Essentials of Genomic and Personalized Medicine,, Geoffrey S. Ginsburg
Автор: Geoffrey S. Ginsburg Название: Genomic and Personalized Medicine, ISBN: 0123822270 ISBN-13(EAN): 9780123822277 Издательство: Elsevier Science Цена: 338970.00 T Наличие на складе: Невозможна поставка. Описание: Genomic and Personalized Medicine, Second Edition - winner of a 2013 Highly Commended BMA Medical Book Award for Medicine - is a major discussion of the structure, history, and applications of the field, as it emerges from the campus and lab into clinical action. As with the first edition, leading experts review the development of the new science, the current opportunities for genome-based analysis in healthcare, and the potential of genomic medicine in future healthcare. The inclusion of the latest information on diagnostic testing, population screening, disease susceptability, and pharmacogenomics makes this work an ideal companion for the many stakeholders of genomic and personalized medicine.
With advancing knowledge of the genome across and outside protein-coding regions of DNA, new comprehension of genomic variation and frequencies across populations, the elucidation of advanced strategic approaches to genomic study, and above all in the elaboration of next-generation sequencing, genomic medicine has begun to achieve the much-vaunted transformative health outcomes of the Human Genome Project, almost a decade after its official completion in April 2003. * Highly Commended 2013 BMA Medical Book Award for Medicine* More than 100 chapters, from leading researchers, review the many impacts of genomic discoveries in clinical action, including 63 chapters new to this edition* Discusses state-of-the-art genome technologies, including population screening, novel diagnostics, and gene-based therapeutics* Wide and inclusive discussion encompasses the formidable ethical, legal, regulatory and social challenges related to the evolving practice of genomic medicine* Clearly and beautifully illustrated with 280 color figures, and many thousands of references for further reading and deeper analysis
Автор: Cornel Mulhardt Название: Molecular Biology and Genomics, ISBN: 0120885468 ISBN-13(EAN): 9780120885466 Издательство: Elsevier Science Рейтинг: Цена: 45150.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Never before has it been so critical for lab workers to possess the proper tools and methodologies necessary to determine the structure, function, and expression of the corresponding proteins encoded in the genome. Mulhardt's Molecular Biology and Genomics helps aid in this daunting task by providing the reader with tips and tricks for more successful lab experiments. This strategic lab guide explores the current methodological variety of molecular biology and genomics in a simple manner, addressing the assets and drawbacks as well as critical points. It also provides short and precise summaries of routine procedures as well as listings of the advantages and disadvantages of alternative methods.
Автор: Kumar, Dhavendra; Eng, Charis Название: Genomic Medicine ISBN: 019989602X ISBN-13(EAN): 9780199896028 Издательство: Oxford Academ Рейтинг: Цена: 301840.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The first edition of Genomics and Clinical Medicine provided an overview of genomics-based advances in disease susceptibility, diagnosis, and prediction of treatment outcomes in various areas of medicine. Since its publication, the science of genomics has made tremendous progress, and exciting new developments in biotechnology and bioinformatics have created possibilities that were inconceivable only a few years ago. This completely revised second edition ofGenomic Medicine reflects the rapidly changing face of applied and translational genomics in the medical and health context and provides a comprehensive coverage of principles of genetics and genomics relevant to the practice of medicine.
Автор: Bolouri Hamid Название: Personal genomics and personalized medicine 2010 ISBN: 184816565X ISBN-13(EAN): 9781848165656 Издательство: World Scientific Publishing Рейтинг: Цена: 42330.00 T Наличие на складе: Невозможна поставка. Описание: Provides a scientific treatment of the disciplines of personal genomics and personalized medicine. This book includes a comprehensive treatment of both the promises and challenges of personal genomics and medicine from technological, societal and medical perspectives. It is suitable for practicing health professionals and researchers.
