Experimental Models of Parkinson`s Disease, House, Patrick

Автор: Cristina Sampaio, Christopher G. Goetz...
Название: Rating Scales in Parkinson`s Disease Clinical Practice and Research
ISBN: 0199783101 ISBN-13(EAN): 9780199783106
Издательство: Oxford Academ
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Описание: Parkinson Disease (PD) has been present. However the understanding of all intricacies of rating scales development was not widely available and the first attempts were relatively crude. In 2002, the Movement Disorders Society created a task force to systemize the measurement of Parkinson's Disease. Since then, the Task Force has produced and published several critiques to the available rating scales addressing both motor and non-motor domains of Parkinson Disease. Additionally the task force initiated a project to develop a new version of the UPDRS, the MDS-UPDRS. But none of this was made available in one convenient source. Until now. Rating Scales in Parkinson's Disease: Clinical Practice and Research is written for researchers from the medical and social sciences, and for health professionals wishing to evaluate the progress of their patients suffering from Parkinson's Disease. The book is both exhaustive in the description of the scales and informative on the advantages and limitations of each scale. As such, the text clearly guides readers on how to choose and use the instruments available. Extensive cross-referenced tables and charts closely integrate the parts of the book to facilitate readers in moving from one symptom domain to another. Features Based on a consistent and uniform methodology A clear consolidation of material otherwise only available in journals The first comprehensive book of its kind

Автор: Segura-aguilar, Juan (university Of Chile, Santiago, Chile)
Название: Clinical studies and therapies in parkinson`s disease
ISBN: 0128221208 ISBN-13(EAN): 9780128221204
Издательство: Elsevier Science
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Описание: Second novel in the chilling and epic new fantasy series from the bestselling and critically-acclaimed author of PRINCE OF THORNS and RED SISTER. `If you like dark you will love Mark Lawrence. And when the light breaks through and it all makes sense, the contrast is gorgeous` ROBIN HOBB

Автор: White Kate
Название: Encyclopedia of Parkinson`s Disease: Volume V (Models and Modules)
ISBN: 1632411938 ISBN-13(EAN): 9781632411938
Издательство: Неизвестно
Цена: 123380.00 T
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Описание: This book on Parkinson's disease (PD) elaborates the state-of-the-art research in the field. PD is caused mainly due to the death of dopaminergic neurons in the substantia nigra. Recent PD medications treat symptoms; though none decrease the rate of dopam

Автор: Shelton Helena
Название: Parkinson`s Disease: A Growing Concern
ISBN: 1632427168 ISBN-13(EAN): 9781632427168
Издательство: Неизвестно
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Автор: Falup-Pecurariu Cristian, Jenner Peter
Название: Autonomic Dysfunction in Parkinson`s Disease, 1
ISBN: 0323851223 ISBN-13(EAN): 9780323851220
Издательство: Elsevier Science
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Autonomic dysfunction is one of the most prevalent non-motor symptoms that occurs in Parkinson's disease. Autonomic Dysfunction in Parkinson's Disease provides up to date information on this important topic, which affects quality of life of these patients. This include a large number of domains: orthostatic hypotension, excessive sweating, dry eyes, constipation, weight loss, increased sensitivity to heat and cold, sexual dysfunction.

Название: Focus on parkinson`s disease research
ISBN: 1594549249 ISBN-13(EAN): 9781594549243
Издательство: Nova Science
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Описание: Parkinson`s disease was first described in 1817 by James Parkinson. It is a progressive, neurological disease mainly affecting people over the age of 50, although at least 10 per cent of cases occur at an earlier age. This book brings together the research in this field.

Автор: Ronald Chow, Jaclyn Viehweger, Michael Borean, Drew Hollenberg, Joav Merrick
Название: Parkinsons Disease: Awareness Among Young Adults
ISBN: 1536127450 ISBN-13(EAN): 9781536127454
Издательство: Nova Science
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Описание: Parkinsons disease, first described by the English surgeon James Parkinson (1755-1824) in 1817 as shaking palsy, is a neurodegenerative disorder that manifests symptoms such as resting tremor, muscular rigidity, bradykinesia and postural instability. These motor disorders have been extensively researched resulting in improved diagnostic accuracy and the development of robust rating scales and treatment strategies for symptoms. The treatment options for Parkinsons disease are similar to those for Alzheimers disease, meaning that at this moment in time there does not exist a definitive cure that can reverse the progression of the disease. Young adults seem to be well aware of Alzheimers disease, but are they aware of Parkinsons disease? Both of these diseases will become increasingly more prevalent in our aging world and young adults need to be prepared to care for family members who are struck by one, or both, diseases. In this book we document the assessment of the knowledge of young adults with respect to Parkinsons disease across the globe.

