Physicochemical Properties of Ionic Liquid Mixtures, Suojiang Zhang; Qing Zhou; Xingmei Lu; Yuting Song
Автор: Bernard Testa Название: Pharmacokinetic Optimization in Drug Research: Biological, Physicochemical, and Computational Strategies ISBN: 3906390225 ISBN-13(EAN): 9783906390222 Издательство: Wiley Рейтинг: Цена: 153120.00 T Наличие на складе: Невозможна поставка. Описание: In this age of combinatorial chemistry and high-throughput technologies, bioactive compounds called hits are discovered by the thousands. However, the road that leads from hits to lead compounds and then to pharmacokinetically optimized clinical and drug candidates is very long indeed. As a result, the screening, design, and optimization of pharmacokinetic properties has become the bottleneck and a major challenge in drug research. To shorten the time-consuming develop-ment and high rate of attrition of active compounds ultimately doomed by hidden pharmacokinetic defects, drug researchers are coming to incorporate structure-permeation, structure-distribution, structure-metabolism, and structure-toxicity relations into drug-design strategies. To this end, powerful biological, physicochemical, and computational approaches are being developed whose objectives are to increase the clinical relevance of drug design, and to eliminate as soon as possible compounds with unfavorable physicochemical properties and pharmacokinetic profiles. Toxicological issues are also of utmost importance in this paradigm. There was, hence, an urgent need for a book covering this field in an authoritative, didactic, comprehensive, factual, and conceptual manner. In this work of unique breadth and depth, international authorities and practicing experts from academia and industry present the most modern biological, physicochemical, and computational strategies to optimize gastrointestinal absorption, protein binding and distribution, brain permeation, and metabolic profile. The biological strategies emphasized in the book include cell cultures and high-throughput screens. The physicochemical strategies focus on the determination and interpretation of solubility, lipophilicity, and related molecular properties as factors and predictors of pharmacokinetic bahavior. Particular attention is paid to the lipophilicity profiles of ionized compounds, to lipophicity measurements in anisotropic media (liposomes/water, IAM columns), and to permeability across artificial membranes. Computational strategies comprise virtual screening, molecular modelling, lipophilicity, and H-bonding fields and their importance for structure-disposition relations. This book is both about theoretical and technological breakthroughs. Thus, molecular properties are contemplated from a dual perspective, namely a) their interpretation in biological and/or physicochemical terms, and b) their value in screening, lead optimization, and drug-candidate selection. In addition to its 33 chapters, the book includes a CD-ROM containing the invited lectures, oral communications and posters (in full version) presented at the Second LogP Symposium, 'Lipophilicity in Drug Disposition -- Practical and Computational Approaches to Molecular Properties Related to Drug Permeation, Disposition and Metabolism', held at the University of Lausanne in March 2000.
Автор: Valko Название: Physicochemical and Biomimetic Properties in Drug Discovery - Chromatographic Techniques for Lead Optimization ISBN: 1118152123 ISBN-13(EAN): 9781118152126 Издательство: Wiley Рейтинг: Цена: 125610.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Demonstrating how and why to measure physicochemical and biomimetic properties in early stages of drug discovery for lead optimization, this book encourages readers to discover relationships between various measurements and develop a sense of interdisciplinary thinking that will add to new research in drug discovery.
This book summarizes science and technology of a new generation of high-energy and
insensitive explosives. The objective is to provide professionals with comprehensive
information on the synthesis and the physicochemical and detonation properties of
the explosives. Potential technologies applicable for treatment of contaminated waste
streams from manufacturing facilities and environmental matrices are also be included.
This book provides the reader an insight into the depth and breadth of theoretical
and empirical models and experimental techniques currently being developed in the
field of energetic materials. It presents the latest research by DoD engineers and
scientists, and some of DoD’s academic and industrial researcher partners. The topics
explored and the simulations developed or modified for the purposes of energetics may
find application in other closely related fields, such as the pharmaceutical industry.
One of the key features of the book is the treatment of wastewaters generated during
manufacturing of these energetic materials.
Автор: Jacques Huyghe; Peter A.C. Raats; Stephen C. Cowin Название: IUTAM Symposium on Physicochemical and Electromechanical, Interactions in Porous Media ISBN: 9048169844 ISBN-13(EAN): 9789048169849 Издательство: Springer Рейтинг: Цена: 213360.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The purpose of the IUTAM symposium from which this proceedings volume has been compiled was to dive deep into the mechanics of those porous media that involve mechanics and chemistry, mechanics and electromagnetism, mechanics and thermal fluctuations of mechanics and biology.
Автор: Manual G. Verlarde Название: Physicochemical Hydrodynamics ISBN: 1461280427 ISBN-13(EAN): 9781461280422 Издательство: Springer Рейтинг: Цена: 81050.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: ), CSIC (Spain), EPS, ERT (Spain), ESA, Fotonica (Spain), IBM-Espana (Spain), Junta De Andalucia (Spain), NATO, NSF (U.
Название: Physicochemical Aspects of Polymer Surfaces ISBN: 0306411903 ISBN-13(EAN): 9780306411908 Издательство: Springer Рейтинг: Цена: 269260.00 T Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Ralph G. Scurlock Название: Stratification, Rollover and Handling of LNG, LPG and Other Cryogenic Liquid Mixtures ISBN: 3319206958 ISBN-13(EAN): 9783319206950 Издательство: Springer Рейтинг: Цена: 47880.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This short, practical book offers advice on the safe storage, handling and transportation of liquid natural gas (LNG), liquid petroleum gas (LPG) and other cryogenic fluid mixtures. The chapters that follow address more in-depth topics such as heat flows in LNG and LPG storage systems, insulation techniques and surface evaporation phenomena.
Автор: D.J. Walsh; J.S. Higgins; A. Maconnachie Название: Polymer Blends and Mixtures ISBN: 9401087555 ISBN-13(EAN): 9789401087551 Издательство: Springer Рейтинг: Цена: 81050.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Proceedings of the NATO Advanced Study Institute on Polymer Blends and Mixture, Imperial College, London, England, July 2-14, 1984
Автор: George Z Voyiadjis; C.R. Song Название: The Coupled Theory of Mixtures in Geomechanics with Applications ISBN: 3642064221 ISBN-13(EAN): 9783642064227 Издательство: Springer Рейтинг: Цена: 111790.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The stresses carried by the solid skeleton are typically termed "e?ective stress" while the stresses carried by the pore liquid are termed "pore pressure. Due to the leak of pore pressure, the pore pressure changes with time, and the e?ective stress changes and the skeleton deforms with time accordingly.
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