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Nitrates and Nitrate Tolerance in Angina Pectoris, M. Kaltenbach; G. Kober


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Автор: M. Kaltenbach; G. Kober
Название:  Nitrates and Nitrate Tolerance in Angina Pectoris
ISBN: 9783642853258
Издательство: Springer
Классификация:
ISBN-10: 3642853250
Обложка/Формат: Paperback
Страницы: 172
Вес: 0.30 кг.
Дата издания: 21.12.2011
Язык: English
Размер: 244 x 170 x 10
Основная тема: Medicine & Public Health
Ссылка на Издательство: Link
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Поставляется из: Германии
Описание: Although nitroglycerin is one of the oldest drugs in cardiology the problem of tolerance is a scientific challenge of today. The proceedings of this symposium highlight the most re- cent questions related to this topic. Apparently, partial tolerance, or rather partial decrease in sensitivity, can arise during nitrate therapy. Probably this is the consequence of a partial readjustment of the vascular system. This readjustment refers particularly to the arterial system, i.e., to the hypoten- sive effect of nitrates in the standing position. A similar effect on the venous side is not present. On the other hand, the results assembled in this volume confirm the experience of many decades that long-term antianginal therapy with nitrates remains effective even when high doses are applied. Thus partial tolerance which also occurs after other vasodilators such as prazosin, does not imply tolerance against antianginal effectiveness. From the information available to- day it is reasonable to treat patients with angina pectoris acutely as well as chronically with nitrates in individually adjusted doses. Frankfurt, November 1982 M. Kaltenbach v Contents Foreword................................................................ V Session 1-Pharmacology Tolerance from the Pharmacokinetic and Pharmacodynamic Viewpoints N. Rietbrock, A. Lassmann, B. G. Woodcock ................................ 3 Does Tolerance Develop During Long-Acting Nitrate Therapy? A Critical Review J. Abrams ............................................................... 13 Pharmacokinetics of Isosorbide Dinitrate During Tolerance Development Ho-Leung Fung .......................................................... 25 Discussion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 29 . . . . . . . . . . . . . . . . . . . Session II - Hemodynamics Lack of Tolerance Development to the Hemodynamic Effects of Nitrates in Patients with Chronic Congestive Heart Failure Joseph A. Franciosa ...................................................... 35 Discussion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 41 . . . . . . . . . . . . . . . . . . . .

Beta-Blockers in Hypertension and Angina Pectoris

Автор: T.J. Cleophas
Название: Beta-Blockers in Hypertension and Angina Pectoris
ISBN: 0792335163 ISBN-13(EAN): 9780792335160
Издательство: Springer
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Цена: 71730.00 T
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Описание: Although there are mass action effects common to all of beta-adrenergic block- ing agents, these agents differ in their effects on the RAS system, beta blockade, norepinephrine release, CNS effects, peripheral vas- cular resistance, inotrophic effects, vasomotor effects, and effects on plasma volume.

Advances in Nitrate Therapy

Автор: Adam Schneeweiss; Marija Weiss
Название: Advances in Nitrate Therapy
ISBN: 3642758363 ISBN-13(EAN): 9783642758362
Издательство: Springer
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Цена: 93160.00 T
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Описание: Nitrates have been for many years the cornerstone of cardiovascular therapy for various indications. The primarily used nitrates in clinical practice are nitroglycerin and the com- plex organic nitrates, mainly isosorbide dinitrate.

Nitrate Contamination

Автор: Istvan Bogardi; Robert D. Kuzelka; Wilma G. Enneng
Название: Nitrate Contamination
ISBN: 3642760422 ISBN-13(EAN): 9783642760426
Издательство: Springer
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Цена: 156720.00 T
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Описание: Proceedings of the NATO Advanced Research Workshop on Nitrate Contamination: Exposure, Consequences, and Control held at Lincoln, Nebraska (USA) from September 9-14, 1990

Nitrates Updated

Автор: Udho Thadani; Lionel H. Opie
Название: Nitrates Updated
ISBN: 1461284341 ISBN-13(EAN): 9781461284345
Издательство: Springer
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Цена: 194730.00 T
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Описание: Nitrates remain among the most commonly used therapeutic agents in cardiology. That they can re- lieve pain in angina pectoris has been known at least since 1867, when Lauder Brunton described their clinical use. Now, almost 130 years later, we are constantly learning more about their optimal use in anginal syndromes. For example, there is no doubt that nitrate tolerance occurs, but equally no doubt that certain drug dosages help to attenuate such toler- ance. Thus, our understanding of nitrate tolerance has been taken further by the advent of new nitrate preparations and by studies at a basic science level. The current intense interest in nitrates has been rekindled by the growing emphasis on the role of the endothelium in the production of nitric oxide, a basic cardiovascular regulator. If nitric oxide is vasodilator and protects the vascular endothelium, then nitrates should also have similar properties. Hence this book starts off with the role of the endothelium and ni- trates in vasodilation. Next, the mechanisms of ac- tion of nitrates are considered with emphasis on the role of cyclic GMP. The chief limitation to the use of nitrates lies in nitrate tolerance. After carefully looking at all the evidence, the authors of the third chapter conclude that the mechanism is likely to be multifactorial. The mechanism responsible for the tolerance still remains unknown. In vitro tolerance may be due to enhanced production of vascular superoxide 1].

