Applications of Genome Modulation and Editing, Green, George Dawes
Автор: The Royal Society, National Academy of Sciences, National Academy of Medicine Название: Heritable Human Genome Editing ISBN: 0309671132 ISBN-13(EAN): 9780309671132 Издательство: Неизвестно Рейтинг: Цена: 89660.00 T Наличие на складе: Невозможна поставка. Описание:
Heritable human genome editing - making changes to the genetic material of eggs, sperm, or any cells that lead to their development, including the cells of early embryos, and establishing a pregnancy - raises not only scientific and medical considerations but also a host of ethical, moral, and societal issues. Human embryos whose genomes have been edited should not be used to create a pregnancy until it is established that precise genomic changes can be made reliably and without introducing undesired changes - criteria that have not yet been met, says Heritable Human Genome Editing.
From an international commission of the U.S. National Academy of Medicine, U.S. National Academy of Sciences, and the U.K.'s Royal Society, the report considers potential benefits, harms, and uncertainties associated with genome editing technologies and defines a translational pathway from rigorous preclinical research to initial clinical uses, should a country decide to permit such uses. The report specifies stringent preclinical and clinical requirements for establishing safety and efficacy, and for undertaking long-term monitoring of outcomes. Extensive national and international dialogue is needed before any country decides whether to permit clinical use of this technology, according to the report, which identifies essential elements of national and international scientific governance and oversight.
Автор: Kozubek, James (massachusetts Institute Of Technology) Название: Modern prometheus ISBN: 1108454623 ISBN-13(EAN): 9781108454629 Издательство: Cambridge Academ Рейтинг: Цена: 21110.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This updated paperback edition contains all the very latest on the dramatic story of Crispr and the potential impact of this gene-editing technology.
Автор: Bandyopadhyay Название: Rice Genome Engineering and Gene Editing ISBN: 1071610708 ISBN-13(EAN): 9781071610701 Издательство: Springer Рейтинг: Цена: 121110.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This detailed volume explores rice molecular biology, genetic engineering, and genome editing technologies. Dividing into three parts, the book covers subjects such as genetic engineering and tissue culture of rice, including efficient methods for rice transformation and regeneration, genome editing, targeted integration, and gene stacking in rice, including multiple methods utilizing CRISPR systems for targeted gene knock-out or genome modification via base editing, and diverse methods describing bioinformatic, molecular, and cellular analyses in rice. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Rice Genome Engineering and Gene Editing: Methods and Protocols serves as a valuable resource for researchers worldwide striving to further their efforts on advancing research and producing genetically improved rice varieties.
Автор: Takashi Yamamoto Название: Targeted Genome Editing Using Site-Specific Nucleases ISBN: 4431562354 ISBN-13(EAN): 9784431562351 Издательство: Springer Рейтинг: Цена: 149060.00 T Наличие на складе: Поставка под заказ. Описание: This book serves as an introduction to targeted genome editing, beginning with the background of this rapidly developing field and methods for generation of engineered nucleases. Applications of genome editing tools are then described in detail, in iPS cells and diverse organisms such as mice, rats, marine invertebrates, fish, frogs, and plants. Tools that are mentioned include zinc finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and CRISPR/Cas9, all of which have received much attention in recent years as breakthrough technologies. Genome editing with engineered nucleases allows us to precisely change the target genome of living cells and is a powerful way to control functional genes. It is feasible in almost all organisms ranging from bacteria to plants and animals, as well as in cultured cells such as ES and iPS cells. Various genome modifications have proven successful, including gene knockout and knock-in experiments with targeting vectors and chromosomal editing. Genome editing technologies hold great promise for the future, for example in biomedical research, clinical medicine, and generation of crops and livestock with desirable traits. A wide range of readers will find this book interesting, and with its focus on applications in a variety of organisms and cells, the book will be valuable for life scientists in all fields.
Автор: Mudziwapasi, Reagan (lupane State University, Zimbabwe) Chekera, Ringisai (lupane State University, Zimbabwe) Ncube, Clophas Zibusiso Shoko, Irvonnie Название: Genome editing tools and gene drives ISBN: 0367745968 ISBN-13(EAN): 9780367745967 Издательство: Taylor&Francis Рейтинг: Цена: 40820.00 T Наличие на складе: Невозможна поставка. Описание: This book succinctly reviews and describes genome editing tools such as ZFNs, CRISPR, megaTALs and TALENs. It covers the history, principles, applications and the advantages and disadvantages of each tool. The book provides an approachable outline enhancing science education in schools and universities by demystifying genome editing technologies.
Автор: Turksen Название: Genome Editing ISBN: 3319341464 ISBN-13(EAN): 9783319341460 Издательство: Springer Рейтинг: Цена: 130430.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание:
This timely volume explores the use of CRISPR-Cas9 for genome editing, presenting cutting-edge techniques and their applications in treatment of disease. The chapters describe latest methods such as use of targetable nucleases, investigation of the non-coding genome, mouse genome editing, increasing of knock-in efficiency in mouse zygotes, and generation of reporter stem cells; the text contextualizes these methods in treatment of cardiovascular disease, diabetes mellitus, retinitis pigmentosa, and others. The final chapters round out the book with a discussion of controversies and future directions.
