Mitochondria in Health and Disease, Berdanier, Carolyn D.
Автор: Lane Nick Название: Power, Sex, Suicide: Mitochondria and the Meaning of Life ISBN: 0198831900 ISBN-13(EAN): 9780198831907 Издательство: Oxford Academ Рейтинг: Цена: 13720.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Mitochondria are tiny structures within all our cells, believed to have once evolved from bacteria living independent lives. Drawing on cutting edge research, this book explores the fundamental role they play in some of the biggest themes in biology: evolution, the origin of the sexes, in growth, ageing, disease, and in death.
Название: Mitochondria in Health and Disease ISBN: 0367392690 ISBN-13(EAN): 9780367392697 Издательство: Taylor&Francis Рейтинг: Цена: 65320.00 T Наличие на складе: Нет в наличии. Описание: It was once assumed that mitochondrial diseases were rare and that few people were affected. As knowledge has grown about these organelles and their function, it became clear that mitochondrial malfunction could be linked to several chronic diseases. Diabetes has been associated with DNA mutation and can cause mutation itself. This text discusses findings involving the effects of disease on mitochondrial number, mitogenesis, and the base sequence of mitochondrial DNA. Experts discuss their study of mitochondria and what happens when it malfunctions. This book also explores the idea that mutated mitochondrial DNA can result in disease, and vice versa.
Автор: Gjumrakch Aliev Название: Role of Oxidative Stress, Mitochondria Failure, & Cellular Hypoperfusion in the Context of Alzheimer Disease: Past, Present & Future ISBN: 1619428784 ISBN-13(EAN): 9781619428782 Издательство: Nova Science Рейтинг: Цена: 299890.00 T Наличие на складе: Невозможна поставка. Описание: Atherosclerosis and stroke are two leading causes of age-associated disability, dementia, and death. The Centers for Disease Control and Prevention (CDC) and the National Center for Health Statistics recently reported that Alzheimers Disease has surpassed diabetes as a leading cause of death. Alzheimer is now the sixth-leading cause of death in the United States. This book discusses the roles of oxidative stress, mitochondria failure, and cellular hypoperfusion in the context of Alzheimer Disease.
Автор: Jos? Mar?n-Garc?a Название: Mitochondria and Their Role in Cardiovascular Disease ISBN: 1489997660 ISBN-13(EAN): 9781489997661 Издательство: Springer Рейтинг: Цена: 153720.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Over the past two decades, due to dramatic advances in molecular and cell biology, biochemistry, and genetics, our view on mitochondria as a relatively static cellular powerhouse has changed radically. We now know that these organelles play a critical role in the normal and in the damaged heart. Written by Dr. Jos? Mar?n-Garc?a, Director of the Molecular Cardiology and Neuromuscular Institute, Mitochondria and Their Role in Cardiovascular Disease brings readers up- to-date on the many significant advances in the field of mitochondrial cardiovascular medicine. The book begins with a general introduction to mitochondria, followed by laboratory methods to study the structure and function of the organelle, regulation of replication and biogenesis, and the mechanisms and functional consequences of mitophagia and mitochondrial dynamics. Subsequent chapters deal with mitochondrial oxidative stress and the role that the organelle plays in cell signaling and cell death. Discussions will be undertaken on the biochemistry of mitochondrial cell signaling, including the nature of the proteins engaged in these processes, many of them only recently discovered. Later chapters examine the role of mitochondria and mitochondrial abnormalities in cardiovascular diseases, including their diagnosis, therapeutic options currently available, animal models of mitochondrial disease, and new frontiers in mitochondria cardiovascular medicine, including areas of research that are relatively new or developing, such as proteomics, next generation sequencing, and systems biology.
Название: Mitochondria in Liver Disease ISBN: 0367377241 ISBN-13(EAN): 9780367377243 Издательство: Taylor&Francis Рейтинг: Цена: 65320.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
...excellent, well-organized, and timely. --Lester Packer and Enrique Cardenas, University of Southern California, Los Angeles, from the Series Preface
The liver is a vital organ that is responsible for a wide range of functions, most of which are essential for survival. The multitude of functions the liver performs makes it vulnerable to a wide range of diseases. Mitochondrial dysfunction plays an important role in many liver diseases including drug-induced liver injury, alcoholic liver disease, and nonalcoholic fatty liver disease. Mitochondria in Liver Disease gathers the most current research regarding the role of mitochondria in the liver and various diseases to which it is susceptible.
The book is separated into two sections, the first of which highlights the latest developments in mitochondrial research. It includes cutting-edge topics such as the regulation of mitochondrial respiration using hydrogen sulfide and the regulation of mitochondrial fusion-fission via the endoplasmic reticulum. The second section reviews the most current research on the role of mitochondria in a wide range of liver diseases. It also addresses novel topics such as the importance of liver mitochondrial constituents as biomarkers of liver injury in plasma and as regulators of the immune system.
