Biochemistry of Arachidonic Acid Metabolism, William E.M. Lands

Автор: William E.M. Lands
Название: Biochemistry of Arachidonic Acid Metabolism
ISBN: 0898387175 ISBN-13(EAN): 9780898387179
Издательство: Springer
Рейтинг:
Цена: 231990.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Prostaglandins, Leukotrienes, and Cancer is a multi-volume series that will focus on an emerging area of cancer research. In 1968, R.H. Williams first reported that elevated prostaglandin levels are present in human medullary car- cinoma. Since that time, the concept that arachidonic acid metabolites may be in- volved in cancer has expanded to include every aspect of the disease from cell transformation through metastasis. Prostaglandins and leukotrienes are generic terms used to describe a family of bioactive lipids produced from unsaturated fatty acids (principally from arachidonic acid) via the cyclooxygenase and lipoxygenase pathways, respec- tively. Cyclooxygenase products consist of diverse products such as prosta- glandin E, (POE, ), prostacyclin (POI2) and thromboxane A2 (TXA2), whereas lipoxygenase products consist of hydroperoxy fatty acids and mono-, di- and tri-hydroxy acids including leukotrienes. The precursor fatty acids for the cyclooxygenase and lip oxygenase pathways are present in cellular phospholipids. This finding established an important control point in their biosynthesis-the release of substrate. This occurs in response to numerous stimuli that act at the cell surface. Dr. Bengt Samuelsson's extensive study of the metabolism of pros- taglandins indicated that they are rapidly inactivated on a single pass through pulmonary circulation. Thus, they cannot act as circulating hormones and appear to be made on demand in or in the vicinity of target tissues leading to the concept that prostaglandins are local hormones or autocoids.

Автор: Lawrence J. Marnett
Название: Arachidonic Acid Metabolism and Tumor Initiation
ISBN: 146129634X ISBN-13(EAN): 9781461296348
Издательство: Springer
Рейтинг:
Цена: 163040.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Prostaglandins, Leukotrienes, and Cancer is a multi-volume series that will focus on an emerging area of cancer research. In 1968, R.H. Williams first reported that elevated prostaglandin levels are present in human medullary car- cinoma. Since that time, the concept that arachidonic acid metabolites may be in- volved in cancer has expanded to include every aspect of the disease from cell transformation through metastasis. Prostaglandins and leukotrienes are generic terms used to describe a family of bioactive lipids produced from unsaturated fatty acids (principally from arachidonic acid) via the cyclooxygenase and lipoxygenase pathways, respec- tively. Cyclooxygenase products consist of diverse products such as prosta- glandin E2 (POE ), prostacyclin (POI ) and thromboxane A2 (TXA ), whereas 2 2 2 lipoxygenase products consist of hydroperoxy fatty acids and mono-, di- and tri-hydroxy acids including leukotrienes. The precursor fatty acids for the cyclooxygenase and lipoxygenase pathways are present in cellular phospholipids. This finding established an important control point in their biosynthesis-the release of substrate. This occurs in response to numerous stimuli that act at the cell surface. Dr. Bengl Samuelsson's extensive study of the metabolism of pros- taglandins indicated that they are rapidly inactivated on a single pass through pulmonary circulation. Thus, they cannot act as circulating hormones and appear to be made on demand in or in the vicinity of target tissues leading to the concept that prostaglandins are local hormones or autocoids.

Автор: Susan M. Fischer; Thomas J. Slaga
Название: Arachidonic Acid Metabolism and Tumor Promotion
ISBN: 1461296315 ISBN-13(EAN): 9781461296317
Издательство: Springer
Рейтинг:
Цена: 186340.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Prostaglandins, Leukotrienes, and Cancer is a multi-volume series that will focus on an emerging area of cancer research. In 1968, R.H. Williams first reported that elevated prostaglandin levels are present in human medullary car- cinoma. Since that time, the concept that arachidonic acid metabolites may be in- volved in cancer has expanded to include every aspect of the disease from cell transformation through metastasis. Prostaglandins and leukotrienes are generic terms used to describe a family of bioactive lipids produced from unsaturated fatty acids (principally from and lipoxygenase pathways, respec- arachidonic acid) via the cyclooxygenase tively. Cyclooxygenase products consist of diverse products such as prosta- glandin E2 (POE), prostacyclin (POI) and thromboxane A2 (TXA), whereas 2 2 2 lipoxygenase products consist of hydroperoxy fatty acids and mono-, di- and tri-hydroxy acids including leukotrienes. The precursor fatty acids for the cyclooxygenase and lipoxygenase pathways are present in cellular phospholipids. This finding established an important control point in their biosynthesis-the release of substrate. This occurs in response to numerous stimuli that act at the cell surface. Dr. Bengt Samuelsson's extensive study of the metabolism of pros- taglandins indicated that they are rapidly inactivated on a single pass through pulmonary circulation. Thus, they cannot act as circulating hormones and appear to be made on demand in or in the vicinity of target tissues leading to the concept that prostaglandins are local hormones or autocoids.

