Nuclear Pore Complexes And Nucleocytoplasmic Transport - Methods,122, Doye,Valerie
Автор: Paul S. Agutter; Philip L. Taylor Название: The Meaning of Nucleocytoplasmic Transport ISBN: 3662225042 ISBN-13(EAN): 9783662225042 Издательство: Springer Рейтинг: Цена: 46570.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: However, the authors challenge the presumptions implicit in some interpretations of the evidence, re-examining the concept of "transport" within cells, and suggesting that lessons learned from nucleocytoplasmic transport studies can elucidate wider aspects of cell biology.
Автор: Reiner Peters; Michael Trendelenburg Название: Nucleocytoplasmic Transport ISBN: 3642715672 ISBN-13(EAN): 9783642715679 Издательство: Springer Рейтинг: Цена: 102480.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The exchange of information and matter between cell nucleus and cyto- plasm is an intriguing aspect of the eukaryotic cell which has attrac- ted the cell biologists' attention for many decades. Nevertheless, the elucidation of nucleocytoplasmic transport is still in a stage where questions can be more easily formulated than answered. Considering the explosive progress in molecular biology, the somewhat prodromal stage of nucleocytoplasmic transport studies may seem astonishing. However, the situation becomes immediately intelligible if technical aspects are taken into consideration. Nucleocytoplasmic transport is a func- tion of the living cell and the development of suitable in-vitro sys- tems proved to be difficult. Recently, novel techniques for measuring molecular transport in single cells have been developed. Substantial proqress has been also achieved by gene technology. In this situation a 'Workshop on Nucleocytoplasmic Transport' was held at the Deutsches Krebsforschungszentrum (German Cancer Research Center), Heidelberg, Federal Republic of Germany. A brief yet essentially complete picture of the field and its prospects was sought. The present book contains the proceedings of this work- shop. The book is organized in the following manner: - Historical dimensions of the field are illuminated by Brachet. - Techniques for single-cell studies are reported by Engelhardt et al., Garland & Birmingham, Krafft et al., Feldherr, Neuhaus & Schweiger, Riedel et al., Edstrom, and Trendelenburg et al .. - The structure and biochemistry of the nuclear envelope is discussed by Milligan, Maul & Schatten, Krohne & Benavente, and Dreyer et al ..
The three-dimensional organization of the DNA inside the eukaryotic cell nucleus has emerged a critical regulator of genome integrity and function. Increasing evidence indicates that nuclear pore complexes (NPCs), the large protein channels that connect the nucleus to the cytoplasm, play a critical role in the establishment and maintenance of chromatin organization and in the regulation of gene activity. These findings, which oppose the traditional view of NPCs as channels with only one: the facilitation of nucleocytoplasmic molecule exchange, have completely transformed our understanding of these structures. This book describes our current knowledge of the role of NPCs in genome organization and gene expression regulation. It starts by providing an overview of the different compartments and structures of the nucleus and how they contribute to organizing the genome, then moves to examine the direct roles of NPCs and their components in gene expression regulation in different organisms, and ends by describing the function of nuclear pores in the infection and genome integration of HIV, in DNA repair and telomere maintenance, and in the regulation of chromosome segregation and mitosis. This book provides an intellectual backdrop for anyone interested in understanding how the gatekeepers of the nucleus contribute to safeguarding the integrity and function of the eukaryotic genome.
Автор: D`Angelo Название: Nuclear Pore Complexes in Genome Organization, Function and Maintenance ISBN: 3319716123 ISBN-13(EAN): 9783319716121 Издательство: Springer Рейтинг: Цена: 139750.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The three-dimensional organization of the DNA inside the eukaryotic cell nucleus has emerged a critical regulator of genome integrity and function. Increasing evidence indicates that nuclear pore complexes (NPCs), the large protein channels that connect the nucleus to the cytoplasm, play a critical role in the establishment and maintenance of chromatin organization and in the regulation of gene activity. These findings, which oppose the traditional view of NPCs as channels with only one: the facilitation of nucleocytoplasmic molecule exchange, have completely transformed our understanding of these structures.
This book describes our current knowledge of the role of NPCs in genome organization and gene expression regulation. It starts by providing an overview of the different compartments and structures of the nucleus and how they contribute to organizing the genome, then moves to examine the direct roles of NPCs and their components in gene expression regulation in different organisms, and ends by describing the function of nuclear pores in the infection and genome integration of HIV, in DNA repair and telomere maintenance, and in the regulation of chromosome segregation and mitosis. This book provides an intellectual backdrop for anyone interested in understanding how the gatekeepers of the nucleus contribute to safeguarding the integrity and function of the eukaryotic genome.
Автор: Goldberg Martin W. Название: The Nuclear Pore Complex: Methods and Protocols ISBN: 1071623362 ISBN-13(EAN): 9781071623367 Издательство: Springer Рейтинг: Цена: 186330.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This volume covers all methods used to discover the composition, structure, and dynamics of the nuclear pore complex (NPC), as well as the soluble transport factors involved in the transport process.
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