Nitrates Updated, Udho Thadani; Lionel H. Opie

Автор: M. Kaltenbach; G. Kober
Название: Nitrates and Nitrate Tolerance in Angina Pectoris
ISBN: 3642853250 ISBN-13(EAN): 9783642853258
Издательство: Springer
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Описание: Although nitroglycerin is one of the oldest drugs in cardiology the problem of tolerance is a scientific challenge of today. The proceedings of this symposium highlight the most re- cent questions related to this topic. Apparently, partial tolerance, or rather partial decrease in sensitivity, can arise during nitrate therapy. Probably this is the consequence of a partial readjustment of the vascular system. This readjustment refers particularly to the arterial system, i.e., to the hypoten- sive effect of nitrates in the standing position. A similar effect on the venous side is not present. On the other hand, the results assembled in this volume confirm the experience of many decades that long-term antianginal therapy with nitrates remains effective even when high doses are applied. Thus partial tolerance which also occurs after other vasodilators such as prazosin, does not imply tolerance against antianginal effectiveness. From the information available to- day it is reasonable to treat patients with angina pectoris acutely as well as chronically with nitrates in individually adjusted doses. Frankfurt, November 1982 M. Kaltenbach v Contents Foreword................................................................ V Session 1-Pharmacology Tolerance from the Pharmacokinetic and Pharmacodynamic Viewpoints N. Rietbrock, A. Lassmann, B. G. Woodcock ................................ 3 Does Tolerance Develop During Long-Acting Nitrate Therapy? A Critical Review J. Abrams ............................................................... 13 Pharmacokinetics of Isosorbide Dinitrate During Tolerance Development Ho-Leung Fung .......................................................... 25 Discussion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 29 . . . . . . . . . . . . . . . . . . . Session II - Hemodynamics Lack of Tolerance Development to the Hemodynamic Effects of Nitrates in Patients with Chronic Congestive Heart Failure Joseph A. Franciosa ...................................................... 35 Discussion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 41 . . . . . . . . . . . . . . . . . . . .

Автор: P. Lichtlen; H.-J. Engel; A. Schrey; H.J.C. Swan
Название: Nitrates III
ISBN: 3642680879 ISBN-13(EAN): 9783642680878
Издательство: Springer
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Описание: Pharmacological and clinical research on nitrates continues to be of growing interest in many centers. Although most investigators agree that intracellular sequestration of calcium is probably the main mechanism by which nitrates lead to the reduction of vascular smooth muscle tone, the exact site of their action still remains undefined.

Автор: Udho Thadani; Lionel H. Opie
Название: Nitrates Updated
ISBN: 0792334663 ISBN-13(EAN): 9780792334668
Издательство: Springer
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Описание: This review of current research in the use of nitrates as cardiovascular drugs covers such topics as: mechanisms of action of nitrates; short and long-acting oral nitrates for stable angina pectoris; nitrates in myocardial infarction; and nitrates in congestive heart failure.

Автор: W. Edmundson
Название: The Nitrate King
ISBN: 1349294756 ISBN-13(EAN): 9781349294756
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Описание: William Edmundson examines the spectacular life story of `Colonel` John Thomas North, also known as `The Nitrate King,` a mechanic in Leeds who became one of the best-known and richest men of his time. Forgotten in Britain and vilified in Chile and Peru, this is the first biography of a controversial but compelling figure.

Автор: Istvan Bogardi; Robert D. Kuzelka; Wilma G. Enneng
Название: Nitrate Contamination
ISBN: 3642760422 ISBN-13(EAN): 9783642760426
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Цена: 156720.00 T
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Описание: Proceedings of the NATO Advanced Research Workshop on Nitrate Contamination: Exposure, Consequences, and Control held at Lincoln, Nebraska (USA) from September 9-14, 1990