Angina Pectoris with Normal Coronary Arteries: Syndrome X

Автор: Juan Carlos Kaski
Название: Angina Pectoris with Normal Coronary Arteries: Syndrome X
ISBN: 0792326512 ISBN-13(EAN): 9780792326519
Издательство: Springer
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Цена: 269260.00 T
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Описание: Angina pectoris with normal coronary arteriograms is a common entity which has puzzled cardiologists almost since the advent of coronary arteriography. Indeed, results of investigations are controversial and speculation still prevails regarding the nature of the so called `Syndrome X`. This title examines various important aspects of Syndrome X.

Drug Evaluation in Angina Pectoris

Автор: Gianluigi Ardissino; Lionel H. Opie; Stefano Savon
Название: Drug Evaluation in Angina Pectoris
ISBN: 1461361273 ISBN-13(EAN): 9781461361275
Издательство: Springer
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Цена: 139750.00 T
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Описание: Although there are many books on angina, few are devoted to the important problem of how to evaluate drug efficacy in angina pectoris.

Pharmacological Treatment of Chronic Stable Angina Pectoris

Автор: Pablo Avanzas; Juan Carlos Kaski
Название: Pharmacological Treatment of Chronic Stable Angina Pectoris
ISBN: 3319173316 ISBN-13(EAN): 9783319173313
Издательство: Springer
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Цена: 46570.00 T
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Описание: This book is intended for general cardiologists and other physicians involved in the care of patients with chronic stable angina (CSA). The management of these patients encompasses lifestyle modification, control of coronary artery disease risk factors, evidence-based pharmacological therapy and patient education.

Drug Evaluation in Angina Pectoris

Автор: Gianluigi Ardissino; Lionel H. Opie; Stefano Savon
Название: Drug Evaluation in Angina Pectoris
ISBN: 0792328973 ISBN-13(EAN): 9780792328971
Издательство: Springer
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Цена: 204040.00 T
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Описание: Intends to review the methodological aspects of drug evaluation in stable and unstable angina pectoris. This book provides a background for studies aimed at assessing the ability of medical treatment to improve prognosis. It is suitable for cardiologists, pharmacologists, and advanced students of cardiology.

Angina Pectoris with Normal Coronary Arteries: Syndrome X

Автор: Juan Carlos Kaski
Название: Angina Pectoris with Normal Coronary Arteries: Syndrome X
ISBN: 1461361117 ISBN-13(EAN): 9781461361114
Издательство: Springer
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Цена: 186330.00 T
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Описание: Angina pectoris with normal coronary arteriograms is a common entity which has puzzled cardiologists almost since the advent of coronary arteriography. Despite major advances in the understanding of the pathophysiology of angina in recent years and a multitude of studies on the subject, the cause and mechanisms underlying the syndrome of angina with normal coronary arteries remain unknown. Indeed, results of investigations are controversial and speculation still prevails regarding the nature of the so called Syndrome X'.
Almost every important aspect of Syndrome X has been tackled in the book and the reader is exposed not only to the cardiologists' opinion, but also to the authoritative views of the gastroenterologists, gynaecologists and psychiatrists, extremely well represented in this monograph. The book deals with cardiologists' Syndrome X' and not the metabolic entity termed Syndrome X'. The possible connection between the two, however, is discussed.
Angina with Normal Coronary Arteries: Syndrome X contributes to the understanding of Syndrome X and helps clinicians manage their Syndrome X-patients better and investigators to open new avenues for research.

Organic Nitrates

Автор: P. Needleman
Название: Organic Nitrates
ISBN: 3642660266 ISBN-13(EAN): 9783642660269
Издательство: Springer
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Цена: 121110.00 T
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Описание: Nitroglycerin and other organic nitrates have been used for over a century in the treatment of angina pectoris. We now have considerably more insight into the pathways of degradation of organic nitrates and the relationship of the metabolic processes to the biological action of these agents.

The Nitrate King

Автор: W. Edmundson
Название: The Nitrate King
ISBN: 1349294756 ISBN-13(EAN): 9781349294756
Издательство: Springer
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Цена: 60550.00 T
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Описание: William Edmundson examines the spectacular life story of `Colonel` John Thomas North, also known as `The Nitrate King,` a mechanic in Leeds who became one of the best-known and richest men of his time. Forgotten in Britain and vilified in Chile and Peru, this is the first biography of a controversial but compelling figure.

Nitrite and Nitrate in Human Health and Disease

Автор: Nathan S. Bryan; Joseph Loscalzo
Название: Nitrite and Nitrate in Human Health and Disease
ISBN: 3319461877 ISBN-13(EAN): 9783319461878
Издательство: Springer
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Цена: 111790.00 T
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Описание: They follow a strict chapter format which includes keywords, key points, a conclusion highlighting major findings, and extensive references.The second edition contains new chapters on nitrite and nitrate in age medicine, nitrite and nitrate as a treatment for hypertension, and nitrite and nitrate in exercise performance.


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