Genomic and Precision Medicine, Ginsburg, Geoffrey S.
Автор: Geoffrey S. Ginsburg Название: Genomic and Personalized Medicine, ISBN: 0123822270 ISBN-13(EAN): 9780123822277 Издательство: Elsevier Science Цена: 338970.00 T Наличие на складе: Невозможна поставка. Описание: Genomic and Personalized Medicine, Second Edition - winner of a 2013 Highly Commended BMA Medical Book Award for Medicine - is a major discussion of the structure, history, and applications of the field, as it emerges from the campus and lab into clinical action. As with the first edition, leading experts review the development of the new science, the current opportunities for genome-based analysis in healthcare, and the potential of genomic medicine in future healthcare. The inclusion of the latest information on diagnostic testing, population screening, disease susceptability, and pharmacogenomics makes this work an ideal companion for the many stakeholders of genomic and personalized medicine.
With advancing knowledge of the genome across and outside protein-coding regions of DNA, new comprehension of genomic variation and frequencies across populations, the elucidation of advanced strategic approaches to genomic study, and above all in the elaboration of next-generation sequencing, genomic medicine has begun to achieve the much-vaunted transformative health outcomes of the Human Genome Project, almost a decade after its official completion in April 2003. * Highly Commended 2013 BMA Medical Book Award for Medicine* More than 100 chapters, from leading researchers, review the many impacts of genomic discoveries in clinical action, including 63 chapters new to this edition* Discusses state-of-the-art genome technologies, including population screening, novel diagnostics, and gene-based therapeutics* Wide and inclusive discussion encompasses the formidable ethical, legal, regulatory and social challenges related to the evolving practice of genomic medicine* Clearly and beautifully illustrated with 280 color figures, and many thousands of references for further reading and deeper analysis
Автор: Cornel Mulhardt Название: Molecular Biology and Genomics, ISBN: 0120885468 ISBN-13(EAN): 9780120885466 Издательство: Elsevier Science Рейтинг: Цена: 45150.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Never before has it been so critical for lab workers to possess the proper tools and methodologies necessary to determine the structure, function, and expression of the corresponding proteins encoded in the genome. Mulhardt's Molecular Biology and Genomics helps aid in this daunting task by providing the reader with tips and tricks for more successful lab experiments. This strategic lab guide explores the current methodological variety of molecular biology and genomics in a simple manner, addressing the assets and drawbacks as well as critical points. It also provides short and precise summaries of routine procedures as well as listings of the advantages and disadvantages of alternative methods.
At a ceremony announcing the completion of the first draft of the human genome in 2000, President Bill Clinton declared, "I believe one of the great truths to emerge from this triumphant expedition inside the human genome is that in genetic terms, all human beings, regardless of race, are more than 99.9 percent the same." Yet despite this declaration of unity, biomedical research has focused increasingly on mapping that.1 percent of difference, particularly as it relates to race.
This trend is exemplified by the drug BiDil. Approved by the FDA in 2005 as the first drug with a race-specific indication on its label, BiDil was originally touted as a pathbreaking therapy to treat heart failure in black patients and help underserved populations. Upon closer examination, however, Jonathan Kahn reveals a far more complex story. At the most basic level, BiDil became racial through legal maneuvering and commercial pressure as much as through medical understandings of how the drug worked.
Using BiDil as a central case study, Kahn broadly examines the legal and commercial imperatives driving the expanding role of race in biomedicine, even as scientific advances in genomics could render the issue irrelevant. He surveys the distinct politics informing the use of race in medicine and the very real health disparities caused by racism and social injustice that are now being cast as a mere function of genetic difference. Calling for a more reasoned approach to using race in biomedical research and practice, Kahn asks readers to recognize that, just as genetics is a complex field requiring sensitivity and expertise, so too is race, particularly in the field of biomedicine.
Автор: Geoffrey S. Ginsburg Название: Genomic and Personalized Medicine ISBN: 0128006811 ISBN-13(EAN): 9780128006818 Издательство: Elsevier Science Рейтинг: Цена: 101050.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
Genomic and Precision Medicine: Foundations, Translation, and Implementation highlights the various points along the continuum from health to disease where genomic information is impacting clinical decision-making and leading to more personalization of health care.
The book pinpoints the challenges, barriers, and solutions that have been, or are being, brought forward to enable translation of genome based technologies into health care. A variety of infrastructure (data systems and EMRs), policy (regulatory, reimbursement, privacy), and research (comparative effectiveness research, learning health system approaches) strategies are also discussed. Readers will find this volume to be an invaluable resource for the translational genomics and implementation science that is required to fully realize personalized health care.
