Автор: Jiro Nagatomi , Eno Essien Ebong (Editors) Название: Mechanobiology Handbook, 2Nd Ed ISBN: 1498779468 ISBN-13(EAN): 9781498779463 Издательство: Taylor&Francis Цена: 168430 T Наличие на складе: Нет в наличии. Описание: This is a substantial revision of a former reference work, now developed as a primary text for emerging courses in mechanobiology/cell mechanics being offered in a growing number of biomedical engineering and chemical engineering departments worldwide. It will also serve as a professional reference book for engineers, scientists and clinicians.
Автор: Jiro Nagatomi , Eno Essien Ebong (Editors) Название: Mechanobiology Handbook, 2Nd Ed ISBN: 1498779468 ISBN-13(EAN): 9781498779463 Издательство: Taylor&Francis Рейтинг: Цена: 168430.00 T Наличие на складе: Нет в наличии. Описание: This is a substantial revision of a former reference work, now developed as a primary text for emerging courses in mechanobiology/cell mechanics being offered in a growing number of biomedical engineering and chemical engineering departments worldwide. It will also serve as a professional reference book for engineers, scientists and clinicians.
Автор: Chien Название: Molecular and Cellular Mechanobiology ISBN: 1493956159 ISBN-13(EAN): 9781493956159 Издательство: Springer Рейтинг: Цена: 144410.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book will cover the cutting-edge developments in molecular and cellular mechanobiology to date. Readers will have a clear understanding of mechanobiology at the molecular and cellular levels, encompassing the mechanosensors, transducers, and transcription. An integrative approach across different scales from molecular sensing to mechanotransduction and gene modulation for physiological regulation of cellular functions will be explored, as well as applications to pathophysiological states in disease. A comprehensive understanding of the roles of physicochemical microenvironment and intracellular responses in determining cellular function in health and disease will also be discussed.
Название: Mechanobiology Handbook ISBN: 1138072265 ISBN-13(EAN): 9781138072268 Издательство: Taylor&Francis Рейтинг: Цена: 107190.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
Mechanobiology--the study of the effects of mechanical environments on the biological processes of cells--has evolved from traditional biomechanics via the incorporation of strong elements of molecular and cell biology. Currently, a broad range of organ systems are being studied by surgeons, physicians, basic scientists, and engineers. These mechanobiologists aim to create new therapies and further biological understanding by quantifying the mechanical environment of cells and the molecular mechanisms of mechanically induced pathological conditions.
To achieve these goals, investigators must be familiar with both the basic concepts of mechanics and the modern tools of cellular/molecular biology. Unfortunately, current literature contains numerous studies that misuse standard mechanical estimations and terminology, or fail to implement appropriate molecular analyses. Therefore, the Mechanobiology Handbook not only presents cutting-edge research findings across various fields and organ systems, but also provides the elementary chapters on mechanics and molecular analysis techniques to encourage cross-field understanding and appropriate planning.
Aided by the continuous advancement of research tools in both mechanics and biology, more sophisticated experiments and analyses are possible--thus fueling the growth of the field of mechanobiology. Considering the complexity of the mechanics and the biology of the human body, most of the world of biomechanics remains to be studied. Since the field is still developing, the Mechanobiology Handbook does not force one unified theory, but brings out many different viewpoints and approaches to stimulate further research questions.
The Mechanophysiololgy of Stress Fractures in Military Recruits.- Traumatic Brain Injury in the Military: Biomechanics and Finite Element Modelling.- Modeling Skeletal Injuries in Military Scenarios.- Biomechanics of Eye Injury in the Military.- The Biomechanical Basis for Increased Risk of Overuse Musculoskeletal Injuries in Female Soldiers.
