MHC + X, Pavol Ivanyi

Автор: Stephen H. Powis; Robert W. Vaughan
Название: MHC Protocols
ISBN: 1489938206 ISBN-13(EAN): 9781489938206
Издательство: Springer
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Цена: 121890.00 T
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Описание: The extreme genetic variation in HLA genes is believed to have been driven by the evolutionary response to infectious agents, but relatively few studies have analyzed associations between HLA genetic variation and infectious disease, which has been difficult to demonstrate.

Автор: Igor K. Egorov; Chella S. David
Название: Transgenic Mice and Mutants in MHC Research
ISBN: 3642754449 ISBN-13(EAN): 9783642754449
Издательство: Springer
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Цена: 102480.00 T
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Описание: This volume contains papers presented at the international conference on "Transgenic Mice and Mutants in MHC Research," held in Bar Harbor, Maine, in June, 1989. The meeting brought together eighty researchers working in the field. While mouse H-2 mutants have been known for many years their studies continue to contribute a great deal to our understanding of structure/function relationships and evolution of MHC molecules. Recently a new direction of research has emerged on regulation, expression and function of MHC genes using transgenic animals carrying exogenous MHC genes from the same or other species or engineered MHC genes. With the introduction of transgenic mice more specific questions about the various functions of MHC genes can be answered as, for example, the role of soluble and membrane-bound MHC molecules in self tolerance and elimination of specific T cell clones, recognition of human MHC antigens by the mouse immune system, the role of individual human MHC genes in disease susceptibility. New approaches for evaluation of the role of MHC linked and unlinked genes in susceptibility of mice to malignant tumors and their metastases have been also reported. Our purpose has been to provide a forum for discussion of these new developments. Many questions remain to be answered but the necessary tools have become available. We thank the contributors and hope that the readers will benefit from this Pro- ceedings. We wish to acknowledge the financial sponsorship for the meeting by The Pew Charitable Trust and Howard Hughes Medical Institute.

Автор: Antoine Blancher; Jan Klein; Wladyslaw W. Socha
Название: Molecular Biology and Evolution of Blood Group and MHC Antigens in Primates
ISBN: 3642638430 ISBN-13(EAN): 9783642638435
Издательство: Springer
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Цена: 113190.00 T
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Описание: Zoologists have categorized primates into a single order, and no one doubts today that they share a common ancestry. Humans and Old and New World non- human primate species, from the lemurs of Madagascar to the African anthro- poid apes, represent diverging branches of an evolutionary common trunk.