Автор: Ferguson, Bradley Название: Ferguson-NUTRITIONAL EPIGENOMICS ISBN: 0128168439 ISBN-13(EAN): 9780128168431 Издательство: Elsevier Science Рейтинг: Цена: 176290.00 T Наличие на складе: Нет в наличии. Описание:
Nutritional Epigenomics offers a comprehensive overview of nutritional epigenomics as a mode of study, along with nutrition's role in the epigenomic regulation of disease, health and developmental processes. Here, an expert team of international contributors introduces readers to nutritional epigenomic regulators of gene expression, our diet's role in epigenomic regulation of disease and disease inheritance, caloric restriction and exercise as they relate to recent epigenomic findings, and the influence of nutritional epigenomics over circadian rhythms, aging and longevity, and fetal health and development, among other processes. Disease specific chapters address metabolic disease (obesity and diabetes), cancer, and neurodegeneration, among other disorders.
Diet-gut microbiome interactions in the epigenomic regulation of disease are also discussed, as is the role of micronutrients and milk miRNAs in epigenetic regulation. Finally, chapter authors examine ongoing discussions of race and ethnicity in the social-epigenomic regulation of health and disease.
Empowers the reader to employ nutritional epigenomics approaches in their own research
Discusses the latest topics in nutritional epigenomics in the regulation of aging, circadian rhythm, inheritance and fetal development, as well as metabolism and disease
Offers a full grounding in epigenetic reprogramming and nutritional intervention in the treatment and prevention of disease, as informed by population-based studies
Автор: Naumova Anna K & Taketo-Hosotani Teruko Название: Epigenetics In Human Reproduction And Development ISBN: 9813144262 ISBN-13(EAN): 9789813144262 Издательство: World Scientific Publishing Цена: 121440.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
Epigenetics is defined as heritable changes that do not affect the DNA sequence but influence gene expression. Epigenetic changes occur at the levels of DNA, histone, protein, and chromatin structures. Proper epigenetic modifications are essential for cell differentiation and function during development, while some epigenetic modifications are passed on from parents to offspring through gametes. Therefore, alterations of epigenetic states would have serious consequences for human development and health. This realization and the advent of new technologies have encouraged the advance of epigenetic studies in recent years. Nonetheless, many aspects of epigenetics, such as regulatory mechanisms and evolutional advantages, remain to be better understood.
Written by 26 scientists at the forefront of epigenetics research, this book discusses the different facets of epigenetics: from gametogenesis to child development, as well as from mechanistic studies in animal models to reviews of human clinical data.
Автор: Johannes Backs, Timothy McKinsey Название: Epigenetics in Cardiac Disease ISBN: 3319414550 ISBN-13(EAN): 9783319414553 Издательство: Springer Рейтинг: Цена: 97820.00 T Наличие на складе: Нет в наличии. Описание: This book describes important advances in our understanding of how environmental conditions affect cardiac gene expression through epigenetic mechanisms. Further, it discusses the roles of chromatin modifications (in particular DNA methylation and histone modifications) and of chromatin regulators in the context of cardiac diseases. The book provides readers with an overview of our current understanding of epigenetic regulation in the heart, and will stimulate further research in this exciting field. Edited and written by internationally respected experts, it addresses the needs of professors, students and researchers working in the fields of cardiac biology and epigenetics.
Автор: Moskalev, Alexey Название: Epigenetics of Aging and Longevity ISBN: 0128110600 ISBN-13(EAN): 9780128110607 Издательство: Elsevier Science Рейтинг: Цена: 132500.00 T Наличие на складе: Нет в наличии. Описание:
Epigenetics of Aging and Longevity provides an in-depth analysis of the epigenetic nature of aging and the role of epigenetic factors in mediating the link between early-life experiences and life-course health and aging. Chapters from leading international contributors explore the effect of adverse conditions in early-life that may result in disrupted epigenetic pathways, as well as the potential to correct these disrupted pathways via targeted therapeutic interventions. Intergenerational epigenetic inheritance, epigenetic drug discovery, and the role of epigenetic mechanisms in regulating specific age-associated illnesses--including cancer and cardiovascular, metabolic, and neurodegenerative diseases--are explored in detail.
This book will help researchers in genomic medicine, epigenetics, and biogerontology better understand the epigenetic determinants of aging and longevity, and ultimately aid in developing therapeutics to extend the human life-span and treat age-related disease.
Автор: Rodrick Wallace Название: Computational Psychiatry ISBN: 3319539094 ISBN-13(EAN): 9783319539096 Издательство: Springer Рейтинг: Цена: 139750.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book explores mental disorders from a uniquely evolutionary perspective.
Автор: L. Joseph Su; Tung-chin Chiang Название: Environmental Epigenetics ISBN: 1447166779 ISBN-13(EAN): 9781447166771 Издательство: Springer Рейтинг: Цена: 158380.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: What is Epigenetics.- Epidemiology of environment and health.- Technologies in measuring epigenetics.- Epigenetic changes in hormone related disease.- Epigenetic effects of environmental chemicals bisphenol a and phthalates.- Environmental epigenetics: a role in endocrine diseases?.- Pregnancy exposures determine risk of breast cancer in multiple generations of offspring.- Environmental epigenetics and obesity - evidences from animal to epidemiologic studies.- Environmental toxicants, epigenetics and cancer.- Aging, genes, environment and epigenetics.- Epigenetics: The link between nature and nurture.- Gene-Environment Interactions in Human Health.- Environmental epigenetics: prospects for studying epigenetic mediation of exposure-response relationships.- Conclusions: Lessons from epigenetic research: the impact of environmental stress can be accumulated and resulted in diverse outcome.
