Strategic Pharmaceutical Marketing Management in Growth Markets, Nandy, Mithun
Автор: Mithun Das, Kaushik Bose Название: Obesity and Syndrome X: A Global Public Health Burden ISBN: 1536146692 ISBN-13(EAN): 9781536146691 Издательство: Nova Science Рейтинг: Цена: 215410.00 T Наличие на складе: Невозможна поставка. Описание: Obesity is a major risk for both cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM). Obesity has reached epidemic proportions globally, and evidence suggests that the situation is likely to get worse in both developed and developing countries. It is considered to be a predisposing factor for several chronic diseases which include CVD, ischemic stroke, hypertension, T2DM, vascular dysfunction, and proinflammatory and prothrombotic state. This is where Syndrome X intersects with obesity and plays the role of a common denominator for CVD and T2DM. Persons with Syndrome X are more susceptible to CVD & T2DM.It is particularly relevant to recognize that variation in disease susceptibility among individuals in the population at large is a consequence of the intersection of the distribution of genotypes with the distribution of past environmental exposures and future environmental trajectories. For instance, many individuals who have a genotype that is found in those with disease will remain healthy because of the compensatory effects of a different environmental history on the same initial conditions. Similarly, individuals who do not have a high risk genotype may develop a disease of an adverse environmental history. That is, interaction between a particular genotype and particular environmental exposures.In the thrifty genotype hypothesis as proposed by Neel (1962), entire populations have an increased predisposition to T2DM due to genetic selection. They are better adapted to different nutritional circumstances than those they experience today. In the thrifty phenotype hypothesis (also known as Barkers Hypothesis), maladaptive responses occur as a result of environmentally induced alteration of physiology in the early life of the individual. Both hypotheses offer explanations of why the frequency of diabetes and obesity may differ in different populations and why predisposition to diabetes is common, albeit by very different mechanisms. A third hypothesis called the common soil hypothesis as mentioned by Lebovitz (2006) that diabetes and CVD might share an underlying cause(s) is also described. Insulin resistance is central both to the progression from normal glucose tolerance to T2DM and to a constellation of CVD risk factors known as Syndrome X or Metabolic Syndrome. Then there is the epigenome that directly impacts gene expression and can be modified by both genetic and environmental factors. It is the potentially heritable changes in gene expression that does not involve changes to the underlying DNA sequences a change in phenotype without a change in genotype. The epigenoytpe is dynamic and varies over time and tissues as a result of environmental exposure, aging, and diseases and other factors.The present book is an assembly of the vast knowledge that has been generated over the last decade worldwide in the field of obesity and metabolic syndrome related disorders, and an attempt to translate research findings into a clinically useful tool for better diagnosis, intervention, and prevention of this global public health burden. We hope this book will not only expand the practice in the coming years, but that it will create new avenues for future research as well.
Автор: Wolf Ned Название: Nandia`s Apparition: Book II of the Nandia Trilogy ISBN: 0967557569 ISBN-13(EAN): 9780967557564 Издательство: Неизвестно Рейтинг: Цена: 13750.00 T Наличие на складе: Невозможна поставка.
Автор: Nandy, Mithun Название: Strategic Pharmaceutical Marketing Management in Growth Markets ISBN: 1032289422 ISBN-13(EAN): 9781032289427 Издательство: Taylor&Francis Рейтинг: Цена: 137810.00 T Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Nandy Mithun Название: Relationship between R&D and Financial Performance in Indian Pharmaceutical Industry ISBN: 9811669201 ISBN-13(EAN): 9789811669200 Издательство: Springer Рейтинг: Цена: 102480.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The book provides insight into different research and development (R&D) activities performed by Indian pharmaceutical companies.
Автор: Campbell Lyle, Mithun Marianne Название: The Languages of Native America: Historical and Comparative Assessment ISBN: 0292768508 ISBN-13(EAN): 9780292768505 Издательство: Marston Book Services Цена: 97680.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: These essays were drawn from the papers presented at the Linguistic Society of America`s Summer Institute at the State University of New York at Oswego in 1976.
This handbook provides broad coverage of the languages indigenous to North America, with special focus on typologically interesting features and areal characteristics, surveys of current work, and topics of particular importance to communities. The volume is divided into two major parts: subfields of linguistics and family sketches. The subfields include those that are customarily addressed in discussions of North American languages (sounds and sound structure, words, sentences), as well as many that have received somewhat less attention until recently (tone, prosody, sociolinguistic variation, directives, information structure, discourse, meaning, language over space and time, conversation structure, evidentiality, pragmatics, verbal art, first and second language acquisition, archives, evolving notions of fieldwork). Family sketches cover major language families and isolates and highlight topics of special value to communities engaged in work on language maintenance, documentation, and revitalization.
This handbook provides broad coverage of the languages indigenous to North America, with special focus on typologically interesting features and areal characteristics, surveys of current work, and topics of particular importance to communities. The volume is divided into two major parts: subfields of linguistics and family sketches. The subfields include those that are customarily addressed in discussions of North American languages (sounds and sound structure, words, sentences), as well as many that have received somewhat less attention until recently (tone, prosody, sociolinguistic variation, directives, information structure, discourse, meaning, language over space and time, conversation structure, evidentiality, pragmatics, verbal art, first and second language acquisition, archives, evolving notions of fieldwork). Family sketches cover major language families and isolates and highlight topics of special value to communities engaged in work on language maintenance, documentation, and revitalization.
Автор: Davis Steven, Mithun Marianne Название: Linguistics, Philosophy, and Montague Grammar ISBN: 0292740727 ISBN-13(EAN): 9780292740723 Издательство: Marston Book Services Цена: 36950.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This volume presents significant developments in the field of Montague Grammar and outlines its past and future contributions to philosophy and linguistics.
Автор: Pattankar Mithun, Hurbuns Malendra Название: Mastering ASP.NET Web API ISBN: 1786463954 ISBN-13(EAN): 9781786463951 Издательство: Неизвестно Рейтинг: Цена: 60070.00 T Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Satheesh Mithun, Joseph D`Mello Bruno, Krol Jason Название: Web Development with MongoDB and Node - Third Edition ISBN: 1788395085 ISBN-13(EAN): 9781788395083 Издательство: Неизвестно Рейтинг: Цена: 53940.00 T Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Satheesh Mithun, Joseph D`Mello Bruno, Krol Jason Название: Web Development with MongoDB and NodeJS Second Edition ISBN: 1785287524 ISBN-13(EAN): 9781785287527 Издательство: Неизвестно Рейтинг: Цена: 53940.00 T Наличие на складе: Есть у поставщика Поставка под заказ.
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