Provides a comprehensive volume on the translation and implementation of biology into health care provision
Presents succinct commentary and key learning points that will assist readers with their local needs for translation and implementation
Includes an up-to-date overview on major 'translational events' in genomic and personalized medicine, along with lessons learned
Автор: Willard Название: Genomic and Personalized Medicine, 2-Vols-Set (Vol 1: 9780123708885, Vol 2: 9780123708892,€170/?115 each ISBN: 0123694205 ISBN-13(EAN): 9780123694201 Издательство: Elsevier Science Рейтинг: Цена: 289850.00 T Наличие на складе: Невозможна поставка. Описание: Offers information on genomic applications and impact on medicine to the major disease groups: Cancer, Cardiovascular, Infectious Disease, Neurological, Renal, Psychiatric, Nutrition/Metabolism, Chronic Inflammatory. This book discusses genetic counseling and ethical, legal/regulatory, and social issues related to the practice of genomic medicine.
Автор: Joel Weller Название: Genomic Selection in Animals ISBN: 0470960078 ISBN-13(EAN): 9780470960073 Издательство: Wiley Рейтинг: Цена: 138280.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The field of whole genome selection has quickly developed into the breeding methodology of the future. As efforts to map a wide variety of animal genomes have matured and full animal genomes are now available for many animal scientists and breeders are looking to apply these techniques to livestock production.
Автор: Geoffrey S. Ginsburg Название: Essentials of Genomic and Personalized Medicine, ISBN: 0123749344 ISBN-13(EAN): 9780123749345 Издательство: Elsevier Science Рейтинг: Цена: 101200.00 T Наличие на складе: Невозможна поставка. Описание: Derived from the comprehensive two-volume set, <i>Genomic and Personalized Medicine</i> also edited by Drs. Willard and Ginsburg, this work serves the needs of the evolving population of scientists, researchers, practitioners and students that are embracing one of the most promising avenues for advances in diagnosis, prevention and treatment of human disease. From principles, methodology and translational approaches to genome discoveries and clinical applications, <i>Essentials of Genomic and Personalized Medicine</i> will be a valuable resource for various professionals and students across medical disciplines, including human genetics and genomics, oncology, neuroscience, gene therapy, molecular medicine, pharmacology, and biomedical sciences. Updates with regard to diagnostic testing, pharmacogenetics, predicting disease susceptibility, and other important research components as well as chapters dedicated to cardiovascular disease, oncology, inflammatory disease, metabolic disease, neuropsychiatric disease, and infectious disease, present this book as an essential tool for a variety of professionals and students who are endeavouring into the developing the diverse and practical field of genomic and personalized medicine. <br><br>* Full color throughout<br>* Includes contributions on genetic counselling, ethical, legal/regulatory, and social issues related to the practice of genomic medicine from leaders in the field <br>* Introductory chapter highlights differences between personalized and traditional medicine, promising areas of current research, and challenges to incorporate the latest research discoveries and practice<br>* Ancillary material includes case studies and lab questions which highlight the collaborative approach to the science
Автор: Kumar, Dhavendra; Eng, Charis Название: Genomic Medicine ISBN: 019989602X ISBN-13(EAN): 9780199896028 Издательство: Oxford Academ Рейтинг: Цена: 301840.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The first edition of Genomics and Clinical Medicine provided an overview of genomics-based advances in disease susceptibility, diagnosis, and prediction of treatment outcomes in various areas of medicine. Since its publication, the science of genomics has made tremendous progress, and exciting new developments in biotechnology and bioinformatics have created possibilities that were inconceivable only a few years ago. This completely revised second edition ofGenomic Medicine reflects the rapidly changing face of applied and translational genomics in the medical and health context and provides a comprehensive coverage of principles of genetics and genomics relevant to the practice of medicine.
Автор: Pierce Benjamin A Название: Genetics Essentials. Concepts and Connections. - 3th ed. ISBN: 1464190755 ISBN-13(EAN): 9781464190759 Издательство: Springer Рейтинг: Цена: 60550.00 T Наличие на складе: Поставка под заказ. Описание: Derived from Ben Pierce's popular and acclaimed Genetics: A Conceptual Approach, this streamlined text covers basic transmission, molecular, and population genetics.
Автор: Mccarthy Название: Precision Medicine: A Guide To Genomics In Clinical Practice ISBN: 1259644138 ISBN-13(EAN): 9781259644139 Издательство: McGraw-Hill Рейтинг: Цена: 101810.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: A complete how-to-guide for incorporating precision medicine into any type of practice
Автор: Verma, Mukesh Название: Progress and Challenges in Precision Medicine ISBN: 0128094117 ISBN-13(EAN): 9780128094112 Издательство: Elsevier Science Рейтинг: Цена: 117900.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
Progress and Challenges in Precision Medicine presents an insightful overview to the myriad factors of personalized and precision medicine. The availability of the human genome, large amounts of data on individual genetic variations, environmental interactions, influence of lifestyle, and cutting-edge tools and technologies for big-data analysis have led to the age of personalized and precision medicine.
Bringing together a global range of experts on precision medicine, this book collects previously scattered information into one concise volume which covers the most important developments so far in precision medicine and also suggests the most likely avenues for future development.
The book includes clinical information, informatics, public policy implications, and information on case studies. It is a useful reference and background work for students, researchers, and clinicians working in the biomedical and medical fields, as well as policymakers in the health sciences.
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