Endogenous and Exogenous Regulation and Control of Physiological Systems, Northrop, Robert B.

Автор: Merab G. Tsagareli
Название: Antinociceptive Tolerance to NSAIDs in Brain Limbic Areas: Role of Endogenous Opioid and Cannabinoid Systems
ISBN: 1536198145 ISBN-13(EAN): 9781536198140
Издательство: Nova Science
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Цена: 89750.00 T
Наличие на складе: Невозможна поставка.
Описание: The development of pain as a common experience and its treatment is very important, not only where it is caused by injury or inflammation, but also in chronic states where the nerves themselves are damaged. Even though we already know from physiological studies that special pain receptors or nociceptors are responsible for conducting pain sensations to the brain, the phenomenon of pain remains a medical and social problem. Pain relief or analgesia can be achieved using several different approaches and strategies. Non-steroidal anti-inflammatory drugs are the most widely used analgesics. They have analgesic, antipyretic, and, at higher doses, anti-inflammatory actions. However, a few recent studies have demonstrated that in the case of their prolonged use, these non-opioid drugs elicit the opioid-like effect of tolerance, which alongside drug withdrawal syndrome may entail serious adverse effects. This book provides up-to-date review information and experimental findings concerning antinociceptive tolerance to NSAIDs. The first three chapters after the introduction are devoted to literature reviews on brain limbic areas, opioid and cannabinoid systems, and non-opioid antinociceptive tolerance. Chapters Five, Six and Seven describe research data on antinociceptive tolerance to NSAIDs and opioid and cannabinoid mechanisms of attenuation of nociceptive hyperalgesia in the cingulate cortex, insular cortex, and central amygdala. Chapters Eight, Nine and Ten include discussion, summary and conclusions, as well as a detailed description of experimental materials and methods.

Автор: Mari Dezawa
Название: Muse Cells
ISBN: 443156845X ISBN-13(EAN): 9784431568452
Издательство: Springer
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Цена: 139750.00 T
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Описание: This book provides the first comprehensive account of multilineage-differentiating stress-enduring (Muse) cells, a pluripotent and non-tumorigenic subpopulation of mesenchymal stem cells (MSCs) that have the ability to detect damage signals, migrate to damaged sites, and spontaneously differentiate into cells compatible with the affected tissue, thereby enabling repair of all tissue types. The coverage encompasses everything from the basic properties of Muse cells to their tissue repair effects and potential clinical applications—for example, in acute myocardial infarction, stroke, skin injuries and ulcers, renal failure, and liver disease. An important technical chapter provides a practical and precise protocol for the isolation of Muse cells, which will enable readers to use Muse cells in their own research. In offering fascinating insights into the strategic organization of the body’s reparative function and explaining how full utilization of Muse cells may significantly enhance the effectiveness of MSC treatment, the book will be of high value for Ph.D. students, postdocs, basic researchers, clinical doctors, and industrial developers.

Автор: Friedrich Koch-Nolte
Название: Endogenous ADP-Ribosylation
ISBN: 3319345974 ISBN-13(EAN): 9783319345970
Издательство: Springer
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Цена: 121890.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:

Part I: Evolution and Detection of Endogenous ADP-Ribosylation

The natural history of ADP-ribosyltransferases and the ADP ribosylation system

L. Aravind, Dapeng Zhang, Robson F. de Souza, Swadha Anand and Lakshminarayan M. Iyer

Identification and Analysis of ADP-ribosylated Proteins

Friedrich Haag and Friedrich Buck

Part II: ADP-Ribosylation by ARTCs (R-S-E ARTs)

Photorhabdus luminescens toxins TccC3 and TccC5: Insecticidal ADP-ribosyltransferases that modify threonine and glutamine

Klaus Aktories, Gudula Schmidt and Alexander E. Lang

Reaction mechanism of mono-ADP-ribosyltransferase based on structures of the complex of enzyme and substrate protein

Hideaki Tsuge, Toshiharu Tsurumura

Regulation of nitrogenase by reversible mono-ADP-ribosylation

Vivian R. Moure, Flavia F. Costa, Leonardo M. Cruz, Fabio O. Pedrosa, Emanuel M. Souza, Xiao-Dan Li, Fritz Winkler and Luciano F. Huergo

ADP-ribosylation of P2X7: a matter of life and death for regulatory T cells and natural killer T cells

Bjцrn Rissiek, Friedrich Haag, Olivier Boyer, Friedrich Koch-Nolte, Sahil Adriouch

Pierisins and CARP-1: ADP-ribosylation of DNA by ARTCs in butterflies and shellfish

Tsuyoshi Nakano, Azusa Takahashi-Nakaguchi, Masafumi Yamamoto, and Masahiko Watanabe

Part III: ADP-Ribosylation by ARTDs (H-Y-E ARTs)

Comparative structural analysis of the putative mono-ADP-ribosyltransferases of the ARTD/PARP family

Ana Filipa Pinto and Herwig Schьler

Function and regulation of the mono-ADP-ribosyltransferase ARTD10

Max Kaufmann, Karla L. H. Feijs, and Bernhard Lьscher

Regulation of nucleocytoplasmic transport by ADP-ribosylation: the emerging role of karyopherin-β1 mono-ADP-ribosylation by ARTD15

Maria Di Girolamo

Автор: Friedrich Koch-Nolte
Название: Endogenous ADP-Ribosylation
ISBN: 3319107704 ISBN-13(EAN): 9783319107707
Издательство: Springer
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Цена: 130430.00 T
Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:

Part I: Evolution and Detection of Endogenous ADP-Ribosylation

The natural history of ADP-ribosyltransferases and the ADP ribosylation system

L. Aravind, Dapeng Zhang, Robson F. de Souza, Swadha Anand and Lakshminarayan M. Iyer

Identification and Analysis of ADP-ribosylated Proteins

Friedrich Haag and Friedrich Buck

Part II: ADP-Ribosylation by ARTCs (R-S-E ARTs)

Photorhabdus luminescens toxins TccC3 and TccC5: Insecticidal ADP-ribosyltransferases that modify threonine and glutamine

Klaus Aktories, Gudula Schmidt and Alexander E. Lang

Reaction mechanism of mono-ADP-ribosyltransferase based on structures of the complex of enzyme and substrate protein

Hideaki Tsuge, Toshiharu Tsurumura

Regulation of nitrogenase by reversible mono-ADP-ribosylation

Vivian R. Moure, Flavia F. Costa, Leonardo M. Cruz, Fabio O. Pedrosa, Emanuel M. Souza, Xiao-Dan Li, Fritz Winkler and Luciano F. Huergo

ADP-ribosylation of P2X7: a matter of life and death for regulatory T cells and natural killer T cells

Bjцrn Rissiek, Friedrich Haag, Olivier Boyer, Friedrich Koch-Nolte, Sahil Adriouch

Pierisins and CARP-1: ADP-ribosylation of DNA by ARTCs in butterflies and shellfish

Tsuyoshi Nakano, Azusa Takahashi-Nakaguchi, Masafumi Yamamoto, and Masahiko Watanabe

Part III: ADP-Ribosylation by ARTDs (H-Y-E ARTs)

Comparative structural analysis of the putative mono-ADP-ribosyltransferases of the ARTD/PARP family

Ana Filipa Pinto and Herwig Schьler

Function and regulation of the mono-ADP-ribosyltransferase ARTD10

Max Kaufmann, Karla L. H. Feijs, and Bernhard Lьscher

Regulation of nucleocytoplasmic transport by ADP-ribosylation: the emerging role of karyopherin-β1 mono-ADP-ribosylation by ARTD15

Maria Di Girolamo