Автор: Lawrence J. Marnett
Название: Arachidonic Acid Metabolism and Tumor Initiation
ISBN: 0898387299 ISBN-13(EAN): 9780898387292
Издательство: Springer
Рейтинг:
Цена: 186340.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Prostaglandins, Leukotrienes, and Cancer is a multi-volume series that will focus on an emerging area of cancer research. In 1968, R.H. Williams first reported that elevated prostaglandin levels are present in human medullary car- cinoma. Since that time, the concept that arachidonic acid metabolites may be in- volved in cancer has expanded to include every aspect of the disease from cell transformation through metastasis. Prostaglandins and leukotrienes are generic terms used to describe a family of bioactive lipids produced from unsaturated fatty acids (principally from arachidonic acid) via the cyclooxygenase and lipoxygenase pathways, respec- tively. Cyclooxygenase products consist of diverse products such as prosta- glandin E2 (POE ), prostacyclin (POI ) and thromboxane A2 (TXA ), whereas 2 2 2 lipoxygenase products consist of hydroperoxy fatty acids and mono-, di- and tri-hydroxy acids including leukotrienes. The precursor fatty acids for the cyclooxygenase and lipoxygenase pathways are present in cellular phospholipids. This finding established an important control point in their biosynthesis-the release of substrate. This occurs in response to numerous stimuli that act at the cell surface. Dr. Bengl Samuelsson's extensive study of the metabolism of pros- taglandins indicated that they are rapidly inactivated on a single pass through pulmonary circulation. Thus, they cannot act as circulating hormones and appear to be made on demand in or in the vicinity of target tissues leading to the concept that prostaglandins are local hormones or autocoids.

Автор: Susan M. Fischer; Thomas J. Slaga
Название: Arachidonic Acid Metabolism and Tumor Promotion
ISBN: 0898387248 ISBN-13(EAN): 9780898387247
Издательство: Springer
Рейтинг:
Цена: 204040.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Prostaglandins, Leukotrienes, and Cancer is a multi-volume series that will focus on an emerging area of cancer research. In 1968, R.H. Williams first reported that elevated prostaglandin levels are present in human medullary car- cinoma. Since that time, the concept that arachidonic acid metabolites may be in- volved in cancer has expanded to include every aspect of the disease from cell transformation through metastasis. Prostaglandins and leukotrienes are generic terms used to describe a family of bioactive lipids produced from unsaturated fatty acids (principally from and lipoxygenase pathways, respec- arachidonic acid) via the cyclooxygenase tively. Cyclooxygenase products consist of diverse products such as prosta- glandin E2 (POE), prostacyclin (POI) and thromboxane A2 (TXA), whereas 2 2 2 lipoxygenase products consist of hydroperoxy fatty acids and mono-, di- and tri-hydroxy acids including leukotrienes. The precursor fatty acids for the cyclooxygenase and lipoxygenase pathways are present in cellular phospholipids. This finding established an important control point in their biosynthesis-the release of substrate. This occurs in response to numerous stimuli that act at the cell surface. Dr. Bengt Samuelsson's extensive study of the metabolism of pros- taglandins indicated that they are rapidly inactivated on a single pass through pulmonary circulation. Thus, they cannot act as circulating hormones and appear to be made on demand in or in the vicinity of target tissues leading to the concept that prostaglandins are local hormones or autocoids.

Автор: Daniele Piomelli
Название: Arachidonic Acid in Cell Signaling
ISBN: 366205809X ISBN-13(EAN): 9783662058091
Издательство: Springer
Рейтинг:
Цена: 95770.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book is about the arachidonic acid cascade, its biochemistry, its pharmacology, and its roles in signal transduction.

Автор: Anthony J. Sbarra
Название: Biochemistry and Metabolism
ISBN: 1461591368 ISBN-13(EAN): 9781461591368
Издательство: Springer
Рейтинг:
Цена: 113190.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This comprehensive treatise on the reticuloendothelial system is a project jointly shared by individual members of the Reticuloendothelial (RE) Society and bio- medical scientists in general who are interested in the intricate system of cells and molecular moieties derived from these cells which constitute the RES.

Автор: Bernard Testa
Название: Hydrolysis in Drug and Prodrug Metabolism: Chemistry, Biochemistry, and Enzymology
ISBN: 390639025X ISBN-13(EAN): 9783906390253
Издательство: Wiley
Рейтинг:
Цена: 158400.00 T
Наличие на складе: Невозможна поставка.
Описание: In this volume, Professor Bernard Testa and Dr Joachim Mayer discuss the molecular and biochemical aspects of metabolic reactions of hydrolysis and hydration. While an encyclopaedic treatment is avoided, the covered topics include biochemicproperties of the enzymes/isozymes, drug-enzyme interactions, the various chemical reactions catalyzed by the enzyme(s), reaction mechanisms and catalytic cycles, regio- and stereoselectivities, structure-metabolism relationships, molecular aspects of toxication and detoxication, as well as enzyme inhibition. The classification of matters is based mainly on the types of target groups and compounds being transformed, with carefully selected examples illustrating the reactions under discussion. Such a treatment has heuristic value since it renders the reader capable of educated guesses on the metabolism of other or novel drugs.