Epigenetic Biomarkers and Diagnostics, Jose Luis Garcia-Gimenez
Автор: Rozlosnik N. Название: Nanomedicine in Diagnostics ISBN: 1578087384 ISBN-13(EAN): 9781578087389 Издательство: Taylor&Francis Рейтинг: Цена: 103610.00 T Наличие на складе: Есть Описание: Research on new sensing concepts has opened the door to a wide variety of microsystems for clinical applications. Such devices are extremely useful for delivering diagnostic information in a fast, simple, and low cost fashion. This book is one of the first to focus on the use of nanotechnology in diagnostics. Designed as a broad survey of the field, this book combines contributions by international experts from divergent fields of study ranging from single molecule diagnostics to cell based systems.
Автор: Jain K.K. Название: The Handbook of biomarkers ISBN: 160761684X ISBN-13(EAN): 9781607616849 Издательство: Springer Рейтинг: Цена: 174150.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This handbook describes many different types of biomarkers and their discovery. It also presents the background information needed for the evaluation of biomarkers as well as the essential procedures for their validation and use in clinical trials.
Автор: Cornelis Murre Название: Epigenetic Regulation of Lymphocyte Development ISBN: 3642447678 ISBN-13(EAN): 9783642447679 Издательство: Springer Рейтинг: Цена: 213360.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The studies described in this volume serve as a starting point to familiarize one self with the multifarious differences in epigenetic designs that orchestrate the progression of developing blood cells. They also may serve as a general paradigm for the mechanisms that underpin the control of eukaryotic gene expression.
Автор: L?bbert Название: Epigenetic Therapy of Cancer ISBN: 364238403X ISBN-13(EAN): 9783642384035 Издательство: Springer Рейтинг: Цена: 153720.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book covers the translation of basic research and drug development to clinical applications in the treatment of solid tumors as well as hematologic malignancies and hemoglobinopathy. It examines both present and future clinical strategies.
Автор: Suming Huang Название: Epigenetic Gene Expression and Regulation ISBN: 0127999582 ISBN-13(EAN): 9780127999586 Издательство: Elsevier Science Рейтинг: Цена: 108920.00 T Наличие на складе: Невозможна поставка. Описание:
Epigenetic Gene Expression and Regulation reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies.
The book shows how these heritable mechanisms allow individual cells to establish stable and unique patterns of gene expression that can be passed through cell divisions without DNA mutations, thereby establishing how different heritable patterns of gene regulation control cell differentiation and organogenesis, resulting in a distinct human organism with a variety of differing cellular functions and tissues.
The work begins with basic biology, encompasses methods, cellular and tissue organization, topical issues in epigenetic evolution and environmental epigenesis, and lastly clinical disease discovery and treatment.
Each highly illustrated chapter is organized to briefly summarize current research, provide appropriate pedagogical guidance, pertinent methods, relevant model organisms, and clinical examples.
Название: Handbook of Therapeutic Biomarkers in Cancer ISBN: 9814364657 ISBN-13(EAN): 9789814364652 Издательство: Taylor&Francis Рейтинг: Цена: 142910.00 T Наличие на складе: Поставка под заказ. Описание: In this volume, a team of internationally recognized experts provide an in-depth description of therapeutic biomarkers across a broad area of cancer research and oncology. With a wealth of information to specific therapies, each chapter focuses on a class of targeted chemotherapy agents. The book describes established and evolving diagnostic tests for therapeutic biomarkers that predict benefit, response, resistance, or drug side effects from specific therapeutic interventions. This volume is an essential handbook for health professionals and scientists researching current applicable biomarkers in oncology.
Автор: Trygve Tollefsbol Название: Handbook of Epigenetics, ISBN: 0123757096 ISBN-13(EAN): 9780123757098 Издательство: Elsevier Science Рейтинг: Цена: 128710.00 T Наличие на складе: Поставка под заказ. Описание:
Epigenetics is considered by many to be the "new genetics" because of the overwhelming evidence of the contribution of non-genetic factors such as nutrition, environment, and chemical exposure on gene expression. The effects of epigenetics are vast, including tissue/organ regeneration, X-chromosome inactivation, and stem cell differentiation and genomic imprinting and aging. Aberrations of epigenetics influence many diseases for which clinical intervention is already in place, and many novel epigenetic therapies for cancer, immune disorders, neurological and metabolic disorders, and imprinting diseases are on the horizon.
This comprehensive collection of reviews written by leaders in the field of epigenetics provides a broad view of this important and evolving topic. From molecular mechanisms and epigenetic technology to discoveries in human disease and clinical epigenetics, the nature and applications of the science will be presented for those with interests ranging from the fundamental basis of epigenetics to therapeutic interventions for epigenetic-based disorders.
