Автор: King, Stephen M. Название: Cilia: Motors And Regulation,92 ISBN: 0123749743 ISBN-13(EAN): 9780123749741 Издательство: Elsevier Science Рейтинг: Цена: 123520.00 T Наличие на складе: Нет в наличии. Описание: A comprehensive source of methods for the analysis cilia and flagella. It covers protocols for cilia and flagella across systems and species. It is suitable for clinicians interested in respiratory disease, male infertility and other syndromes, who need to learn biochemical and genetic approaches to studying cilia, flagella and related structures.
Автор: Marshall Wallace, Basto Renata Название: Cilia ISBN: 1621821412 ISBN-13(EAN): 9781621821410 Издательство: Неизвестно Рейтинг: Цена: 49140.00 T Наличие на складе: Невозможна поставка. Описание: Nearly every cell in the human body has one or more protrusive structures called cilia or flagella. These power cell movement and fluid flow, sense the extracellular environment, coordinate cell signaling, and establish left-right asymmetry during development. Mutations in genes that encode cilia can lead to disorders known as ciliopathies. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology examines key aspects of ciliary biology-from the molecular to the organismal level-in normal physiology and disease. The contributors dissect the complex structures of motile and nonmotile (primary) cilia, discuss how the intraflagellar transport machinery moves cargo across the central axoneme, and review how the ciliary gate controls the composition of cilia and flagella. The roles of cilia in coordinating cellular responses to environmental stimuli via cell signaling pathways (e.g., Hedgehog) are also covered, as are physiological functions in processes such as fertilization, mucociliary clearance, and vision. The authors also survey the wide spectrum of ciliopathies, describing their genetic bases, pathogenic mechanisms, and clinical manifestations. This volume is therefore an indispensable reference for all cell and developmental biologists, as well as medical geneticists and clinical scientists wishing to understand and treat disorders involving ciliary dysfunction.
Автор: Rustem E. Uzbekov Название: Flagella and Cilia: Types, Structure and Functions ISBN: 1536143332 ISBN-13(EAN): 9781536143331 Издательство: Nova Science Рейтинг: Цена: 122490.00 T Наличие на складе: Невозможна поставка. Описание: Motility is an inherent property of living organisms, both unicellular and multicellular. One of the principal mechanisms of cell motility is the use of peculiar biological engines flagella and cilia. These types of movers already appear in prokaryotic cells. However, despite the similar function, bacteria flagellum and eukaryote flagella have fundamentally different structures. Chapter One of this book by Drs. Meijiao Wang, Li Zhang and Hanna Li is devoted to a comparative analysis of the flagella of prokaryotes and eukaryotes.Its believed that flagellum in eukaryotic cells appeared for the first time in ancient flagellates. In Chapter Two, Drs. P. Huitorel, M. Cachon and J. Cosson summarize the results of their long-term studies of flagellum dinoflagellates. The "evolutionary invention" of the ancient flagellates proved to be so successful that the axonemal structure in flagellum has not changed for hundreds of millions of years. In the third chapter, Drs. V. Bondarenko, G. Prokopchuk and J. Cosson reported the analyses of kinetic characteristics of flagella motions in fish using the most modern methodologies.In Chapter Four, Drs. R. Uzbekov, A. Garanina, J. Burlaud-Gaillard and C. Bressac described spermiogenesis of the parasitic wasps Cotesia congregata. Their data showed that significant shortening of the flagella occurs during the formation of the mature spermatozoon and this flagella has been the shortest spermatozoon flagella described in the animal kingdom until now. Centriole in this spermatozoon is transformed into a special structure known as the "cogwheel structure" that does not contain microtubules.In the process of multicellular organism evolution, flagella, which ensure the mobility of individual cells, gave origin to two types of cilia. Motile cilia in the tissues like cerebral ventricles, respiratory epithelium and oviducts moved liquid flows relatively to immobile cell layers. The second type of cilia (primary cilia) lost motility function and acquired cellular sensitivity function. Moving and sensitive cilia grow from basal bodies, which originate from centrioles. Chapter Five by Drs. I. Alieva, C. Staub, S. Uzbekova and R. Uzbekov discusses which of the centrioles mother or daughter creates the moving cilium and sensitive cilium.In Chapter Six, Drs. D. Conkar and E. Nur Firat-Karalar describe in detail the biochemical aspects of primary cilium assembly pathways, intraflagellar transport and ectosome release. This chapter provides an overview of the trafficking pathways involved in ciliary compartmentalization and describes the primary ciliary as a sensitive "cells antenna", participating in many regulatory processes in the cell.Defects in flagella and cilia cause many hereditary diseases. Different examples of ciliopathy are described in Chapter Seven by Drs. E. Bragina, E. Blanchard and R. Uzbekov.A wide review of experimental models, organisms and analytical methods to study flagella and cilia are presented to readers who want to learn about their main research directives.
