TRP Channels in Drug Discovery, Arpad Szallasi; Tam?s B?r?

Автор: Bernd Nilius; Veit Flockerzi
Название: Mammalian Transient Receptor Potential (TRP) Cation Channels
ISBN: 3319051601 ISBN-13(EAN): 9783319051604
Издательство: Springer
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Цена: 279500.00 T
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Описание: In this fast moving field the main goal of this volume is to provide up-to-date information on the molecular and functional properties and pharmacology of mammalian TRP channels. Leading experts in the field describe properties of a single TRP protein/channel or portray more general principles of TRP function and important pathological situations linked to mutations of TRP genes or their altered expression. Thereby this volume on Transient Receptor Potential (TRP) Channels provides valuable information for readers with different expectations and backgrounds, for those who are approaching this field of research as well as for those wanting to make a trip to TRPs.

Автор: Bernd Nilius; Veit Flockerzi
Название: Mammalian Transient Receptor Potential (TRP) Cation Channels
ISBN: 3662512238 ISBN-13(EAN): 9783662512234
Издательство: Springer
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Цена: 330870.00 T
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Описание: This book offers up-to-date information on the molecular and functional properties and pharmacology of mammalian Transient Receptor Potential channels, from close-up views of single protein/channels to broader principles of function and important pathologies.

Автор: Veit Flockerzi; Bernd Nilius
Название: Transient Receptor Potential (TRP) Channels
ISBN: 3642071147 ISBN-13(EAN): 9783642071140
Издательство: Springer
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Цена: 567410.00 T
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Описание: With contributions by numerous experts

Автор: Arpad Szallasi
Название: TRP Channels as Therapeutic Targets
ISBN: 0124200249 ISBN-13(EAN): 9780124200241
Издательство: Elsevier Science
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Цена: 154960.00 T
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Описание: TRP Channels as Therapeutic Targets: From Basic Science to Clinical Use is authored by experts across academia and industry, providing readers with a complete picture of the therapeutic potential and challenges associated with using TRP channels as drug targets. . This book offers a unique clinical approach by covering compounds that target TRP channels in pre-clinical and clinical phases, also offering a discussion of TRP channels as biomarkers. . An entire section is devoted to the novel and innovative uses of these channels across a variety of diseases, offering strategies that can be used to overcome the adverse effects of first generation TRPV1 antagonists. . Intended for all researchers and clinicians working toward the development of successful drugs targeting TRP channels, this book is an essential resource chocked full of the latest clinical data and findings.

Название: Receptor and Ion-channel Trafficking: Cell Biology of Ligand-gated and Voltage-sensitive Ion Channels
ISBN: 0192632248 ISBN-13(EAN): 9780192632241
Издательство: Oxford Academ
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Цена: 250800.00 T
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Описание: This book reviews the recent advances in our understanding of the the molecular and cellular mechanisms regulating the targeted movement (trafficking) of receptors and ion channels in neurones - mechanisms fundamental to synaptic function.

Автор: Bernd Nilius; Veit Flockerzi
Название: Mammalian Transient Receptor Potential (TRP) Cation Channels
ISBN: 364254214X ISBN-13(EAN): 9783642542145
Издательство: Springer
Рейтинг:
Цена: 354040.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: In this fast moving field the main goal of this volume is to provide up-to-date information on the molecular and functional properties and pharmacology of mammalian TRP channels. Leading experts in the field will describe properties of a single TRP protein/channel or portray more general principles of TRP function and important pathological situations linked to mutations of TRP genes or their altered expression. Thereby this volume on Transient Receptor Potential (TRP) Channels provides valuable information for readers with different expectations and backgrounds, for those who are approaching this field of research as well as for those wanting to make a trip to TRPs.

Автор: Levitan, PhD
Название: Vascular Ion Channels in Physiology and Disease
ISBN: 3319296337 ISBN-13(EAN): 9783319296333
Издательство: Springer
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Цена: 158380.00 T
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Описание: Ion channels are the major class of membrane proteins responsible for rapid and regulated transport of ions across biological membranes and for the generation and propagation of electrical signals in the brain, heart, and skeletal and vascular tissues. Ion channels are also known to play critical roles in regulation of cell proliferation, insulin secretion and intracellular signaling in a variety of cell types. This book focuses on the roles of ion channels in vascular tissues under normal and pathological conditions. Vascular abnormalities are known to underlie a plethora of severe pathological conditions, such as atherosclerosis, systemic and pulmonary hypertension, coronary or cerebral vasospasm, and diabetes. In addition, misregulated angiogenesis is one of the major contributors to the development of tumors. Therefore, it is clearly imperative to obtain a better understanding of the molecular mechanisms that contribute to vascular disorders. This book will be the first comprehensive assembly of assays to present the studies that have been done during the last decade to elucidate the roles of ion channels in different vascular diseases.

Автор: Norbert Weiss; Alexandra Koschak
Название: Pathologies of Calcium Channels
ISBN: 364240281X ISBN-13(EAN): 9783642402814
Издательство: Springer
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Цена: 174150.00 T
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Описание: Calcium ions are crucial regulators of human physiology and development. This comprehensive guide to the molecular and clinical characteristics of the channels by which they cross membranes covers the diseases affecting them and a range of promising therapies.

Автор: Show-Ling Shyng; Francis I. Valiyaveetil; Matt Who
Название: Potassium Channels
ISBN: 1493973614 ISBN-13(EAN): 9781493973613
Издательство: Springer
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Цена: 111790.00 T
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Описание: This volume provides readers with the latest techniques and approaches used to study K+ channels.

Автор: Peter C. Ruben
Название: Voltage Gated Sodium Channels
ISBN: 3642415873 ISBN-13(EAN): 9783642415876
Издательство: Springer
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Цена: 307450.00 T
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Описание: A number of techniques to study ion channels have been developed since the electrical basis of excitability was first discovered. Ion channel biophysicists have at their disposal a rich and ever-growing array of instruments and reagents to explore the biophysical and structural basis of sodium channel behavior. Armed with these tools, researchers have made increasingly dramatic discoveries about sodium channels, culminating most recently in crystal structures of voltage-gated sodium channels from bacteria. These structures, along with those from other channels, give unprecedented insight into the structural basis of sodium channel function. This volume of the Handbook of Experimental Pharmacology will explore sodium channels from the perspectives of their biophysical behavior, their structure, the drugs and toxins with which they are known to interact, acquired and inherited diseases that affect sodium channels and the techniques with which their biophysical and structural properties are studied.