Genome Editing is an essential, of-the-moment contribution to this rapidly growing field. Drawing from a wealth of international perspectives, it presents novel techniques and applications for the engineering of the human genome. This book is essential reading for all clinicians and researchers in stem cells, regenerative medicine, genomics, biochemical and biomedical engineering- especially those interested in learning more about genome editing and applying it in a targeted, specific way.
Автор: Hamner Everett Название: Editing the Soul: Science and Fiction in the Genome Age ISBN: 0271079320 ISBN-13(EAN): 9780271079325 Издательство: NBN International Рейтинг: Цена: 126710.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: An interdisciplinary exploration of how genetic engineering is transforming our narratives about the core of human personhood, and how those narratives are shaping official policies.
Автор: Yamamoto, Takashi Название: Targeted Genome Editing Using Site-Specific Nucleases ISBN: 443155226X ISBN-13(EAN): 9784431552260 Издательство: Springer Рейтинг: Цена: 149060.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book serves as an introduction to targeted genome editing, beginning with the background of this rapidly developing field and methods for generation of engineered nucleases. Applications of genome editing tools are then described in detail, in iPS cells and diverse organisms such as mice, rats, marine invertebrates, fish, frogs, and plants. Tools that are mentioned include zinc finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and CRISPR/Cas9, all of which have received much attention in recent years as breakthrough technologies. Genome editing with engineered nucleases allows us to precisely change the target genome of living cells and is a powerful way to control functional genes. It is feasible in almost all organisms ranging from bacteria to plants and animals, as well as in cultured cells such as ES and iPS cells. Various genome modifications have proven successful, including gene knockout and knock-in experiments with targeting vectors and chromosomal editing. Genome editing technologies hold great promise for the future, for example in biomedical research, clinical medicine, and generation of crops and livestock with desirable traits. A wide range of readers will find this book interesting, and with its focus on applications in a variety of organisms and cells, the book will be valuable for life scientists in all fields.
Название: Genome editing and engineering : ISBN: 1107170370 ISBN-13(EAN): 9781107170377 Издательство: Cambridge Academ Рейтинг: Цена: 166850.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Endonuclease-based genomic engineering is a field with broad potential applications for the treatment of human disease. This complete reference covers the discovery, basic science and application, making it invaluable for researchers and graduate students across the biomedical sciences, and those in the biotechnology and pharmaceutical industries.
Автор: Bandyopadhyay Anindya, Thilmony Roger Название: Rice Genome Engineering and Gene Editing: Methods and Protocols ISBN: 1071610678 ISBN-13(EAN): 9781071610671 Издательство: Springer Цена: 121110.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This volume in the Encyclopedia of Sustainability Science and Technology, Second Edition, describes the breadth of science and engineering knowledge critical to advancing sustainable built environments, from architecture and design, mechanical engineering, lighting, and materials to water and energy, public policy, and economics.
Название: Genome editing in plants ISBN: 0367415909 ISBN-13(EAN): 9780367415907 Издательство: Taylor&Francis Рейтинг: Цена: 117390.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: The initial chapters describe different genome editing tools, their principles and applications. Other chapters are dedicated to present status and future applications of genome editing techniques in various crop improvement programs.
Автор: Prakash Название: Principles and Practices of OMICS and Genome Editing for Crop Improvement ISBN: 303096924X ISBN-13(EAN): 9783030969240 Издательство: Springer Рейтинг: Цена: 158380.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Global food security is increasingly challenging in light of population increase, the impact of climate change on crop production, and limited land available for agricultural expansion. Plant breeding and other agricultural technologies have contributed considerably for food and nutritional security over the last few decades. Genetic engineering approaches are powerful tools that we have at our disposal to overcome substantial obstacles in the way of efficiency and productivity of current agricultural practices. Genome engineering via CRISPR/Cas9, Cpf1, base editing and prime editing, and OMICs through genomics, transcriptomics, proteomics, phenomics, an metabolomics have helped to discover underlying mechanisms controlling traits of economic importance. Principle and Practices of OMICs and Genome Editing for Crop Improvement provides recent research from eminent scholars from around the world, from various geographical regions, with established expertise on genome editing and OMICs technologies. This book offers a wide range of information on OMICs techniques and their applications to develop biotic, abiotic and climate resilient crops, metabolomics and next generation sequencing for sustainable crop production, integration bioinformatics, and multi-omics for precision plant breeding. Other topics include application of genome editing technologies for food and nutritional security, speed breeding, hybrid seed production, resource use efficiency, epigenetic modifications, transgene free breeding, database and bioinformatics for genome editing, and regulations adopted by various countries around globe for genome edited crops. Both OMICs and genome editing are vigorously utilized by researchers for crop improvement programs; however, there is limited literature available in a single source. This book provides a valuable resource not only for students at undergraduate and postgraduate level but also for researchers, stakeholders, policy makers, and practitioners interested in the potential of genome editing and OMICs for crop improvement programs.
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