Hydrolysis in Drug and Prodrug Metabolism: Chemistry, Biochemistry, and Enzymology, Bernard Testa

Название: Methods in Enzymology V 379
ISBN: 0121827836 ISBN-13(EAN): 9780121827830
Издательство: Elsevier Science
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Описание: This volume focuses on the cooperative binding aspects of energetics in biological macromolecules. Methodologies such as NMR, small-angle scattering techniques for analysis, calorimetric analysis, fluorescence quenching, and time resolved FRET measurements are discussed.

Название: Methods in Enzymology V 378
ISBN: 0121827828 ISBN-13(EAN): 9780121827823
Издательство: Elsevier Science
Цена: 132640.00 T
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Описание: Quinones are members of a class of aromatic compounds with two oxygen atoms bonded to the ring as carbonyl groups. This volume covers the role of quinines enzymes in cellular signalling and modulation of gene expression.

Название: Methods in Enzymology V 375
ISBN: 0121827798 ISBN-13(EAN): 9780121827793
Издательство: Elsevier Science
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Описание: DNA in the nucleus of plant and animal cells is stored in the form of chromatin. Chromatin and the Chromatin remodellng enzymes play an important role in gene transcription.

Название: Methods in Enzymology V 374
ISBN: 0121827771 ISBN-13(EAN): 9780121827779
Издательство: Elsevier Science
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Описание: Accurate molecular structures is vital for rational drug design and for structure based functional studies directed toward the development of effective therapeutic agents and drugs. Crystallography can reliably predict structure, both in terms of folding and atomic details of bonding.

Название: Methods in Enzymology V 364
ISBN: 0121822672 ISBN-13(EAN): 9780121822675
Издательство: Elsevier Science
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Описание: Nuclear Receptors are inducible transcription ftors that mediate complex effects on development, differentiation and homeostasis. They regulate the transcription of their target genes through binding to DNA sequences.

Название: Methods in Enzymology V 361
ISBN: 0121822648 ISBN-13(EAN): 9780121822644
Издательство: Elsevier Science
Цена: 132640.00 T
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Описание: This volume and its companion volume 360 introduce a new topic to the Methods in Enzymology series. They will cover, among other topics, imaging, screening, and diagnosis in biological systems. See key features for greater detail.

Название: Methods in Enzymology V 373
ISBN: 0121822761 ISBN-13(EAN): 9780121822767
Издательство: Elsevier Science
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Описание: Liposomes are cellular structures made up of lipid molecules. Important as a cellular model in the study of basic biology liposomes are also used in clinical applications such as drug delivery and virus studies.

Название: Methods in Enzymology V 371
ISBN: 0121822745 ISBN-13(EAN): 9780121822743
Издательство: Elsevier Science
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Описание: RNA polymerase is molecule important to gene transcription. Along with associated factors, RNA polymerase is part of the process in which RNA is transcribed to produce a protein.

Название: Methods in Enzymology V 370
ISBN: 0121822737 ISBN-13(EAN): 9780121822736
Издательство: Elsevier Science
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Описание: RNA polymerase is molecule important to gene transcription. Along with associated factors, RNA polymerase is part of the process in which RNA is transcribed to produce a protein.

Название: Methods in Enzymology V 369
ISBN: 0121822729 ISBN-13(EAN): 9780121822729
Издательство: Elsevier Science
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Описание: Combinatorial Chemistry encompasses both the design of compounds for specific pharmacological use and the screening of molecules in high throughput automated tests to find active agents with specific functions.

Название: Methods in Enzymology V 368
ISBN: 0121822710 ISBN-13(EAN): 9780121822712
Издательство: Elsevier Science
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Описание: Accurate molecular structures are vital for rational drug design and for structure-based functional studies directed toward the development of effective therapeutic agents and drugs. Crystallography can reliably predict structure, both in terms of folding and atomic details of bonding.

Автор: Vivekkumar K Redasani
Название: Prodrug Design
ISBN: 0128035196 ISBN-13(EAN): 9780128035191
Издательство: Elsevier Science
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Описание:

Prodrug Design: Perspectives, Approaches and Applications in Medicinal Chemistry provides a focused overview of this critical area of drug discovery, as that continuous process strives not only to discover new drug compounds but also to modify the existing ones. This valuable primer supports this mission of drug development and its goal of reducing undesired effects and improving therapeutic effectiveness of drug compounds. Providing a unique compilation of data, insightful case studies, and review of existing literature in the area, the book will promote innovation in medicinal and pharmaceutical chemistry research, exploring the limitations of existing drugs and their improvement. Prodrug Design reviews marketed compounds, the safety of promoieties, and a detailed classification of prodrugs organized by therapeutic area for easy reference.