Автор: Andr?s D?az Lantada Название: Microsystems for Enhanced Control of Cell Behavior ISBN: 3319293265 ISBN-13(EAN): 9783319293264 Издательство: Springer Рейтинг: Цена: 156720.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Part I Fundamentals.- Introduction to microsystems in the biomedical field.- Some introductory notes on cell biology.- Some introductory notes on cell mechanics and mechanobiology.- Some introductory notes on engineering resources for interacting with cells.- II. Design and Manufacturing Strategies.- Overview of design and manufacturing strategies for biomedical microsystems.- Biomimetic computer-aided design: Addressing the complexity of biomaterials.- Multi-scale and multi-physics/chemistry modeling in biomedical microsystems.- Rapid prototyping of biomedical microsystems for interacting at a cellular level.- Nanomanufacturing for biomedical microsystems interacting at a molecular scale.- Characterization technologies for biomedical microsystems interacting with cells.- Issues linked to the mass-production of biomedical microsystems.- Part III Applications.- Overview of applications based on microsystems capable of interacting with cells.- Microfluidic devices for in vitro drug screening and detection.- Microfluidic devices for enhanced disease diagnosis and modeling.- Cell-based sensors and related microsystems.- Cell-based actuators and related microsystems.- Microsystems for the study of cells subject to gradients of chemicals.- Electrophoretic microsystems for studying cell mechanics.- Microtextured and microstructured biodevices for studying cell adhesion and dynamics.- Microtextured and.- microstructured cell culture matrixes for controlling cell behavior.- Resonant microsystems for controlling cell growth and differentiation.- Microtextured and microstructured prostheses for enhanced biocompatibility.- Microsystems for the study of cell interactions within physiological structures.- Biomimetic microsystems inspired in complete organs and their structures.- Part IV Present Challenges and Future Proposals.- Towards reliable organs-on-chips and humans-on-chips.- Towards reliable biomanufacturing technologies.- Towards a systematic methodology for the development of biomedical microdevices.- Project-based learning in the field of biomedical microdevices.
Автор: Liesbet Geris; David Gomez-Cabrero Название: Uncertainty in Biology ISBN: 3319212958 ISBN-13(EAN): 9783319212951 Издательство: Springer Рейтинг: Цена: 130430.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Computational modeling allows to reduce, refine and replace animal experimentation as well as to translate findings obtained in these experiments to the human background. However these biomedical problems are inherently complex with a myriad of influencing factors, which strongly complicates the model building and validation process. This book wants to address four main issues related to the building and validation of computational models of biomedical processes: 1. Modeling establishment under uncertainty 2. Model selection and parameter fitting 3. Sensitivity analysis and model adaptation 4. Model predictions under uncertainty In each of the abovementioned areas, the book discusses a number of key-techniques by means of a general theoretical description followed by one or more practical examples. This book is intended for graduate students and researchers active in the field of computational modeling of biomedical processes who seek to acquaint themselves with the different ways in which to study the parameter space of their model as well as its overall behavior.
Автор: Suvranu De; Wonmuk Hwang; Ellen Kuhl Название: Multiscale Modeling in Biomechanics and Mechanobiology ISBN: 1447165985 ISBN-13(EAN): 9781447165989 Издательство: Springer Рейтинг: Цена: 130430.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Presenting a state-of-the-art overview of theoretical and computational models that link characteristic biomechanical phenomena, this book provides guidelines and examples for creating multiscale models in representative systems and organisms. It develops the reader's understanding of and intuition for multiscale phenomena in biomechanics and mechanobiology, and introduces a mathematical framework and computational techniques paramount to creating predictive multiscale models. Biomechanics involves the study of the interactions of physical forces with biological systems at all scales – including molecular, cellular, tissue and organ scales. The emerging field of mechanobiology focuses on the way that cells produce and respond to mechanical forces – bridging the science of mechanics with the disciplines of genetics and molecular biology. Linking disparate spatial and temporal scales using computational techniques is emerging as a key concept in investigating some of the complex problems underlying these disciplines. Providing an invaluable field manual for graduate students and researchers of theoretical and computational modelling in biology, this book is also intended for readers interested in biomedical engineering, applied mechanics and mathematical biology.
