Blood Cell Biochemistry, Anthony D. Whetton; John Gordon

Автор: Leslie J. Fairbairn; Nydia G. Testa
Название: Blood Cell Biochemistry
ISBN: 0306459620 ISBN-13(EAN): 9780306459627
Издательство: Springer
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Цена: 222670.00 T
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Описание: This volume focuses specifically on gene therapy in the haematopietic system, its applications, potentials and problems, and provides insight into how the haematopietic system may be considered as a target in therapy of acquired and inherited disease of other tissues.

Автор: Leslie J. Fairbairn; Nydia G. Testa
Название: Blood Cell Biochemistry
ISBN: 1461372186 ISBN-13(EAN): 9781461372189
Издательство: Springer
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Цена: 139750.00 T
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Описание: The chapters in this book evaluate the need for gene therapy in the hematopoietic system, discuss how efficient gene transfer and expression can be achieved in the target cells, highlight areas of difficulty to be addressed, and examine a number of potential applications of the gene therapy approach.

Автор: J. Robin Harris
Название: Blood Cell Biochemistry Volume 3
ISBN: 1461366925 ISBN-13(EAN): 9781461366928
Издательство: Springer
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Цена: 46570.00 T
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Автор: Anthony D. Whetton; John Gordon
Название: Blood Cell Biochemistry
ISBN: 1475770529 ISBN-13(EAN): 9781475770520
Издательство: Springer
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Цена: 186330.00 T
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Описание: Historically, the field of hematopoietic growth factor research began with the work of Carnot and Deflandre-in 1906 they suggested that the rate of erythropoiesis is regulated by a humoral factor found in the blood, namely, erythropoietin.

Автор: Rafik Galimzyanovich Sajfutdinov; Lyudmila Ivanovn
Название: Electron Paramagnetic Resonance in Biochemistry and Medicine
ISBN: 1475786891 ISBN-13(EAN): 9781475786897
Издательство: Springer
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Цена: 74530.00 T
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Описание: Electron Paramagnetic Resonance (EPR) spectroscopy - also sometimes termed Electron Spin Resonance spectroscopy - has manifold potential uses in biochemistry and medicine.

Автор: Bernd Nilius; Pieter de Tombe; Thomas Gudermann; R
Название: Reviews of Physiology, Biochemistry and Pharmacology, Vol. 173
ISBN: 3319613669 ISBN-13(EAN): 9783319613666
Издательство: Springer
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Цена: 121110.00 T
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Описание: Leading researchers are specially invited to provide a complete understanding of a key topic within the multidisciplinary fields of physiology, biochemistry and pharmacology. In a form immediately useful to scientists, this periodical aims to filter, highlight and review the latest developments in these rapidly advancing fields.

Автор: Nilius
Название: Reviews of Physiology, Biochemistry and Pharmacology, Vol. 171
ISBN: 3319438131 ISBN-13(EAN): 9783319438139
Издательство: Springer
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Цена: 130430.00 T
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Описание: Leading researchers are specially invited to provide a complete understanding of a key topic within the multidisciplinary fields of physiology, biochemistry and pharmacology. In a form immediately useful to scientists, this periodical aims to filter, highlight and review the latest developments in these rapidly advancing fields.

Автор: William E.M. Lands
Название: Biochemistry of Arachidonic Acid Metabolism
ISBN: 0898387175 ISBN-13(EAN): 9780898387179
Издательство: Springer
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Цена: 231990.00 T
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Описание: Prostaglandins, Leukotrienes, and Cancer is a multi-volume series that will focus on an emerging area of cancer research. In 1968, R.H. Williams first reported that elevated prostaglandin levels are present in human medullary car- cinoma. Since that time, the concept that arachidonic acid metabolites may be in- volved in cancer has expanded to include every aspect of the disease from cell transformation through metastasis. Prostaglandins and leukotrienes are generic terms used to describe a family of bioactive lipids produced from unsaturated fatty acids (principally from arachidonic acid) via the cyclooxygenase and lipoxygenase pathways, respec- tively. Cyclooxygenase products consist of diverse products such as prosta- glandin E, (POE, ), prostacyclin (POI2) and thromboxane A2 (TXA2), whereas lipoxygenase products consist of hydroperoxy fatty acids and mono-, di- and tri-hydroxy acids including leukotrienes. The precursor fatty acids for the cyclooxygenase and lip oxygenase pathways are present in cellular phospholipids. This finding established an important control point in their biosynthesis-the release of substrate. This occurs in response to numerous stimuli that act at the cell surface. Dr. Bengt Samuelsson's extensive study of the metabolism of pros- taglandins indicated that they are rapidly inactivated on a single pass through pulmonary circulation. Thus, they cannot act as circulating hormones and appear to be made on demand in or in the vicinity of target tissues leading to the concept that prostaglandins are local hormones or autocoids.