Автор: Satir Название: Cilia ISBN: 1493937871 ISBN-13(EAN): 9781493937875 Издательство: Springer Рейтинг: Цена: 88500.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This volume is the result of an explosion ofmolecular-based research on Cilia, which began with the discovery of theuniversality of intraflagellar transport (IFT) and ciliary genomics/proteomics.The chapters in this book cover topics such as: high resolution imaging andfunctional characterization of sensory and primary cilia in mammalian cells andzebrafish, methods to study ciliary-mediated chemoresponse in Paramecium,and methods to study centrosomes and cilia in C. elegans and Drosophila.Written in the highly successful Methods in Molecular Biology series format,chapters include introduction to their respective topics, lists of thenecessary materials and reagents, step-by-step, readily reproducible laboratoryprotocols, and tips on troubleshooting and avoiding known pitfalls.Practical and cutting-edge, Cilia:Methods and Protocols is broad and covers motile, sensory, and primarycells. It is a valuable resource to anyone interested in entering the field ofciliary biology using model organisms, including flagellate algae, ciliates,planaria, nematodes, insects, zebrafish, and mammalian cells.
Автор: King, Stephen M. Название: Cilia: Structure And Motility,91 ISBN: 0123749735 ISBN-13(EAN): 9780123749734 Издательство: Elsevier Science Рейтинг: Цена: 140360.00 T Наличие на складе: Нет в наличии. Описание: A comprehensive source of methods for the analysis cilia and flagella. It covers protocols for cilia and flagella across systems and species. It is suitable for clinicians interested in respiratory disease, male infertility and other syndromes, who need to learn biochemical and genetic approaches to studying cilia, flagella and related structures.
Автор: Satir Peter, Christensen Sшren Tvorup Название: Cilia: Methods and Protocols ISBN: 1493981390 ISBN-13(EAN): 9781493981397 Издательство: Springer Рейтинг: Цена: 46570.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
1. Methods for Studying Ciliary Import Mechanisms Daisuke Takao and Kristen J. Verhey
2.Targeting of ASH Domain-Containing Proteins to the Centrosome Patricia Verdier, Stine K. Morthorst, and Lotte B. Pedersen 3.Morphological and Functional Characterization of the Ciliary Pocket by Electron and Fluorescence Microscopy Rania Ghossoub, Louise Lindb k, Anahi Molla-Herman, Alain Schmitt, S ren Tvorup Christensen, and Alexandre Benmerah 4.Methods to Study Interactions between Ciliogenesis and Autophagy Birgit H. Satir and Olatz Pampliega 5.Recombinant Reconstitution and Purification of the IFT B Core Complex from Chlamydomonas reinhardtii Michael Taschner and Esben Lorentzen 6.Methods for Studying Movement of Molecules within Cilia Karl F. Lechtreck 7.A FRAP-Based Method for Monitoring Molecular Transport in Ciliary Photoreceptor Cells In Vivo Kirsten A. Wunderlich and Uwe Wolfrum 8. Kymographic Analysis of Transport in an Individual Neuronal Sensory Cilium in Caenorhabditis elegans Robert O'Hagan and Maureen M. Barr 9.Visualization and Manipulation of Cilia and Intraciliary Calcium in the Zebrafish Left-Right Organizer Shiaulou Yuan and Martina Brueckner 10.Methods for Studying Ciliary-Mediated Chemoresponse in Paramecium M.S. Valentine and J.L. Van Houten 11.STED and STORM Superresolution Imaging of Primary Cilia T. Tony Yang, Weng Man Chong, and Jung-Chi Liao 12.CLEM Methods for Studying Primary Cilia Frank P. Macaluso, Geoffrey S. Perumal, Johan Kolstrup, and Peter Satir 13.Methods for Visualization of Neuronal Cilia Tamara Caspary, Daniela Marazziti, and Nicolas F. Berbari 14.Methods to Study Centrosomes and Cilia in Drosophila Swadhin Chandra Jana, Susana Mendonзa, Sascha Werner, and Monica Betterncourt-Dias 15.Analysis of Axonemal Assembly during Ciliary Regeneration in Chlamydomonas Emily L. Hunter, Winfield S. Sale, and Lea M. Alford 16.Planaria as a Model System for the Analysis of Ciliary Assembly and Motility Stephen M. King and Ramila S. Patel-King
