Translational Bioinformatics and Systems Biology Methods for Pers, Yan, Qing

Автор: Martin Wehling
Название: Principles of Translational Science in Medicine
ISBN: 0128006870 ISBN-13(EAN): 9780128006870
Издательство: Elsevier Science
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Цена: 106660.00 T
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Описание: Principles of Translational Science in Medicine: From Bench to Bedside, Second Edition, provides an update on major achievements in the translation of research into medically relevant results and therapeutics. . The book presents a thorough discussion of biomarkers, early human trials, and networking models, and includes institutional and industrial support systems. It also covers algorithms that have influenced all major areas of biomedical research in recent years, resulting in an increasing numbers of new chemical/biological entities (NCEs or NBEs) as shown in FDA statistics. The book is ideal for use as a guide for biomedical scientists to establish a systematic approach to translational medicine.

Автор: Gary Hime (Editor), Helen Abud (Editor)
Название: Transcriptional and Translational Regulation of Stem Cells (Advances in Experimental Medicine and Biology)
ISBN: 9400766203 ISBN-13(EAN): 9789400766204
Издательство: Springer
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Цена: 158380.00 T
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Описание: This volume takes two approaches to this topic - (1) illustrating the general principles outlined above through a series of different stem cell examples - embryonic, iPS and adult stem cells, and (2) describing several molecular families that have been shown to have roles in regulation of multiple stem cell populations.

Автор: Robbins
Название: Translational Neuropsychopharmacology
ISBN: 3319339117 ISBN-13(EAN): 9783319339115
Издательство: Springer
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Цена: 156720.00 T
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Описание: This book covers wide areas of animal and human psychopharmacology with clinical utility in the treatment of psychiatric and neurological (e.g Alzheimer's disease) disorders. The main theme is to develop a new paradigm for drug discovery that questions the claim that animal models or assays fail adequately to predict Phase 3 clinical trials. A new paradigm is advocated that stresses the importance of intermediate staging points between these extremes that depend on suitable translation of findings from animal studies to Phase 1 or Phase 2 studies utilising experimental medicine.

Автор: Grant
Название: Analysis of Post-Translational Modifications and Proteolysis in Neuroscience
ISBN: 1493934708 ISBN-13(EAN): 9781493934706
Издательство: Springer
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Цена: 130430.00 T
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Описание: This volume highlights proteomics studies of quantitative PTM changes in both peripheral and central nervous system proteomes utilizing the most recent advances in mass spectrometry. Chapters include practical information pertaining to the fundamentals of sample preparation, liquid chromatography, and tandem mass spectrometry instrumental analysis and will elucidate best practices in the interpretation of data using modern bioinformatics approaches. Written for the popular Neuromethods series, chapters include the kind of detail and key implementation advice that ensures successful results in the laboratory.Authoritative and practical, Analysis of Post-Translational Modifications and Proteolysis in Neuroscience aims to ensure successful results in the further study of this vital field.

Автор: Srivastava Rakesh Et Al
Название: Lost In Translation: Barriers To Incentives For Translational Research In Medical Sciences
ISBN: 9814489069 ISBN-13(EAN): 9789814489065
Издательство: World Scientific Publishing
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Цена: 258720.00 T
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Описание: This book is all about the definition and finding ways to prioritize and accelerate translation research in biomedical sciences and rapidly turning new knowledge into first-in-human studies. It represents an effort to bring together scientists active in various areas of translational research to share science and, hopefully, generate new ideas and potential collaborations. The book provides a comprehensive overview of translational work that includes significant discoveries and pioneering contributions, e.g., in immunology, gene therapy, stem cells and population sciences. It may be used as an advanced textbook by graduate students and even ambitious undergraduates in biomedical sciences. It is also suitable for non-experts, i.e. medical doctors, who wish to have an overview of some of the fundamental models in translational research.Managing the translational enterprise remains a work in progress. The world is changing rapidly, and the scientific world needs to seek new ways to ensure that discoveries get translated for patients efficiently and as quickly as possible. In addition, everyone expects the investment in biomedical research should pay dividends through effective therapeutic solutions. This unique project provides a broad collaborative approach of the international scientific team to present its view and opinion how to cross barriers to incentives for translational research in medical sciences.Contributing to the book is an international team of prominent co-authors. The book consists of unique and widely treated topics, and includes new hypotheses, data and analyses.