Автор: William E.M. Lands
Название: Biochemistry of Arachidonic Acid Metabolism
ISBN: 1461296277 ISBN-13(EAN): 9781461296270
Издательство: Springer
Рейтинг:
Цена: 231990.00 T
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Описание: Prostaglandins, Leukotrienes, and Cancer is a multi-volume series that will focus on an emerging area of cancer research. In 1968, R.H. Williams first reported that elevated prostaglandin levels are present in human medullary car- cinoma. Since that time, the concept that arachidonic acid metabolites may be in- volved in cancer has expanded to include every aspect of the disease from cell transformation through metastasis. Prostaglandins and leukotrienes are generic terms used to describe a family of bioactive lipids produced from unsaturated fatty acids (principally from arachidonic acid) via the cyclooxygenase and lipoxygenase pathways, respec- tively. Cyclooxygenase products consist of diverse products such as prosta- glandin E, (POE, ), prostacyclin (POI2) and thromboxane A2 (TXA2), whereas lipoxygenase products consist of hydroperoxy fatty acids and mono-, di- and tri-hydroxy acids including leukotrienes. The precursor fatty acids for the cyclooxygenase and lip oxygenase pathways are present in cellular phospholipids. This finding established an important control point in their biosynthesis-the release of substrate. This occurs in response to numerous stimuli that act at the cell surface. Dr. Bengt Samuelsson's extensive study of the metabolism of pros- taglandins indicated that they are rapidly inactivated on a single pass through pulmonary circulation. Thus, they cannot act as circulating hormones and appear to be made on demand in or in the vicinity of target tissues leading to the concept that prostaglandins are local hormones or autocoids.

Автор: R. Colin Garner; Jan Hradec
Название: Biochemistry of Chemical Carcinogenesis
ISBN: 1461278562 ISBN-13(EAN): 9781461278566
Издательство: Springer
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Цена: 81050.00 T
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Описание: The hepatocarcinogenicity of aflatoxin BI in rats, ducks and rainbow trout has been convincingly demonstrated (1). In contrast, adult mice appear to be resistant to the toxic and carcinogenic effects. Newborn and infant mice are more sensitive to the effects of different hepatocarcinogens (2,3) and also to AFB, which induced hepatomas in newborn C57BL/6 x C3H FI I mice (4). A singl dose model of aflatoxin hepatocarcinogenesis was tested in infant C57BL/6 mice. AFBI was administered i.p. on day 7 after birth and the following data were investigated: 1) Changes in the activities of microsomal cytochrome P-450 dependant enzymes and conjugating enzymes in the course of the 20-month-Iong aflatoxin hepa- tocarcinogenesis study. At intervals of 6,8,12,18 and 20 months a ter AFBI administration, the concentrations of cyt P-450 andb and the acti- 5 vities of NADPH-, NADH-cyt c reductase, AOH, ADM, EH and GST were deter- mined. 2) Effect of continually administered diethyldithiocarbamate on the course of aflatoxin carcinogenesis. MATERIALS AND METHODS Aflatoxin BI was prepared biosynthetically in our laboratory and was checked for purity chromatographically, spectrophotometrically and by NMR.

Автор: Karoly Lapis; L.A. Liotta; A.S. Rabson
Название: Biochemistry and Molecular Genetics of Cancer Metastasis
ISBN: 1461294169 ISBN-13(EAN): 9781461294160
Издательство: Springer
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Цена: 213360.00 T
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Описание: Proceedings of the Symposium on Biochemistry and Molecular Genetics of Cancer Metastasis, Bethesda, Maryland, March 18-20, 1985

Автор: Edited by Kerry Atkinson
Название: Clinical Bone Marrow and Blood Stem Cell Transplantation
ISBN: 0521829127 ISBN-13(EAN): 9780521829120
Издательство: Cambridge Academ
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Цена: 438240.00 T
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Описание: Drs Richard Champlin, Jerome Ritz, Willem Fibbe, Per Ljungman, and Malcom K. Brenner join Kerry Atkinson as editors of this definitive reference on the clinical practice and underlying science of hematopoietic stem cell transplantation. This third edition text is significantly revised and updated with 124 chapters balancing scientific explanations with practical information on patient care for all aspects of autologous, syngeneic, and allogeneic transplantation. This edition includes 18 new chapters on significant topics such as plasticity of stem cells, embryonic stem cells, and nonmyeloablative conditioning regimens. Thoroughly referenced through 2003, the chapters are divided into 15 sections, including biological background and practical procedures, clinical results, transplant-related and organ-specific complications, laboratory aspects, and developing areas, with a final 'breaking news' chapter from this rapidly evolving field. Over 170 internationally-recognized experts contributed to this authoritative and practical text that is an essential resource for hematologists, oncologists, and transplant specialists.