Functional Protein Microarrays in Drug Discovery, Predki, Paul F.

Автор: Berrar Daniel P., Dubitzky Werner, Granzow Martin
Название: A Practical Approach to Microarray Data Analysis
ISBN: 1402072600 ISBN-13(EAN): 9781402072604
Издательство: Springer
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Описание: A Practical Approach to Microarray Data Analysis is for all life scientists, statisticians, computer experts, technology developers, managers, and other professionals tasked with developing, deploying, and using microarray technology including the necessary computational infrastructure and analytical tools. The book addresses the requirement of scientists and researchers to gain a basic understanding of microarray analysis methodologies and tools. It is intended for students, teachers, researchers, and research managers who want to understand the state of the art and of the presented methodologies and the areas in which gaps in our knowledge demand further research and development. The book is designed to be used by the practicing professional tasked with the design and analysis of microarray experiments or as a text for a senior undergraduate- or graduate level course in analytical genetics, biology, bioinformatics, computational biology, statistics and data mining, or applied computer science. Key topics covered include: -Format of result from data analysis, analytical modeling/experimentation; -Validation of analytical results; -Data analysis/Modeling task; -Analysis/modeling tools; -Scientific questions, goals, and tasks; -Application; -Data analysis methods; -Criteria for assessing analysis methodologies, models, and tools.

Автор: Catherine J. Wu
Название: Protein Microarray for Disease Analysis
ISBN: 1493961748 ISBN-13(EAN): 9781493961740
Издательство: Springer
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Описание: This comprehensive survey of the field sees expert researchers provide concise descriptions of the most up-to-date methodologies used to fabricate microarrays for the analysis of proteins or responses to proteins that help inform our study of human disease.

Автор: Patrick McConnell; Simon Lin; Patrick Hurban
Название: Methods of Microarray Data Analysis V
ISBN: 1441941797 ISBN-13(EAN): 9781441941794
Издательство: Springer
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Описание: This book is dedicated solely to the analysis of microarray data. Its unique approach of presenting different methods by analyzing the same data set shows the strengths and weakness of each method. Part of the book is devoted to review papers, which provide a more general look at various analytical approaches.

Автор: Uwe R. M?ller; Miguel Nicolau
Название: Microarray Technology and Its Applications
ISBN: 3642061826 ISBN-13(EAN): 9783642061820
Издательство: Springer
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Описание: Ten years ago micro- ray technology emerged as a new and powerful tool to study nucleic acid - quences in a highly multiplexed manner, and has since found equally exciting and useful applications in the study of proteins, metabolites, toxins, viruses, whole cells and even tissues.

Название: Functional Proteomics and Nanotechnology-Based Microarrays
ISBN: 9814267767 ISBN-13(EAN): 9789814267762
Издательство: Taylor&Francis
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Автор: Ulrike Korf
Название: Protein Microarrays
ISBN: 1493957767 ISBN-13(EAN): 9781493957767
Издательство: Springer
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Описание: Protein microarrays can overcome the sensitivity and sample limitations of functional proteomics. This volume is an exhaustive and up-to-date presentation of robust protein microarray strategies that furthers the advance of this powerful laboratory technology.

Автор: Marina Cretich; Marcella Chiari
Название: Peptide Microarrays
ISBN: 1493949683 ISBN-13(EAN): 9781493949687
Издательство: Springer
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Цена: 88500.00 T
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Описание:

Part I: Peptide Arrays: Cutting-Edge Methods and Technology

1. Peptide Arrays on Planar Supports

Vнctor Tapia and Rudolf Volkmer

2. High-Throughput Microarray Incubations Using Multi-Well Chambers

Johannes Zerweck, Ulf Reimer, Janina Jansong, Nikolaus Pawlowski, Christoph Tersch, Maren Eckey, and Tobias Knaute

3. Analysis of Protein Tyrosine Kinase Specificity Using Positional Scanning Peptide Microarrays

Yang Deng and Benjamin E. Turk

4. Secondary Structure Determination of Peptides and Proteins After Immobilization

Stella H. North and Chris R. Taitt

5. Peptides and Anti-Peptide Antibodies for Small and Medium Scale Peptide and Anti-Peptide Affinity Microarrays: Antigenic Peptide Selection, Immobilization, and Processing

