Gene Therapy for Viral Infections, Patrick Arbuthnot

Автор: Giacca Mauro
Название: Gene Therapy
ISBN: 8847016428 ISBN-13(EAN): 9788847016422
Издательство: Springer
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Цена: 78250.00 T
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Описание: Gene Therapy presents a comprehensive overview of the field, ranging from vector development and therapeutic gene selection to the results of the most recent clinical trials. Written in a clear, didactic style, the volume makes gene therapy methods easily accessible to readers.

Автор: Escors
Название: Lentiviral Vectors and Gene Therapy
ISBN: 3034804016 ISBN-13(EAN): 9783034804011
Издательство: Springer
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Цена: 60940.00 T
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Описание: Gene therapy was conceived during the early and mid part of the 20th century. At first, it was considered a revolutionary biomedical procedure, which could potentially cure any disease for which the molecular bases were understood. Since then, gene therapy has gone through many stages and has evolved from a nearly unrealistic perspective to a real life application. Clinical efficacy in humans was demonstrated at the beginning of this century after its successful application in small-scale clinical trials to cure severe immunodeficiency in children. However, their successes were overshadowed some time later by the occurrence of vector-related leukaemia in a number of treated children. It is in this context that lentiviral vectors have appeared, with improved efficiency and, possibly, increased biosafety. Very recently, the first clinical trials with lentivectors have been carried out with some success. This Brief firstly defines gene therapy, and places lentivectors within this fascinating therapeutic strategy. Then follows a comprehensive description of the development of retroviral and lentiviral vectors and how to specifically target distinct cell types and tissues. The authors also discuss the application of lentivector gene therapy for the treatment of cancer and autoimmune diseases, ending with the application of lentivectors in human gene therapy clinical trials.

Автор: LeDoux, Joseph (Ed.)
Название: Gene therapy protocols: Volume 1 preliminary entry 2071 production and in vivo applications of gene transfer vectors
ISBN: 1588299031 ISBN-13(EAN): 9781588299031
Издательство: Springer
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Цена: 135090.00 T
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Описание: Describes methods for the production of viral and non-viral gene transfer vectors, as well as protocols for critical applications in stem cell biology, cancer, diabetes, HIV and tissue engineering.

Автор: Edmund C. Lattime
Название: Gene Therapy of Cancer,
ISBN: 0123942950 ISBN-13(EAN): 9780123942951
Издательство: Elsevier Science
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Цена: 154960.00 T
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Описание: Gene therapy as a treatment for cancer is at a critical point in its evolution. This book offers a comprehensive assessment of the field including the areas of suicide gene therapy, oncogene and suppressor gene targeting, immunotherapy, drug resistance gene therapy, and the genetic modification of stem cells.

Автор: Wolfgang Walther
Название: Current Strategies in Cancer Gene Therapy
ISBN: 3319429329 ISBN-13(EAN): 9783319429328
Издательство: Springer
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Цена: 130430.00 T
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Описание: This book describes important developments and emerging trends in experimental and clinical cancer gene therapy. It reflects the tremendous advances made over recent years with respect to immunogenes, suicide genes and gene correction therapies, as well as in gene suppression and miRNA therapies.

Автор: Candiani
Название: Non-Viral Gene Delivery Vectors
ISBN: 1493937162 ISBN-13(EAN): 9781493937165
Издательство: Springer
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Цена: 130430.00 T
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Описание: This volume provides readers with a wide collection of the latest and readily reproducible technical protocols available in the field ofnon-viral gene delivery vectors. The chapters in this book are organized intothree major parts: Part I is a section on conventional bolus gene deliveryvectors that introduces typical transfection approaches relyingon the addition of transfectants to the cell culture medium where the cells aregrown in; Part II covers stimuli-responsive bolus transfectants and topics on gene delivery complexes made of smart polymers orstimuli-responsive polymers that change according to the environment they arein and delivered by dripping into cells; Part III discusses examples ofsubstrate-mediated gene delivery—also termed reversetransfection—and the immobilization of a gene delivery vector onto a surface asopposed to more typical bolus delivery from the medium. Written in the highlysuccessful Methods in Molecular Biology series format, chapters includeintroductions to their respective topics, lists of the necessary materials andreagents, step-by-step, readily reproducible laboratory protocols, and tips ontroubleshooting and avoiding known pitfalls.Cutting-edge and practical, Non-Viral Gene Delivery Vectors: Methods andProtocols is written for experimentalists, and is an essential part of manylaboratory bookshelves. This book will help novice and professionals alikesucceed in their research in this field.

Автор: Merten
Название: Viral Vectors for Gene Therapy
ISBN: 161779094X ISBN-13(EAN): 9781617790942
Издательство: Springer
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Цена: 149060.00 T
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Описание: The huge potential for gene therapy to cure a wide range of diseases has led to high expectations and a great increase in research efforts in this area, particularly in the study of delivery via viral vectors, widely considered to be more efficient than DNA transfection.  In Viral Vectors for Gene Therapy: Methods and Protocols, experts in the field present a collection of their knowledge and experience featuring methodologies that involve virus production, transferring protocols, and evaluating the efficacy of gene products. While thoroughly covering the most popular viral vector systems of adenovirus, retrovirus, and adeno-associated virus, this detailed volume also explores less common viral vector systems such as baculovirus, herpes virus, and measles virus, the growing interest in which is creating a considerable demand for large scale manufacturing and purification procedures.  Written in the highly successful Methods in Molecular Biology™ series format, many chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and vital tips on troubleshooting and avoiding known pitfalls. Comprehensive and practical, Viral Vectors for Gene Therapy: Methods and Protocols provides basic principles accessible to scientists from a wide variety of backgrounds for the development of gene therapy viral products that are safe and effective.

Автор: Schleef
Название: Minicircle and Miniplasmid DNA Vectors: The Future of Non-viral and Viral Gene Transfer
ISBN: 3527324569 ISBN-13(EAN): 9783527324569
Издательство: Wiley
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Цена: 97100.00 T
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Описание: * Covers a new approach to gene therapy with a greatly improved safety profile * Complete coverage of the topic including molecular basis, production and biomedical applications * Has a wide audience including everyone who is directly or indirectly involved in the development of gene therapies .

Автор: LeDoux, Joseph (Ed.)
Название: Gene therapy protocols: Vol 2 design and characterization of gene transfer vectors
ISBN: 160327247X ISBN-13(EAN): 9781603272476
Издательство: Springer
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Цена: 158380.00 T
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Описание: The field of gene therapy has undergone remarkable advances, promising to impact human healthcare in the 21st century. This book provides methods for the processing and characterization of viral and non-viral gene transfer vectors, as well as promising approaches to design vectors for efficient, targeted and regulated gene delivery and expression.