Автор: Tollefsbol, Trygve Название: Epigenetics And Reproductive Health ISBN: 0128197536 ISBN-13(EAN): 9780128197530 Издательство: Elsevier Science Рейтинг: Цена: 153830.00 T Наличие на складе: Нет в наличии. Описание:
Epigenetics and Reproductive Health, a new volume in the Translational Epigenetics series, provides a thorough overview and discussion of epigenetics in reproduction and implications for reproductive medicine. Twenty international researchers discuss epigenetic mechanisms operating during the formation of male and female gametes, fertilization and subsequent embryo and placental development, particularly in mammals and transgenerational epigenetic inheritance. This volume also addresses aberrant epigenetic changes influencing male and female infertility, pregnancy related disorders, and those potentially linked to therapeutic manipulations and assisted reproductive technologies. Emphasis is placed on identifying biomarkers for early detection of aberrant epigenetic mechanisms.
Later chapters examine the possibility of correcting these epigenetic dysfunctions, as well as current challenges and next steps in research, enabling new translational discoveries and efforts towards developing therapeutics.
Автор: Arturas Petronis; Jonathan Mill Название: Brain, Behavior and Epigenetics ISBN: 3642268323 ISBN-13(EAN): 9783642268328 Издательство: Springer Рейтинг: Цена: 191550.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Epigenetics, once believed stable after development, has been found to occur in fully differentiated, post-mitotic central nervous system cells in response to environmental signals. This book explores the role of epigenetic risk factors in complex diseases.
Автор: Trygve O. Tollefsbol Название: Epigenetics Protocols ISBN: 149396187X ISBN-13(EAN): 9781493961870 Издательство: Springer Рейтинг: Цена: 135090.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Focusing on the two broad areas of epigenetics, DNA methylation and chromatin modifications, this book highlights select techniques that have been mainstays in the field. It also covers methods especially relevant to extant discoveries in epigenetics.
Автор: Navakauskien˙e RЇuta, Navakauskas Dalius, Borutinskait˙e Veronika Название: Epigenetics and Proteomics of Leukemia: A Synergy of Experimental Biology and Computational Informatics ISBN: 3030687074 ISBN-13(EAN): 9783030687076 Издательство: Springer Цена: 158380.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book reviews the current state of epigenetics and proteomics of leukemia and introduces the methods that are important to process and evaluate these factors in leukemia.
Автор: Oscar J. Wambuguh Название: Examining the Causal Relationship Between Genes, Epigenetics, and Human Health ISBN: 1522580662 ISBN-13(EAN): 9781522580669 Издательство: Mare Nostrum (Eurospan) Рейтинг: Цена: 287370.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: For as much as we know about DNA and gene expression, many more mysteries remain to be solved. Epigenetics and epigenomics seek to study heritable modifications in gene expression that do not involve underlying DNA sequences to further human health changes. Examining the Causal Relationship Between Genes, Epigenetics, and Human Health provides innovative research methods and applications of chemical activation or deactivation of genes without altering the original DNA sequence. While highlighting topics including gene expression, personalized medicine, and public policy, this book is ideal for researchers, geneticists, biologists, medical professionals, students, and academics seeking current research on the expanding fields of genomics, epigenomics, proteomics, pharmacogenomics, and genome-wide association studies.
Автор: Provenzi, Livio Название: Developmental Human Behavioral Epigenetics ISBN: 0128192623 ISBN-13(EAN): 9780128192627 Издательство: Elsevier Science Рейтинг: Цена: 132500.00 T Наличие на складе: Нет в наличии. Описание:
Accumulating evidence suggests that environmentally-driven epigenetic regulation contributes to developmental phenotypes in humans. The panorama of human behavioral epigenetics research includes gene expression correlates of different environmental exposures, such as early-life adversities and protective care conditions.
Developmental Human Behavioral Epigenetics, a new volume in the Translational Epigenetics series, offers the first systematic account of theoretical frameworks, methodological approaches, findings, and future directions in the field of human behavioral epigenetics. Featuring contributions from leading scientists and international researchers, this book provides a comprehensive overview of human behavioral epigenetics, with a close examination of evidence gathered to-date from animal models, challenges of human-based research and clinical translation, pathways towards drug discovery, and next steps in research. Areas of focus include prenatal stress exposures, preterm behavioral epigenetics, intergenerational exposures, trauma and neglect, socio-economic conditions, maternal caregiving and attachment, study design, and epigenetics and psychotherapy.
Offering an interdisciplinary, scientifically rigorous but socially aware treatment, the book illuminates the molecular basis and implications of epigenetic mechanisms behind behavioral phenotypes, providing tools for population-based studies, and defining ethical pathways towards application in behavioral medicine.
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