Handbook of Methods for Designing, Monitoring, and Analyzing Dose-Finding Trials,
Автор: John O`Quigley, Alexia Iasonos, Bjorn Bornkamp Название: Handbook of Methods for Designing, Monitoring, and Analyzing Dose-Finding Trials ISBN: 0367330687 ISBN-13(EAN): 9780367330682 Издательство: Taylor&Francis Рейтинг: Цена: 76550.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This handbook provides an overview of up-to-date statistical methods required for design, monitoring and analysis for dose finding clinical trials, focusing both on the clinical aspects as well as statistical considerations. This book will not cover statistical methods for Phase II non-dose finding studies or Phase III clinical trials.
Автор: Takashi Daimon; Akihiro Hirakawa; Shigeyuki Matsui Название: An Introduction to Dose-Finding Methods in Early Phase Clinical Trials ISBN: 4431555846 ISBN-13(EAN): 9784431555841 Издательство: Springer Рейтинг: Цена: 46570.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Included are rule-based and model-based designs, such as 3 + 3 designs, accelerated titration designs, toxicity probability interval designs, continual reassessment method and related designs, and escalation overdose control designs.
Автор: Wolfgang von der Linden; Volker Dose; Rainer Fisch Название: Maximum Entropy and Bayesian Methods Garching, Germany 1998 ISBN: 9401059829 ISBN-13(EAN): 9789401059824 Издательство: Springer Рейтинг: Цена: 139750.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Proceedings of the 18th International Workshop on Maximum Entropy and Bayesian Methods of Statistical Analysis
Автор: Wolfgang von der Linden; Volker Dose; Rainer Fisch Название: Maximum Entropy and Bayesian Methods Garching, Germany 1998 ISBN: 0792357663 ISBN-13(EAN): 9780792357667 Издательство: Springer Рейтинг: Цена: 181630.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Taken from the 1998 MaxEnt conference, this work contains a range of applications of Bayesian probability theory and maximum entropy methods to problems of concern in such fields as physics, image processing, coding theory, machine learning, economics, data analysis and various other problems.
Автор: Tallarida, Ronald J. Название: Drug Synergism and Dose-Effect Data Analysis ISBN: 0367398346 ISBN-13(EAN): 9780367398347 Издательство: Taylor&Francis Рейтинг: Цена: 65320.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
Not since this author's bestselling Manual of Pharmacologic Calculation-long out of print-has there been a reference available for drug data analysis, and even that work did not deal with drug combinations. Although pharmacologists and most other scientists know what synergism is, mainstream textbooks tend to neglect it as a quantitative topic. Few researchers are familiar with the quantitative methodology needed to differentiate synergistic responses from the simply additive responses expected from drug combinations or a single drug's interaction with endogenous chemicals.
In Drug Synergism and Dose-Effect Data Analysis, noted pharmacologist, mathematician, and author Ronald J. Tallarida finally brings these methods to light. Drawing on statistical theory and methods but keeping the special needs of the pharmacologist in mind, he begins his treatment with dose-response relations, the statistical analysis of the data, and the models that describe them. He also offers the only modern presentation of probit and logit analysis and provides detailed calculation methods not found in typical statistics books. Numerous examples accompany a presentation that clearly illustrates the calculations and experimental design considerations for modern drug analysis. You'll find the conceptual background, the algorithms, and new research developments. In short, Drug Synergism and Dose-Effect Data Analysis has everything you need to perform, with confidence, the quantitative analysis of dose response data.
Автор: Naitee Ting Название: Dose Finding in Drug Development ISBN: 144192115X ISBN-13(EAN): 9781441921154 Издательство: Springer Рейтинг: Цена: 139310.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: If you have ever wondered when visiting the pharmacy how the dosage of your prescription is determined this book will answer your questions. It introduces the drug development process and explains the practical concerns in selecting doses for a new drug.
Автор: Cheung, Ying Kuen Название: Dose Finding by the Continual Reassessment Method ISBN: 1420091514 ISBN-13(EAN): 9781420091519 Издательство: Taylor&Francis Рейтинг: Цена: 163330.00 T Наличие на складе: Поставка под заказ.
Автор: Hempel, Georg Название: Methods of Therapeutic Drug Monitoring including Pharmacogenetics ISBN: 0444640665 ISBN-13(EAN): 9780444640666 Издательство: Elsevier Science Рейтинг: Цена: 196510.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
Methods of Therapeutic Drug Monitoring including Pharmacogenetics, Second Edition, the 6th volume in the Handbook of Analytical Separations series, covers all aspects of drug monitoring including laboratory work, pharmacokinetic analysis, and clinical aspects. This enables readers from different fields--from the physician on the ward to the analytical chemist--to understand the whole process of therapeutic drug monitoring and to avoid common pitfalls which can arise in all steps of the process.
The new edition contains updated information on analytical techniques for the quantification of drugs as well as pharmacogenetic and pharmacogenomic methods. Recent improvements in column technology for liquid chromatography are covered, as is the use of mass spectroscopy as a detector for all chargeable compounds, which is becoming affordable for many laboratories. Also included are updates on sample preparation, including dried blood spot technology and microextraction methods. Coverage has been expanded to drugs new to the market, such as tyrosine kinase inhibitors in oncology and the monitoring of immunosuppressant drugs. The chapter on pharmacokinetic methods is also now streamlined to focus on the applied statistical methods in order to clearly explain the procedures and possible pitfalls.
Unique interdisciplinary approach appeals to a wide range of users, ensuring more successful drug monitoring applications in a number of clinical environments
Each chapter is written by an author from an international lab, providing a global perspective that can be applied in various regulatory environments
Features additional therapeutic drugs to reflect the rising number of immunocompromised patients
Includes a new mass spectroscopic methods chapter to capture the frequent use in TDM and the improved availability of LC-MS across laboratories
Автор: Moore Elaine A., Wilkinson Samantha Название: The Promise of Low Dose Naltrexone Therapy: Potential Benefits in Cancer, Autoimmune, Neurological and Infectious Disorders ISBN: 0786437154 ISBN-13(EAN): 9780786437153 Издательство: Mare Nostrum (Eurospan) Рейтинг: Цена: 20900.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Naltrexone is an opiate antagonist drug developed in the 1970s and approved by the FDA in 1984 as a safe and effective treatment for opiate and drug abuse. This book describes the history of naltrexone, including its potential therapeutic uses, its effects on the immune system, and its pharmacological properties.
Автор: Ritz, Christian (University of Copenhagen, Denmark) Jensen, Signe Marie (University of Copenhagen, Denmark) Gerhard, Daniel Streibig, Jens Carl Название: Dose-Response Analysis Using R ISBN: 1032091819 ISBN-13(EAN): 9781032091815 Издательство: Taylor&Francis Рейтинг: Цена: 50010.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Dose-response analysis is a technique used to determine the safe and hazardous dosage of drugs, pollutants, and other substances to which humans and other organisms are exposed. This book provides a practical and comprehensive overview of methods for dose-response analysis.
Автор: Williams Ph.D., Lawrence Название: Radiopharmaceuticals ISBN: 0367577054 ISBN-13(EAN): 9780367577056 Издательство: Taylor&Francis Рейтинг: Цена: 48990.00 T Наличие на складе: Есть у поставщика Поставка под заказ.
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