributions from experts drawn from academia, clinical practice, and the biotechnology and pharmaceutical industries, the book explores:
The basis of AD and the role of Aβ oligomers in development of disease
Existing and emerging in vitro biomarker-based methodologies for the diagnosis of AD, focusing on genetic, biochemical, and conformational strategies
In vivo imaging diagnostic approaches
Evolving diagnostic criteria, health regulatory guidelines, biomarkers in clinical trials, and available and emerging therapies
Recent progress in small-molecule disease-modifier drug discovery efforts for AD, specifically in the areas of Aβ, tau, and emerging neuroprotective/neurorepair approaches
How a case study of AD raises issues regarding clinical and pathologic criteria, risk factors, and the amyloid hypothesis
The molecular conformational factors that govern the pathogenicity of aggregating proteins, and how these factors could represent new targets for disease-modifying therapies
The latest epidemiological, pathological, biochemical, and behavioral studies that may shed some light on the risk of developing AD and similar dementias after traumatic brain injury
Examining current hypotheses and suggesting possible new approaches to therapeutic clinical applications, this volume paves the way for a robust pipeline of therapeutics to combat not only AD, but a whole host of other neurodegenerative diseases.
Автор: Kurt A. Jellinger; Gernot Ladurner; Manfred Windis Название: New Trends in the Diagnosis and Therapy of Alzheimer`s Disease ISBN: 3211826203 ISBN-13(EAN): 9783211826201 Издательство: Springer Рейтинг: Цена: 113190.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Based on the 2nd International Symposium on EBEWE Research Initiative held in Salzburg, Austria, 1993, this book is a review of the current knowledge of morphology, diagnostic clinical and imaging techniques, and outcome variables and possibilities of therapy of AD and other neurodisorders.
Автор: G.M. Anantharamaiah; Dennis Goldberg Название: Apolipoprotein Mimetics in the Management of Human Disease ISBN: 3319362992 ISBN-13(EAN): 9783319362991 Издательство: Springer Рейтинг: Цена: 121110.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
This comprehensive book provides not only the stages in the development of this unique and specialized field but also updates on the current state of research and development of apolipoprotein mimetics as therapeutic modalities for various lipid-mediated disorders. The book consists of 11 chapters all written by leading scientists from well-reputed laboratories in the USA. After an introduction by Dr. Godfrey Getz, Professor of Medicine at the University of Chicago and the Associate Editor of the Journal Lipid Research, the book presents a narration of how a theory can lead to the discovery of treatment modalities to several devastating diseases such as diabetes, Alzheimer's disease, arthritis; asthma; atherosclerosis, chronic rejection of transplanted hearts and cancer.
Present therapies for most of these diseases are not adequate. Using the models of two long anti-atherogenic and anti-inflammatory proteins (apolipoprotein A-I and apolipoprotein E with 243 and 299 amino acids, respectively) short mimetic peptides of 18 to 28 amino acid residues in length, which can be produced either synthetically or genetically in edible fruits and vegetables, have been shown to exert profound biological effects in a large number of animal models of diseases.
The book also presents novel ideas, highly unexpected mechanisms of action in animal models and even in initial clinical studies in humans, which can lead to additional improvements in basic and clinical research in biological science. All the chapters are written by experts in their respective fields who have contributed immensely to the literature. This is the first compendium of this growing field presented in the form of a book.
Автор: C. R. Sirtori; A. V. Nichols; G. Franceschini Название: Human Apolipoprotein Mutants ISBN: 1461594766 ISBN-13(EAN): 9781461594765 Издательство: Springer Рейтинг: Цена: 46570.00 T Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Cesare Sirtori Название: Human Apolipoprotein Mutants 2 ISBN: 1461595517 ISBN-13(EAN): 9781461595519 Издательство: Springer Рейтинг: Цена: 46570.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The pleasant community of Limone suI Garda provided outstanding hospitality for a second NATO ARW dealing with apolipoprotein variants, which are natures clues for the discovery of the physiological roles of apolipoproteins in lipoprotein metabolism in normal subjects and patients with specific dyslipoproteinemias.
Автор: Cesare R. Sirtori; Guido Franceschini; Bryan H.Jr. Название: Human Apolipoprotein Mutants III ISBN: 364284636X ISBN-13(EAN): 9783642846366 Издательство: Springer Рейтинг: Цена: 121110.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Proceedings of the NATO Advanced Research Workshop on Human Apolipoprotein Mutants III. Apolipoproteins in the Diagnosis and Treatment of Disease, held at Limone sul Garda, Italy, April 5-8, 1992
Автор: Claude L. Malmendier; Petar Alaupovic Название: Eicosanoids, Apolipoproteins, Lipoprotein Particles, and Atherosclerosis ISBN: 1461280559 ISBN-13(EAN): 9781461280552 Издательство: Springer Рейтинг: Цена: 81050.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Plasma lipoproteins constitute a unique macromolecular system of lipid-protein complexes responsible for the transport of lipids from their sites of origin to their sites of utilization either as metabolic fuel or as structural components of cell membranes.
Автор: Maryvonne Rosseneu; Kurt Widhalm; Jochen Jarausch Название: Apolipoproteins in Lipid Disorders ISBN: 3211822739 ISBN-13(EAN): 9783211822739 Издательство: Springer Рейтинг: Цена: 81050.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This study describes the applications of the quantification of the plasma apo AI and B proteins, which are used in the identification and follow-up of patients at risk of developing cardiovascular disease.
Автор: Taher Zandi; Richard J. Ham Название: New Directions in Understanding Dementia and Alzheimer`s Disease ISBN: 1461279178 ISBN-13(EAN): 9781461279174 Издательство: Springer Рейтинг: Цена: 81050.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Proceedings of a conference held in Plattsburgh, New York, May 25--26, 1989
Автор: Stanley I. Rapoport; Henri Petit; Didier Leys Название: Imaging, Cerebral Topography and Alzheimer`s Disease ISBN: 3642756921 ISBN-13(EAN): 9783642756924 Издательство: Springer Рейтинг: Цена: 121110.00 T Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Joseph Rogers Название: Neuroinflammatory Mechanisms in Alzheimer`s Disease ISBN: 3034895291 ISBN-13(EAN): 9783034895293 Издательство: Springer Рейтинг: Цена: 46570.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Research into inflammatory mechanisms that may cause damage to the Alzheimer`s disease (AD) brain has now been ongoing for nearly two decades.
Автор: Bradley T. Hyman; Jean-Francois Demonet Название: The Living Brain and Alzheimer`s Disease ISBN: 3642639275 ISBN-13(EAN): 9783642639272 Издательство: Springer Рейтинг: Цена: 113190.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: From large cross-sectional studies of autopsy material, it seems as if a time course of Alzheimer`s Disease, at least on average, can be mapped out: a pattern of hierarchical vulnerability for neuronal loss and neurofibrillary tangles beginning in medial temporal lobe structures proceeding through association areas.
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