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Drug Design and Discovery in Alzheimer`s Disease, Atta-ur-Rahman


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Автор: Atta-ur-Rahman
Название:  Drug Design and Discovery in Alzheimer`s Disease
ISBN: 9780128039595
Издательство: Elsevier Science
Классификация:



ISBN-10: 0128039590
Обложка/Формат: Paperback
Страницы: 784
Вес: 1.56 кг.
Дата издания: 03.06.2015
Язык: English
Размер: 190 x 233 x 32
Читательская аудитория: Professional & vocational
Ссылка на Издательство: Link
Рейтинг:
Поставляется из: Европейский союз
Описание:

Drug Design and Discovery in Alzheimers Disease includes expert reviews of recent developments in Alzheimers disease (AD) and neurodegenerative disease research. Originally published by Bentham as Frontiers in Drug Design and Discovery, Volume 6and now distributed by Elsevier, this compilation of the sixteen articles, written by leading global researchers, focuses on key developments in the understanding of the disease at molecular levels, identification and validation of molecular targets, as well as innovative approaches towards drug discovery, development, and delivery. Beginning with an overview of AD pharmacotherapy and existing blockbuster drugs, the reviews cover the potential of both natural and synthetic small molecules; the role of cholinesterases in the on-set and progression of AD and their inhibition; the role of beta-site APP clearing enzyme-1 (BACE-1) in the production of -amyloid proteins, one of the key reasons of the progression of AD; and other targets identified for AD drug discovery.

  • Edited and written by leading experts in Alzheimers disease (AD) and other neurodegenerative disease drug development
  • Describes existing drugs for AD and current molecular understanding of the condition
  • Reviews recent advances in the field, including coverage of cholinesterases, BACE-1, and other drug development targets


Proteomic and Metabolomic Approaches to Biomarker Discovery,

Автор: Haleem J. Issaq
Название: Proteomic and Metabolomic Approaches to Biomarker Discovery,
ISBN: 0123944465 ISBN-13(EAN): 9780123944467
Издательство: Elsevier Science
Цена: 115940.00 T
Наличие на складе: Невозможна поставка.
Описание: Proteomic and Metabolomic Approaches to Biomarker Discovery demonstrates how to leverage biomarkers to improve accuracy and reduce errors in research. Disease biomarker discovery is one of the most vibrant and important areas of research today, as the identification of reliable biomarkers has an enormous impact on disease diagnosis, selection of treatment regimens, and therapeutic monitoring. Various techniques are used in the biomarker discovery process, including techniques used in proteomics, the study of the proteins that make up an organism, and metabolomics, the study of chemical fingerprints created from cellular processes. . Proteomic and Metabolomic Approaches to Biomarker Discovery is the only publication that covers techniques from both proteomics and metabolomics and includes all steps involved in biomarker discovery, from study design to study execution. The book describes methods, and presents a standard operating procedure for sample selection, preparation, and storage, as well as data analysis and modeling. This new standard effectively eliminates the differing methodologies used in studies and creates a unified approach. Readers will learn the advantages and disadvantages of the various techniques discussed, as well as potential difficulties inherent to all steps in the biomarker discovery process. A vital resource for biochemists, biologists, analytical chemists, bioanalytical chemists, clinical and medical technicians, researchers in pharmaceuticals, and graduate students, Proteomic and Metabolomic Approaches to Biomarker Discovery provides the information needed to reduce clinical error in the execution of research.


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