Contributions by leading international investigators involved in molecular research and clinical and therapeutic applications
Integrates methods and biological topics with basic and clinical discoveries
Includes coverage of new topics in epigenetics such as prions, regulation of long-term memory by epigenetics, metabolic aspects of epigenetics, and epigenetics of neuronal disorders
Автор: Val?rie Taly; Jean-Louis Viovy; St?phanie Descroix Название: Microchip Diagnostics ISBN: 1493967320 ISBN-13(EAN): 9781493967322 Издательство: Springer Рейтинг: Цена: 102480.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
Microfluidics-enabled Diagnostic Systems: Markets, Challenges, and Examples.- Capillary-Driven Microfluidic Chips for Miniaturized Immunoassays: Efficient Fabrication and Sealing of Chips Using a "Chip-olate" Process.- Capillary-driven Microfluidic Chips for Miniaturized Immunoassays: Patterning Capture Antibodies using Microcontact Printing and Dry-film Resists.- Fabrication and Evaluation of Microfluidic Immunoassay Devices with Antibody-immobilized Microbeads Retained in Porous Hydrogel Micropillars.- Using Electrophoretic Immunoassay to Monitor Hormone Secretion.- On-chip Magnetic Particle-based Immunoassays using Multilaminar Flow for Clinical Diagnostic.- Digital Microfluidics Assisted Sealing of Individual Magnetic Particles in fFmtoliter-sized Reaction wells for Single-molecule Detection.- Microfluidic DNA Stretching Device for Single-Molecule Diagnostics.- Droplet Microfluidic and Magnetic Particles Platform for Cancer Typing.- SlipChip Device for Digital Nucleic Acid Amplification.- Multiplex Detection of KRAS Mutations using Passive Droplet Fusion.- Droplet-based Microfluidics Digital PCR for the Detection of KRAS Mutations.- Negative Enrichment of Circulating Tumor Cells in Blood Using a Microfluidic Chip.- Microfluidic Based Bacteria Isolation from Whole Blood for Diagnostics of Blood Stream Infection.- Microfluidic POlatform for Parallel Single Cell Analysis for Diagnostic Applications.- FISH-in-CHIPS.
Автор: George Patrinos Название: Molecular Diagnostics, ISBN: 0125466617 ISBN-13(EAN): 9780125466615 Издательство: Elsevier Science Рейтинг: Цена: 99930.00 T Наличие на складе: Невозможна поставка. Описание: Covers the molecular biological techniques used to identify the underlying molecular defects in inherited disease. This book features chapters which include the principle and a brief description of the technique. It also includes techniques for the detection of the underlying genetic heterogeneity leading to inherited disorders.
Автор: Nakamura Название: Cancer Diagnostics. 2004 ISBN: 1588291677 ISBN-13(EAN): 9781588291677 Издательство: Springer Рейтинг: Цена: 213360.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: offers a review of the considerable advances in technology during the past several years; the authors were concerned primarily with clinical laboratory tests; these tests may already, or in the near future, help in the early detection, evaluation, and prediction of human tumors for specific therapeutic decisions.
Автор: Patrinos, George Название: Molecular Diagnostics ISBN: 0128029714 ISBN-13(EAN): 9780128029718 Издательство: Elsevier Science Рейтинг: Цена: 123520.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
Molecular Diagnostics, Third Edition, focuses on the technologies and applications that professionals need to work in, develop, and manage a clinical diagnostic laboratory. Each chapter contains an expert introduction to each subject that is next to technical details and many applications for molecular genetic testing that can be found in comprehensive reference lists at the end of each chapter.
Contents are divided into three parts, technologies, application of those technologies, and related issues. The first part is dedicated to the battery of the most widely used molecular pathology techniques. New chapters have been added, including the various new technologies involved in next-generation sequencing (mutation detection, gene expression, etc.), mass spectrometry, and protein-specific methodologies.
All revised chapters have been completely updated, to include not only technology innovations, but also novel diagnostic applications. As with previous editions, each of the chapters in this section includes a brief description of the technique followed by examples from the area of expertise from the selected contributor.
The second part of the book attempts to integrate previously analyzed technologies into the different aspects of molecular diagnostics, such as identification of genetically modified organisms, stem cells, pharmacogenomics, modern forensic science, molecular microbiology, and genetic diagnosis. Part three focuses on various everyday issues in a diagnostic laboratory, from genetic counseling and related ethical and psychological issues, to safety and quality management.
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