Receptors and Recognition, P. CUATRECASAS AND M. F. GREAVES

Автор: Anton G. Kutikhin; Arseniy E. Yuzhalin
Название: Genomics of Pattern Recognition Receptors
ISBN: 3034806876 ISBN-13(EAN): 9783034806879
Издательство: Springer
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Цена: 139310.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book details the polymorphisms of genes encoding pattern recognition receptors (PRRs). Following a short description of the general role of PRRs in the immune system, coverage examines the structure and function of Toll-like and NOD-like receptors.

Автор: Rast
Название: Immune Receptors
ISBN: 1617791385 ISBN-13(EAN): 9781617791383
Издательство: Springer
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Цена: 135090.00 T
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Описание: Immunology has made significant progress in the past decade, driven forward by rapidly advancing technology and a renewed interest in the vast realm of innate immunity. The receptors that mediate these functions are at the front lines of both protective and regulative roles of the immune system.  In Immune Receptors: Methods and Protocols, expert researchers present a variety of experimental approaches to the characterization of immune receptors and the cell biology that mediates their functions.  These include imaging techniques that aim to understand receptor localization and trafficking, techniques to measure receptor-ligand interactions, strategies to identify novel ligands and methods to analyze downstream receptor signaling, as well as strategies for genomic and proteomic characterization of receptor repertoires. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective subjects, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Immune Receptors: Methods and Protocols offers technical descriptions and protocols that will be useful both to investigators who are interested in carrying out these procedures and to those who seek a deeper understanding of the bench science that lies behind the immunology literature.

Автор: Y. C. Lee
Название: Recognition of Carbohydrates in Biological Systems, Part A : Gene
ISBN: 0121822656 ISBN-13(EAN): 9780121822651
Издательство: Elsevier Science
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Цена: 167030.00 T
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Описание: Recognition of carbohydrates in biological systems has been gaining more and more attention in recent years. Although methodology for studying recognition has been developing, there is no volume that covs the wide area of methodology of carbohydrate recognition. This volume and its companion, Volume 363, present state-of-the-art methodologies, as well as the most recent biological observations in this area.

Автор: Alexander Sigalov
Название: Multichain Immune Recognition Receptor Signaling
ISBN: 1441918876 ISBN-13(EAN): 9781441918871
Издательство: Springer
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Цена: 213360.00 T
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Описание: This book shows how the structural similarity of MIRRs determines the general principles underlying MIRR-mediated transmembrane signaling mechanisms. In so doing, it provides the basis for existing and future therapeutic strategies targeting MIRRs.

Автор: Yogambigai Velmurugu
Название: Dynamics and Mechanism of DNA-Bending Proteins in Binding Site Recognition
ISBN: 3319451286 ISBN-13(EAN): 9783319451282
Издательство: Springer
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Цена: 111790.00 T
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Описание: Using a novel approach that combines high temporal resolution of the laser T-jump technique with unique sets of fluorescent probes, this study unveils previously unresolved DNA dynamics during search and recognition by an architectural DNA bending protein and two DNA damage recognition proteins. Many cellular processes involve special proteins that bind to specific DNA sites with high affinity. How these proteins recognize their sites while rapidly searching amidst ~3 billion nonspecific sites in genomic DNA remains an outstanding puzzle. Structural studies show that proteins severely deform DNA at specific sites and indicate that DNA deformability is a key factor in site-specific recognition. However, the dynamics of DNA deformations have been difficult to capture, thus obscuring our understanding of recognition mechanisms. The experiments presented in this thesis uncover, for the first time, rapid (~100-500 microseconds) DNA unwinding/bending attributed to nonspecific interrogation, prior to slower (~5-50 milliseconds) DNA kinking/bending/nucleotide-flipping during recognition. These results help illuminate how a searching protein interrogates DNA deformability and eventually “stumbles” upon its target site. Submillisecond interrogation may promote preferential stalling of the rapidly scanning protein at cognate sites, thus enabling site-recognition. Such multi-step search-interrogation-recognition processes through dynamic conformational changes may well be common to the recognition mechanisms for diverse DNA-binding proteins.

Автор: A.D. Buckingham; A.C. Legon; S.M. Roberts
Название: Principles of Molecular Recognition
ISBN: 9401049599 ISBN-13(EAN): 9789401049597
Издательство: Springer
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Цена: 93160.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The importance of molecular recognition in chemistry and biology is reflected in a recent upsurge in relevant research, promoted in particular by high-profile initiatives in this area in Europe, the USA and Japan.

Автор: Y. C. Lee
Название: Recognition of Carbohydrates in Biological Systems, Part B: Speci
ISBN: 0121822664 ISBN-13(EAN): 9780121822668
Издательство: Elsevier Science
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Цена: 151590.00 T
Наличие на складе: Поставка под заказ.
Описание: Recognition of carbohydrates in biological systems has been gaining more and more attention in recent years. Although methodology for studying recognition has been developing, there is no volume that covers the wide area of methodology of carbohydrate recognition. This volume and its companion, Volume 362, present state-of-the-art methodologies, as well as the most recent biological observations in this area.

Автор: Anton G. Kutikhin; Arseniy E. Yuzhalin
Название: Genomics of Pattern Recognition Receptors
ISBN: 3034807945 ISBN-13(EAN): 9783034807944
Издательство: Springer
Рейтинг:
Цена: 130590.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book details the polymorphisms of genes encoding pattern recognition receptors (PRRs). Following a short description of the general role of PRRs in the immune system, coverage examines the structure and function of Toll-like and NOD-like receptors.

Автор: Kleanthous
Название: Protein-protein Recognition.2000
ISBN: 0199637601 ISBN-13(EAN): 9780199637607
Издательство: Oxford Academ
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Цена: 116160.00 T
Наличие на складе: Невозможна поставка.
Описание: Protein-protein recognition is a critical event controlling in a large number of cell processes and therefore is of interest to a large section of the biological community. The purpose of this book is to bring together important concepts and systems in a single volume.

Автор: Ben-Naim Arieh
Название: Molecular Theory Of Water And Aqueous Solutions - Part Ii: The Role Of Water In Protein Folding, Self-Assembly And Molecular Recognition
ISBN: 9814350540 ISBN-13(EAN): 9789814350549
Издательство: World Scientific Publishing
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Цена: 28510.00 T
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Описание: Starts out by presenting the evidence for hydrophilic interactions in biochemical processes and then goes on to describe the applications of the hydrophilic interactions in these processes, specifically protein folding, protein association, self assembly and molecular recognition.

Автор: Ming-Ming Zhou
Название: Histone Recognition
ISBN: 3319181017 ISBN-13(EAN): 9783319181011
Издательство: Springer
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Цена: 139750.00 T
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Описание: This book provides a timely review of the role of histone modifications in epigenetic control of gene expression. Topics covered include: basic mechanisms of molecular recognition of histone post-translational modification (PTMs); combinatorial readout of histone PTMs by tandem epigenome reader domains; genome-wide profiling of histone PTM interactions; small molecule modulation of histone PTM interactions and their potential as a new approach to therapeutic intervention in human diseases. All chapters were written by leading scientists who made the original key discoveries of the structure and mechanism of evolutionarily conserved reader domains, which serve to direct gene transcription in chromatin through interactions with DNA-packing histones in a PTM-sensitive manner.

Автор: Ming-Ming Zhou
Название: Histone Recognition
ISBN: 3319376667 ISBN-13(EAN): 9783319376660
Издательство: Springer
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Цена: 113180.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book provides a timely review of the role of histone modifications in epigenetic control of gene expression.