Mitochondria in Liver Disease represents the current state of knowledge and research on mitochondrial roles in liver diseases. Written by a group of global experts, it provides an authoritative and comprehensive overview of the latest advances and methods that mark key starting points for future research.
Автор: J. Marie Hardwick Название: The Functions, Disease–Related Dysfunctions, and Therapeutic Targeting of Neuronal Mitochondria ISBN: 1118709233 ISBN-13(EAN): 9781118709238 Издательство: Wiley Рейтинг: Цена: 178410.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book presents advances in the field of neuronal mitochondria functions, relation to therapeutics, and pharmacology. For scientists and researchers in both industry and academia, this book provides detailed discussion, examples, and approaches, to illustrate the potential of mitochondria as therapeutic targets for neuronal diseases.
Автор: Dhyan Chandra Название: Mitochondria as Targets for Phytochemicals in Cancer Prevention and Therapy ISBN: 1461493250 ISBN-13(EAN): 9781461493259 Издательство: Springer Рейтинг: Цена: 156720.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The second part focuses on the elucidation of key target proteins that could be exploited for cancer prevention, an the role of phytochemicals in cancer prevention, updates on basic research related to phytochemicals action critical for cancer prevention, and updates on translational knowledge on cancer prevention by phytochemicals.
Автор: Mokranjac Dejana, Perocchi Fabiana Название: Mitochondria: Practical Protocols ISBN: 1493983091 ISBN-13(EAN): 9781493983094 Издательство: Springer Рейтинг: Цена: 107130.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
A Guide to Computational Methods for Predicting Mitochondrial Localization.- Isolation of Functional Mitochondria from Cultured Cells and Mouse Tissues.- Isolation of Mitochondria From Saccharomyces Cerevisiae.- Isolation of Contact Sites Between Inner and Outer Mitochondrial Membranes.- Isolation Of Mitochondria-Associated Membranes (MAM) from Mouse Brain Tissue.- Label-Free Quantitative Analysis of Mitochondrial Proteomes using the Multienzyme Digestion-Filter Aided Sample Preparation (MED-FASP) and 'Total Protein Approach'.- Quantitative Analysis of Glycerophospholipids in Mitochondria by Mass Spectrometry.- Detection of Cysteine Redox States in Mitochondrial Proteins in Intact Mammalian Cells.- Chemical Crosslinking in Intact Mitochondria.- Reconstitution of Mitochondrial Membrane Proteins into Nanodiscs by Cell-Free Expression.- Detection of Dual Targeting and Dual Function of Mitochondrial Proteins in Yeast.- Localizing Mrnas Encoding Mitochondrial Proteins in Yeast by Fluorescence Microscopy and Subcellular Fractionation.- Assessing Mitochondrial Bioenergetics in Isolated Mitochondria from Various Mouse Tissues using Seahorse XF96 Analyzer.- Application of FRET-Based Biosensor "Ateam" for Visualization of ATP Levels in the Mitochondrial Matrix of Living Mammalian Cells.- A Microplate-Based Bioluminescence Assay of Mitochondrial Calcium Uptake.- New Imaging Tools to Analyze Mitochondrial Morphology in Caenorhabditis Elegans.- Single Molecule Tracking and Localization Of Mitochondrial Protein Complexes in Live Cells.- Analysis of Yeast Mitochondria by Electron Microscopy.- Analysis of Mitochondrial Membrane Protein Complexes by Electron Cryo-Tomography.- Assays for Mitophagy in Yeast.- Assessing Mitochondrial Selective Autophagy in the Nematode Caenorhabditis Elegans.- Assessing Mitochondrial Unfolded Protein Response in Mammalian Cells.- Analysis of Mitochondrial RNA-Processing Defects in Patient-Derived Tissues by Qrt-PCR and Rnaseq.- Identification of Disease-Causing Mutations by Functional Complementation of Patient-Derived Fibroblast Cell Lines.
Автор: Alexander Tzagoloff Название: Mitochondria ISBN: 1461574390 ISBN-13(EAN): 9781461574392 Издательство: Springer Рейтинг: Цена: 93160.00 T Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Justin C. St. John Название: Mitochondrial DNA, Mitochondria, Disease and Stem Cells ISBN: 1627038671 ISBN-13(EAN): 9781627038676 Издательство: Springer Рейтинг: Цена: 148010.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The reader is then introduced to how mtDNA is transmitted through the oocyte and how stem cells can be used to study mitochondrial biogenesis and mtDNA replication and transcription in undifferentiated pluripotent and differentiating cells and how mitochondria adapt during this process.
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