Автор: A. Holzapfel Название: Biomechanics: Trends in Modeling and Simulation ISBN: 3319414739 ISBN-13(EAN): 9783319414737 Издательство: Springer Рейтинг: Цена: 139750.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The book presents a state-of-the-art overview of biomechanical and mechanobiological modeling and simulation of soft biological tissues. Seven well-known scientists working in that particular field discuss topics such as biomolecules, networks and cells as well as failure, multi-scale, agent-based, bio-chemo-mechanical and finite element models appropriate for computational analysis. Applications include arteries, the heart, vascular stents and valve implants as well as adipose, brain, collagenous and engineered tissues.The mechanics of the whole cell and sub-cellular components as well as the extracellular matrix structure and mechanotransduction are described. In particular, the formation and remodeling of stress fibers, cytoskeletal contractility, cell adhesion and the mechanical regulation of fibroblast migration in healing myocardial infarcts are discussed. The essential ingredients of continuum mechanics are provided. Constitutive models of fiber-reinforced materials with an emphasis on arterial walls and the myocardium are discussed and the important influence of residual stresses on material response emphasized. The mechanics and function of the heart, the brain and adipose tissues are discussed as well. Particular attention is focused on microstructural and multi-scale modeling, finite element implementation and simulation of cells and tissues.
Автор: Joaquim Miguel Oliveira Rui Luis Reis Название: Regenerative Strategies for the Treatment of Knee Joint Disabilities ISBN: 3319447831 ISBN-13(EAN): 9783319447834 Издательство: Springer Рейтинг: Цена: 139750.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book presents regenerative strategies for the treatment of knee joint disabilities. The book is composed of four main sections totaling 19 chapters which review the current knowledge on the clinical management and preclinical regenerative strategies. It examines the role of different natural-based biomaterials as scaffolds and implants for addressing different tissue lesions in the knee joint. Section one provides an updated and comprehensive discussion on articular cartilage tissue regeneration. Section two focuses on the important contributions for bone and osteochondral tissue engineering. Section three overview the recent advances on meniscus repair/regeneration strategies. Finally, section four further discusses the current strategies for treatment of ligament lesions. Each chapter is prepared by world know expert on their fields, so we do firmly believe that the proposed book will be a reference in the area of biomaterials for regenerative medicine.
Автор: Yohan Payan Название: Soft Tissue Biomechanical Modeling for Computer Assisted Surgery ISBN: 3642438792 ISBN-13(EAN): 9783642438790 Издательство: Springer Рейтинг: Цена: 130590.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This volume focuses on the biomechanical modeling of deformable soft tissues in the context of Computer Assisted Surgery (CAS). Discussion includes biomechanical models, estimation of in vivo mechanical behavior, real-time numerical simulations and more.
Автор: Lynne E. Bilston Название: Neural Tissue Biomechanics ISBN: 3642270050 ISBN-13(EAN): 9783642270055 Издательство: Springer Рейтинг: Цена: 130590.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Neural Tissue Biomechanics reviews the methods used to characterize nonlinear viscoelastic properties of central and peripheral neural tissues. Readers will find a comprehensive picture of the mechanical and biological response of neural tissues, including the full spectrum of mechanical loading.
Автор: Amit Gefen Название: Cellular and Biomolecular Mechanics and Mechanobiology ISBN: 3642267262 ISBN-13(EAN): 9783642267260 Издательство: Springer Цена: 139310.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
Preface.- Fundamental concepts .- Cytoskeletal mechanics and cellular mechanotransduction: A molecular perspective.- Forces during cell adhesion and spreading: implications for cellular homeostasis.- The physical mechanical processes that shape tissues in the early embryo.- Mechanobiology of primary cilia.- Mechanical response of living cells to contacting shear force.- Experimental methods.- Microfabricated devices for studying cellular biomechanics and mechanobiology.- Nanotechnology usages for cellular adhesion and traction forces.- Global and local effects in three-dimensional biological hydrogels.- Global and local effects in three-dimensional biological hydrogels.- Global and local effects in three-dimensional biological hydrogels.- Biomechanical characterization of single chondrocytes.- Mechanics of airway smooth muscle cells and the response to stretch.- Computational modeling.- Biomechanical modelling of cells in mechanoregulation.- Finite element modeling of cellular mechanics experiments.- Multiscale computation of cytoskeletal mechanics during blebbing.- Mechanobiology and finite element analysis of cellular injury during microbubble flows.- Mathematical modeling of cell adhesion in tissue engineering using continuum models.- Cell-material communication: mechanosensing modelling for design in tissue engineering.- Mechanobiology in cancer .- Structure-mechanical property changes in nucleus arising from breast cancer.- Adhesion and signaling of tumor cells to leukocytes and endothelium in cancer metastasis.- Cellular mechanics of acute leukemia and chemotherapy
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