Автор: Kerry L. Tucker; Tamara Caspary Название: Cilia and Nervous System Development and Function ISBN: 9401782954 ISBN-13(EAN): 9789401782951 Издательство: Springer Рейтинг: Цена: 156720.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This text embraces the welter of recent research on the crucial role played by cilia in the development and activity of the central nervous system. It features cutting-edge analysis by lead researchers into cilia`s functions in the brain and spinal cord.
Автор: Michael Melkonian; Robert A. Andersen; Eberhard Sc Название: The Cytoskeleton of Flagellate and Ciliate Protists ISBN: 3709173914 ISBN-13(EAN): 9783709173916 Издательство: Springer Рейтинг: Цена: 130610.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Protists are fascinating organisms that have diversified and protozoologists. For example, phycologists use the evolutionarily to inhabit most of the biosphere. Their term "basal body" while protozoologists use "kine- tosome"; mycologists were indifferent and used both cytoskeleton is the primary reason that such a diver- sification is possible. Microtubules provided freedom terms from the constraint of prokaryotic cell walls and they As knowledge increased, it became more and more were organized in various cytoskeletal configurations. apparent that the organisms studied in the classical The nine pairs plus two flagellum, a major component fields did not fit into monophyletic lineages. And when of many protistan cytoskeletons, gave a new meaning efforts were made to organize the protists into a phy- to the word motility beginning at least one thousand logenetic classification, it became strikingly apparent million years ago. Associated with the development of that we needed a common vocabulary. Until such a the flagellum were new contractile and noncontractile common vocabulary exists, it will remain difficult to proteins that are necessary for control and manipu- compare studies by scientists from different fields, it lation of the flagella. As the new protists ventured out will be difficult to identify homologous structures into new habitats and filled new niches, they evolved among protists, and the historical barriers created by new ways of sensing their surrounding environment. individual fields of mycology, phycology and proto- Phototactic responses became tightly coupled with the zoology will remain.
Автор: Andrzej Ehrenfeucht; Tero Harju; Ion Petre; David Название: Computation in Living Cells ISBN: 3642074014 ISBN-13(EAN): 9783642074011 Издательство: Springer Рейтинг: Цена: 65290.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
Natural Computing is concerned with computation that is taking place in Nature. The investigation of computations in living cells is one of the central and fastest growing areas of research in this field. Gene assembly in ciliates (unicellular organisms) is a splendid example of such computations, and it is fascinating from both the biological and the computational viewpoints. As a matter of fact, both biology and the science of computation have benefited from the interdisciplinary research on the computational nature of gene assembly - this work has helped to clarify important biological aspects of gene assembly, yielded novel insights into the nature of computation, and broadened our understanding of what computation is about.
This monograph gives an accessible account of both the biology and the formal analysis of the gene assembly process. It can be used as a textbook for either graduate courses or seminars.
Автор: Yoder, Bradley Название: Ciliary Function In Mammalian Development,85 ISBN: 0123744539 ISBN-13(EAN): 9780123744531 Издательство: Elsevier Science Рейтинг: Цена: 162820.00 T Наличие на складе: Нет в наличии. Описание: Cilia - the tiny hair-like structures on the surface of cells - have been identified as playing a role in a variety of disease and developmental disorders. This volume presents the fresh findings in cilia research and thought on the role of cilia in disease and developmental abnormalities.
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