Fan Zhang, Andrea Briones, and Mikhail Soloviev

6. Low-Cost Peptide Microarrays for Mapping Continuous Antibody Epitopes

Ryan McBride, Steven R. Head, Phillip Ordoukhanian, and Mansun Law

7. The Peptide Microarray-Based Resonance Light Scattering Assay for Sensitively Detecting Intracellular Kinase Activity

Tao Li, Xia Liu, Dianjun Liu, and Zhenxin Wang

8. Anomalous Reflection of Gold: A Novel Platform for Biochips

Amir Syahir, Kin-ya Tomizaki, Kotaro Kajikawa, and Hisakazu Mihara

9. High Throughput Peptide Screening on a Bimodal Imprinting Chip Through

Автор: Ronald Simon
Название: Tissue Microarrays
ISBN: 1493961039 ISBN-13(EAN): 9781493961030
Издательство: Springer
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Описание: The tissue microarray (TMA) method presents as a modern high technology, although its roots go back to the 80s when researchers frst started to combine several small pieces of tissues into so-called sausage blocks. In this respect, the TMA invention was not frstly characterized by technical improvements, but its true novelty was to link clinical data to the tissues that were combined on one slide. The very high number of tissues that can be included into one TMA, the small size and regular shape of the tissue spots, the preser- tion of integrity of the donor tissue blocks, and the highly organized array pattern that allows for reliable allocation of clinical data to individual tissue spots made it a discrete technique with unique features. When the TMA technology was developed 12 years ago, its beneft was controversially debated. While many researchers welcomed the method enthusiastically, there were c- cerns by others that results obtained from the small tissue cores used for TMA making would not be suffciently representative of the donor tissues. Meanwhile, the increasing use of this technology has imposingly demonstrated its tremendous utility in research. In fact, basically all clinically relevant associations between molecular markers and clinical endpoints could be reproduced using only one single 0. 6 mm core per tissue sample so that TMAs have nowadays become a standard tool allowing for a new dimension of tissue analysis.

Автор: Yann Chevolot
Название: Carbohydrate Microarrays
ISBN: 1493958666 ISBN-13(EAN): 9781493958665
Издательство: Springer
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Цена: 107130.00 T
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Описание: Carbohydrate microarrays emerged as a key technology for the deciphering of the glycospace by providing a multiplex technology where tens to hundreds of carbohydrates/protein interactions can be probed in parallel. Carbohydrate Microarrays: Methods and Protocols aims to give the reader the theoretical and experimental clues necessary for the fabrication and implementation of carbohydrate microarrays. This requires three essential steps: 1) to obtain the carbohydrate probes (monosacharides, oligosacchrides, polysacchairdes, glycoconjugates or glycoclusters), 2) to immobilize these probes, and 3) to implement the protocols for biological/biochemical interaction with the desired target. This volume gives an overview of carbohydrate microarray and carbohydrate chemistry and illustrates different detection techniques and their applications. Written in the successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Carbohydrate Microarrays: Methods and Protocols compiles a catalogue of protocols on carbohydrate microarrays to span the needs of researchers around the globe.

Автор: Mahesh Uttamchandani; Shao Q. Yao
Название: Small Molecule Microarrays
ISBN: 1493958151 ISBN-13(EAN): 9781493958153
Издательство: Springer
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Цена: 158380.00 T
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Описание: Small molecule microarrays (SMM) were introduced just a decade ago in 1999 and, within a short space of time, have already established themselves as a vibrant, next generation platform for high-throughput screening. Small Molecule Microarrays: Methods and Protocols showcases a collection of contributions guiding researchers toward ways in which small molecule microarray technology may be deployed for multiplexed screening and profiling. Organized by the categories of small molecules presented on the microarrays, this detailed volume describes in-depth techniques for chemical libraries, peptide libraries, and carbohydrate microarrays. Written in the highly successful Methods in Molecular Biology™ series, chapters contain brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, vital tips on troubleshooting this often difficult technology, and advice on avoiding known pitfalls. Authoritative and cutting-edge, Small Molecule Microarrays: Methods and Protocols provides meticulous depictions of key hands-on experience and seeks to inspire a future generation of microarray practitioners to take this significant technology forward.

Автор: Mahesh Uttamchandani; Shao Q. Yao
Название: Small Molecule Microarrays
ISBN: 1493965824 ISBN-13(EAN): 9781493965823
Издательство: Springer
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Цена: 130430.00 T
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Описание: Small molecule microarrays (SMM) were introduced in 1999 and within just a short span of time, have established themselves as a vibrant next generation platform for high-throughput screening. Small Molecule Microarrays: Methods and Protocols consolidates a significant collection of examples, which serve to guide researchers toward ways in which SMM technology may be effectively deployed for multiplexed screening, drug discovery and ligand identification. The volume is organized into three sections covering microarray fabrication, imaging modes, and discovery approaches. The chapters cover a range of small molecule library types, ranging from synthetic combinatorial libraries to peptide and carbohydrate libraries, with lessons and techniques that can be widely applied. Written in the highly successful Methods in Molecular Biology series, format, chapters include introductions of their respective topics, lists of the requisite materials and reagents, step-by-step and readily reproducible laboratory protocols as well as vital tips on troubleshooting and advice on avoiding known pitfalls. Authoritative and cutting-edge, Small Molecule Microarrays: Methods and Protocols provides meticulous insights into the successful applications of SMM, by experts in the field. Building on this collection of knowledge, the volume seeks to inspire a future generation of microarray practitioners to propel this significant technology to even greater heights

Автор: Jang B. Rampal
Название: Microarrays
ISBN: 1617376639 ISBN-13(EAN): 9781617376634
Издательство: Springer
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Цена: 153720.00 T
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Описание: These two volumes present information in designing and fabricating arrays and binding studies with biological analytes. This is done while providing the reader with a broad description of microarray technology tools and their potential applications.