Автор: Bernard Testa Название: Pharmacokinetic Optimization in Drug Research: Biological, Physicochemical, and Computational Strategies ISBN: 3906390225 ISBN-13(EAN): 9783906390222 Издательство: Wiley Рейтинг: Цена: 153120.00 T Наличие на складе: Невозможна поставка. Описание: In this age of combinatorial chemistry and high-throughput technologies, bioactive compounds called hits are discovered by the thousands. However, the road that leads from hits to lead compounds and then to pharmacokinetically optimized clinical and drug candidates is very long indeed. As a result, the screening, design, and optimization of pharmacokinetic properties has become the bottleneck and a major challenge in drug research. To shorten the time-consuming develop-ment and high rate of attrition of active compounds ultimately doomed by hidden pharmacokinetic defects, drug researchers are coming to incorporate structure-permeation, structure-distribution, structure-metabolism, and structure-toxicity relations into drug-design strategies. To this end, powerful biological, physicochemical, and computational approaches are being developed whose objectives are to increase the clinical relevance of drug design, and to eliminate as soon as possible compounds with unfavorable physicochemical properties and pharmacokinetic profiles. Toxicological issues are also of utmost importance in this paradigm. There was, hence, an urgent need for a book covering this field in an authoritative, didactic, comprehensive, factual, and conceptual manner. In this work of unique breadth and depth, international authorities and practicing experts from academia and industry present the most modern biological, physicochemical, and computational strategies to optimize gastrointestinal absorption, protein binding and distribution, brain permeation, and metabolic profile. The biological strategies emphasized in the book include cell cultures and high-throughput screens. The physicochemical strategies focus on the determination and interpretation of solubility, lipophilicity, and related molecular properties as factors and predictors of pharmacokinetic bahavior. Particular attention is paid to the lipophilicity profiles of ionized compounds, to lipophicity measurements in anisotropic media (liposomes/water, IAM columns), and to permeability across artificial membranes. Computational strategies comprise virtual screening, molecular modelling, lipophilicity, and H-bonding fields and their importance for structure-disposition relations. This book is both about theoretical and technological breakthroughs. Thus, molecular properties are contemplated from a dual perspective, namely a) their interpretation in biological and/or physicochemical terms, and b) their value in screening, lead optimization, and drug-candidate selection. In addition to its 33 chapters, the book includes a CD-ROM containing the invited lectures, oral communications and posters (in full version) presented at the Second LogP Symposium, 'Lipophilicity in Drug Disposition -- Practical and Computational Approaches to Molecular Properties Related to Drug Permeation, Disposition and Metabolism', held at the University of Lausanne in March 2000.
Автор: Jacques Huyghe; Peter A.C. Raats; Stephen C. Cowin Название: IUTAM Symposium on Physicochemical and Electromechanical, Interactions in Porous Media ISBN: 9048169844 ISBN-13(EAN): 9789048169849 Издательство: Springer Рейтинг: Цена: 213360.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The purpose of the IUTAM symposium from which this proceedings volume has been compiled was to dive deep into the mechanics of those porous media that involve mechanics and chemistry, mechanics and electromagnetism, mechanics and thermal fluctuations of mechanics and biology.
Название: Physicochemical Aspects of Polymer Surfaces ISBN: 0306411903 ISBN-13(EAN): 9780306411908 Издательство: Springer Рейтинг: Цена: 269260.00 T Наличие на складе: Есть у поставщика Поставка под заказ.
Over the past two decades, the rapid development of nanochemistry and nanotechnology has allowed the synthesis of various materials and oxides in the form of nanopowders making it possible to produce new energetic compositions and nanomaterials.
This book has a bottom-up structure, from nanomaterials synthesis to the application fields. Starting from aluminum nanoparticles synthesis for fuel application, it proposes a detailed state-of-the art of the different methods of preparation of aluminum-based reactive nanomaterials. It describes the techniques developed for their characterization and, when available, a description of the fundamental mechanisms responsible for their ignition and combustion. This book also presents the possibilities and limitations of different energetic nanomaterials and related structures as well as the analysis of their chemical and thermal properties. The whole is rounded off with a look at the performances of reactive materials in terms of heat of reaction and reactivity mainly characterized as the self-sustained combustion velocity. The book ends up with a description of current reactive nanomaterials applications underlying the promising integration of aluminum-based reactive nanomaterial into micro electromechanical systems.
Автор: Valko Название: Physicochemical and Biomimetic Properties in Drug Discovery - Chromatographic Techniques for Lead Optimization ISBN: 1118152123 ISBN-13(EAN): 9781118152126 Издательство: Wiley Рейтинг: Цена: 125610.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Demonstrating how and why to measure physicochemical and biomimetic properties in early stages of drug discovery for lead optimization, this book encourages readers to discover relationships between various measurements and develop a sense of interdisciplinary thinking that will add to new research in drug discovery.
Автор: Suojiang Zhang; Qing Zhou; Xingmei Lu; Yuting Song Название: Physicochemical Properties of Ionic Liquid Mixtures ISBN: 9401775710 ISBN-13(EAN): 9789401775717 Издательство: Springer Рейтинг: Цена: 186330.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
Part I Ionic Liquids Database.- Ionic Liquids Database.- Introduction.- Properties of Multi-Systems Containing Ionic Liquids.- The Usage of Database.- Part II Properties of Multi-Systems Containing Ionic Liquids.- Systems Containing Imidazolium Ionic Liquids.- Systems Containing 1-Alkyl Imidazolium Ionic Liquids.- Systems Containing 1,3-Dialkyl Imidazolium Ionic Liquids.- Systems Containing Tri-Alkyl Imidazolium Ionic Liquids.- Systems Containing Pyrrolidinium Ionic Liquids.- Systems Containing Piperidinium Ionic Liquids.- Systems Containing Pyridinium Ionic Liquids.- Systems Containing Isoquinolinium Ionic Liquids.- Systems Containing Ammonium Ionic Liquids.- Systems Containing Phosphonium Ionic Liquids.
Автор: Manual G. Verlarde Название: Physicochemical Hydrodynamics ISBN: 1461280427 ISBN-13(EAN): 9781461280422 Издательство: Springer Рейтинг: Цена: 81050.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: ), CSIC (Spain), EPS, ERT (Spain), ESA, Fotonica (Spain), IBM-Espana (Spain), Junta De Andalucia (Spain), NATO, NSF (U.
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