Автор: AnnMarie Kocher; Joseph Loscalzo
Название: Nitrite and Nitrate in Human Health and Disease
ISBN: 1617797332 ISBN-13(EAN): 9781617797330
Издательство: Springer
Цена: 213360.00 T
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Описание: 1. Introduction - Co-Editors: Nathan S. Bryan, Ph.D., Joseph Loscalzo, M.D, Ph.D. 2. From Atmospheric Nitrogen to Bioactive Nitrogen Oxides - Mark Gilchrist, Ph.D., Nigel Benjamin, M.D. 3. The Nitrate-Nitrite-Nitric Oxide Pathway in Mammals - Jon Lundberg, M.D., Ph.D. Eddie Weitzberg M.D., Sruti Shiva, Ph.D., Mark Gladwin M.D. 4. Sources of Exposure to Nitrogen Oxides - Andrew Milkowski, Ph.D. Section 2: FOOD AND ENVIRONMENTAL EXPOSURES TO NITRITE AND NITRATE 5. History of Nitrite and Nitrate in Foods - Jimmy Keeton, Ph.D. 6. Nutritional Epidemiology of Nitrogen Oxides: What do the Numbers Mean? - Martin LaJous, M.D., Walter Willet, M.D, MPH. 7. Nutritional Impact on the Nitric Oxide Pathway - Wing Tak Wong, Ph.D., John Cooke, M.D., Ph.D. 8. Dietary Flavonoids as Modulators of NO bioavailability in Acute and Chronic Cardiovascular Disease - Matthias Totzeck, M.D., Malte Kelm, M.D., Ph.D., Tienush Rassaf, M.D., Ph.D. 9. Nitrite and Nitrate in Human Breast Milk: Implications for Development - Pamela D. Berens, M.D., Nathan S. Bryan, Ph.D. 10. Regulation of Dietary Nitrate and Nitrite: Balancing Essential Physiological Roles with Potential Health Risks - Norman Hord, Ph.D., R.D. Section 3: NITRITE AND NITRATE IN THERAPEUTICS AND DISEASE 11. Nitric Oxide Signaling in Health and Disease - Nathan S. Bryan, Ph.D., Jack Lancaster, Ph.D. 12. Inhaled Nitric Oxide - Kenneth Bloch, M.D., Andrea Steinbicker, M.D., Lisa Lohmeyer, Rajeev Malhotra, M.D. 13. Pharmacology of Nitrovasodilators - Nathaniel Page, Pharm D., Ho-Leung Fung, Ph.D. 14. Nitrite and Nitrate in Ischemia-Reperfusion Injury - Madhav Lavu, M.D., Susheel Gundewar, M.D., David Lefer, Ph.D. 15. The Nitrate-Nitrite-Nitric Oxide Pathway in Traditional Herbal Medicine for Heart Disease - Yong Jian Geng, M.D., Ph.D. 16. Nitrite and Nitrate in Cancer - David M. Klurfeld, Ph.D. 17. Looking Forward - Co-Editors: Nathan S. Bryan, Ph.D., and Joseph Loscalzo, M.D., Ph.D.

Автор: P. Needleman
Название: Organic Nitrates
ISBN: 3642660266 ISBN-13(EAN): 9783642660269
Издательство: Springer
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Описание: Nitroglycerin and other organic nitrates have been used for over a century in the treatment of angina pectoris. We now have considerably more insight into the pathways of degradation of organic nitrates and the relationship of the metabolic processes to the biological action of these agents.

Автор: Adam Schneeweiss; Marija Weiss
Название: Advances in Nitrate Therapy
ISBN: 3642758363 ISBN-13(EAN): 9783642758362
Издательство: Springer
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Описание: Nitrates have been for many years the cornerstone of cardiovascular therapy for various indications. The primarily used nitrates in clinical practice are nitroglycerin and the com- plex organic nitrates, mainly isosorbide dinitrate.

Автор: T. Breimer
Название: Environmental Factors and Cultural Measures Affecting The Nitrate Content in Spinach
ISBN: 9024730538 ISBN-13(EAN): 9789024730537
Издательство: Springer
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Описание: Contents Preface / v Abstract / 1 List of ab breviations / 2 Introduction / 3 2 Literature / 6 2. 1 Nitrogen transformations in soil / 7 2. 2 Nitrate uptake / 7 Nitrate reduction in plants / 7 2. 4 Nitrate contents in plants / 8 2. 5 Cultural measures / 9 2. 1 Nitrogen dressing / 9 2. 1 Nitrogen amount / 9 2.

Автор: Nathan S. Bryan; Joseph Loscalzo
Название: Nitrite and Nitrate in Human Health and Disease
ISBN: 3319461877 ISBN-13(EAN): 9783319461878
Издательство: Springer
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Описание: They follow a strict chapter format which includes keywords, key points, a conclusion highlighting major findings, and extensive references.The second edition contains new chapters on nitrite and nitrate in age medicine, nitrite and nitrate as a treatment for hypertension, and nitrite and nitrate in exercise performance.