Автор: Willard Название: Genomic and Personalized Medicine, 2-Vols-Set (Vol 1: 9780123708885, Vol 2: 9780123708892,€170/?115 each ISBN: 0123694205 ISBN-13(EAN): 9780123694201 Издательство: Elsevier Science Рейтинг: Цена: 289850.00 T Наличие на складе: Невозможна поставка. Описание: Offers information on genomic applications and impact on medicine to the major disease groups: Cancer, Cardiovascular, Infectious Disease, Neurological, Renal, Psychiatric, Nutrition/Metabolism, Chronic Inflammatory. This book discusses genetic counseling and ethical, legal/regulatory, and social issues related to the practice of genomic medicine.
Автор: Pierce Benjamin A Название: Genetics Essentials. Concepts and Connections. - 3th ed. ISBN: 1464190755 ISBN-13(EAN): 9781464190759 Издательство: Springer Рейтинг: Цена: 60550.00 T Наличие на складе: Поставка под заказ. Описание: Derived from Ben Pierce's popular and acclaimed Genetics: A Conceptual Approach, this streamlined text covers basic transmission, molecular, and population genetics.
Автор: Geoffrey S. Ginsburg Название: Genomic and Personalized Medicine ISBN: 0128006811 ISBN-13(EAN): 9780128006818 Издательство: Elsevier Science Рейтинг: Цена: 101050.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
Genomic and Precision Medicine: Foundations, Translation, and Implementation highlights the various points along the continuum from health to disease where genomic information is impacting clinical decision-making and leading to more personalization of health care.
The book pinpoints the challenges, barriers, and solutions that have been, or are being, brought forward to enable translation of genome based technologies into health care. A variety of infrastructure (data systems and EMRs), policy (regulatory, reimbursement, privacy), and research (comparative effectiveness research, learning health system approaches) strategies are also discussed. Readers will find this volume to be an invaluable resource for the translational genomics and implementation science that is required to fully realize personalized health care.
Provides a comprehensive volume on the translation and implementation of biology into health care provision
Presents succinct commentary and key learning points that will assist readers with their local needs for translation and implementation
Includes an up-to-date overview on major 'translational events' in genomic and personalized medicine, along with lessons learned
Автор: Kaput Название: Nutritional Genomics: Discovering the Path to Personalized Nutrition. 2006 ISBN: 0471683191 ISBN-13(EAN): 9780471683193 Издательство: Wiley Рейтинг: Цена: 137230.00 T Наличие на складе: Невозможна поставка. Описание: Nutritional Genomics provides an integrated and up-to-date overview of the fundamental principles and scientific methodologies that serve as the foundation for nutrigenomics. World-renowned experts in the field of nutrigenomics have contributed their latest breakthroughs and insights in their particular areas of expertise.
Автор: Jeremy Nicholson Название: Personalized Medicine and Population Screening ISBN: 0128003448 ISBN-13(EAN): 9780128003442 Издательство: Elsevier Science Рейтинг: Цена: 108920.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
Metabolic Phenotyping in Personalized and Public Healthcare provides information on the widespread recognition that a personalized or stratified approach to patient treatment may offer a more efficient and effective healthcare solution than phenotype-led approaches.
In order to achieve that objective, a deep personal description is required at the level of the genome, proteome, metabolome, or preferably a combination of these aided by technology. This book, edited and written by the outstanding luminaries of this evolving field, evaluates metabolic profiling and its uses across personalized and population healthcare, while also covering the advent of new technology fields, such as surgical metabonomics.
In addition, the text presents specific examples of where this technology has been used clinically and with efficacy, pointing towards a framework and protocol for usage as it hits the clinical mainstream.
Translates the conjunction of new surgical tools for intraoperative, real-time, metabolite evaluation and direct analysis of biofluid samples into novel options for augmented clinical decision-making
Discusses longitudinal sampling from individual patients for stratified medicine
Covers high resolution analytical spectroscopy and sophisticated computational modelling for prediction of adverse reactions in critical care scenarios, prognostic evaluation of cancer from biofluidism, and prognostic prediction of metabolism or response of patients to pharmaceutical interventions
Encapsulates recent technology options for broader population profiling considerations, in particular, the metabolome-wide association studies (MWAS) that aid the translational researcher in identifying metabolic patterns associated with disease
Foreword written by Professor Dame Sally Davies who is the Chief Medical Officer for England
Автор: Trygve Tollefsbol Название: Personalized Epigenetics ISBN: 0124201350 ISBN-13(EAN): 9780124201354 Издательство: Elsevier Science Рейтинг: Цена: 93200.00 T Наличие на складе: Невозможна поставка. Описание:
Personalized Epigenetics discusses the core translatability of epigenetics to health management of individuals who have unique variations in their epigenetic signatures that can guide both disorder and disease prevention and therapy.
The book details inter-individual variability in the major epigenetic process in humans consisting of DNA methylation, histone modifications, and noncoding RNA, and the diagnostic, prognostic, and therapeutic potential of the field, it also reviews the impact of the environment on epigenetic variations among individuals and the role of pharmacology and drug development in personalized epigenetics.
Most importantly, the text covers personalized epigenetics from a disease-oriented perspective, presenting chapters that provide advances in widespread disorders or diseases, including diabetes, cancer, autoimmune disorders, obesity, cardiovascular diseases, neurological disorders, and pain management.
Автор: Ginsburg, Geoffrey S. Название: Genomic and Precision Medicine ISBN: 0128006854 ISBN-13(EAN): 9780128006856 Издательство: Elsevier Science Рейтинг: Цена: 102130.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
Genomic and Precision Medicine: Primary Care, Third Edition is an invaluable resource on the state-of-the-art tools, technologies and policy issues that are required to fully realize personalized health care in the area of primary care.
One of the major areas where genomic and personalized medicine is most active is the realm of the primary care practitioner. Risk, family history, personal genomics and pharmacogenomics are becoming increasingly important to the PCP and their patients, and this book discusses the implications as they relate to primary care practitioners.
Presents a comprehensive volume for primary care providers
Provides succinct commentary and key learning points that will assist providers with their local needs for the implementation of genomic and personalized medicine
Includes a current overview on major opportunities for genomic and personalized medicine in practice
Highlights case studies that illustrate the practical use of genomics in the management in patients
Автор: Bulayeva Название: Genomic Architecture of Schizophrenia Across Diverse Genetic Isolates ISBN: 3319319620 ISBN-13(EAN): 9783319319629 Издательство: Springer Рейтинг: Цена: 144410.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book presents a long-term study in genetic isolates of indigenous small ethnics of Dagestan, located in the North-East part of Caucasus in Russia. Dagestan is characterized by extreme cultural and linguistic differences in a small geographic area and contains 26 indigenous ethnic groups. According to archeological data these indigenous highland ethnics have been living in the same area for more than ten thousand years. Our long-term population-genetic study of Dagestan indigenous ethnic groups indicates their close relation to each other and suggests that they evolved from one common ancestral meta-population. Dagestan has an extremely high genetic diversity between ethnic populations and a low genetic diversity within them. Such genetic isolates are exceptional resources for the detection of susceptibility genes for complex diseases because of the reduction in genetic and clinical heterogeneity. The founder effect and gene drift in these primary isolates may have caused aggregation of specific haplotypes with limited numbers of pathogenic alleles and loci in some isolates relative to others. The book presents a study in four ethnically and demographically diverse genetic isolates with aggregation of schizophrenia that we ascertained within our Dagestan Genetic Heritage Research Project. The results obtained support the notion that mapping genes of any complex disease (e.g., schizophrenia) in demographically older genetic isolates may be more time and cost effective due to their high clinical and genetic homogeneity, in comparison with demographically younger isolates, especially with genetically heterogeneous outbred populations.
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