Автор: Yongxia Zhou
Название: Joint Imaging Applications in General Neurodegenerative Disease: Parkinsons, Frontotemporal, Vascular Dementia and Autism
ISBN: 1536194352 ISBN-13(EAN): 9781536194357
Издательство: Nova Science
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Цена: 89750.00 T
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Описание: Multiple advanced neuroimaging applications in various neurodegenerative diseases including Parkinsons disease (PD), frontotemporal dementia (FTD), vascular dementia (VaD) and autism spectrum disorder (ASD) are covered in this book. Relatively novel techniques such as integrated PET/MRI and independent component analysis (ICA)-based dual regression (DR) methods were developed to capture multi-level molecular/functional and structural/microstructural as well as high-order inter-network coordination abnormalities. For instance, both PET dopamine transporter and striatal binding ratio reductions in the caudate and putamen were found in PD, consistent with the diffusion tensor imaging (DTI) fractional anisotropy (FA) reduction and fMRI voxel-mirrored homotopic correlation (VMHC) in the substantia nigra (swallow tail sign signature of PD). Furthermore, dopamine storage and pathway labeled with the vesicular monoamine transporter tracer identified decreased densities in the bilateral mesial temporal cortex, caudate, orbitofrontal cortex, left frontal and occipital cortices, consistent with the morphological atrophy, functional connectivity and conductivity deficits in PD. Similarly in FTD patients, the advanced MRI methods such as ICA-DR, VMHC, voxel-based morphometry (VBM) as well as PET tracer for amyloid accumulation and FDG glucose uptake identified typical brain atrophy, structural dis-connectivity, glucose hypometabolism, higher neuropathological burden, lower interhemispheric correlation as well as disrupted intra- and inter-network modulation in the orbitofrontal and anterior temporal cortices together with insular and frontoparietal networks, with the cerebellum and dorsolateral attentional network as typical compensations. Functional and structural abnormalities had further been elucidated in the VaD dependent participants and autistic children. For instance, both lower FA and VMHC, brain atrophy and functional connectivity deficits, demyelination, axonal degeneration and white matter integrity damage in several white matter tracts were present in the dependent compared to independent participants in VaD data cohort. Increased neuronal activity with higher global fractional amplitude of low frequency fluctuation (fALFF) in the conventional and slow-wave sub-band was confirmed with less efficiency of systematic integration in VaD dependent group. Moreover, in ASD compared to controls, regional gray matter volume and cortical thickness in all four brain lobes increased, whereas white matter volume were decreased in addition to the lower temporal, visual and superior frontal but higher inferior and dorsolateral prefrontal cortical functional connectivities exhibited in ASD. The differences in each type of disease could also be revealed with the same imaging method based on either unique region or distinct brain circuit inter-connection, using VMHC, ICA-DR, DTI, VBM, fALFF and graph-theory based small-worldness analysis. In this book, we have developed and generalized conventional and advanced imaging methodologies to several common neurodegenerative diseases. For instance, we have identified the unique imaging signature for each disease type and the underlying neuropathological mechanism connections with conductivity, structural and microstructural connectivity, intra- and inter-network correlation, systematic integration and efficiency analyses. Our objective, comprehensive and confirmative results indicated great potential in utilizing these quantifications for accurate disease classification and staging. With solid imaging evidence, thorough analysis and generalized applications, this book should capture the interests of readers in the broad fields of brain science, disease diagnosis and effective treatment.

Автор: White Kate
Название: Encyclopedia of Parkinson`s Disease: Volume I (Etiology and Pathophysiology)
ISBN: 163241189X ISBN-13(EAN): 9781632411891
Издательство: Неизвестно
Цена: 156590.00 T
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Описание: The current book represents an elaborated study of the etiology and pathophysiology of Parkinson's disease, which is a complex neurological disorder. In this book, the ecological and biological agents which become the cause of Parkinson's disease have bee

Автор: Verstreken, Patrik
Название: Parkinson`s Disease
ISBN: 0128037830 ISBN-13(EAN): 9780128037836
Издательство: Elsevier Science
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Цена: 74620.00 T
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Описание: Parkinson’s Disease: Molecular Mechanisms Underlying Pathology explores the molecular pathways at the basis of the cellular defects connected to Parkinson’s disease, the second most common neurodegenerative disease, and the most common movement disorder. This book presents the latest research on the pathways and mechanisms that have been discovered to play a role in Parkinson's pathology. . This focus on mechanisms rather than individual genes allows the contributors to elaborate on overlapping and joint functions of different causative genes.Readers will find descriptions of model systems that present parallels (and differences) between discoveries in different species, demonstrating the importance of multidisciplinary research that spans a broad array of technologies and model organisms. Written from both a cross-methodology and cross-species perspective, the book provides readers with the current state of knowledge on the molecular biology of Parkinson’s.

Автор: Kotian
Название: Diffusion Tensor Imaging and Fractional Anisotropy
ISBN: 9811950008 ISBN-13(EAN): 9789811950001
Издательство: Springer
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Цена: 74530.00 T
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Описание: The book covers all aspects of one of the most advanced magnetic resonance imaging techniques, namely Diffusion Tensor Imaging (DTI) and Fractional Anisotropy (FA) values in early Parkinson’s disease (PD) patients. It provides step-by-step descriptions of DTI and its use in the early diagnosis of Parkinson’s disease by using FA values at several grey and white matter regions of the brain with helpful MRI DTI images. It includes clear flow charts with MRI DTI imaging protocol for Parkinson’s disease to aid in early diagnosis and treatment. The book covers essential information on anatomy and pathology in Parkinson’s disease and includes dedicated chapters on diffusion tensor imaging and FA in Parkinson’s disease. Additionally, it covers the role of magnetic resonance imaging in Parkinson’s disease with routine findings for Parkinson’s disease in MRI, followed by advanced imaging biomarkers and predictors in Parkinson’s disease. The book will assist the practitioners in the early detection of Parkinson’s disease using specific imaging biomarkers with the help of FA values, which will help in the early treatment of PD patients and thus extend and improve their quality of life. It will also be relevant for MD radiology, M.Sc. medical imaging technology students/trainees and Ph.D. medical imaging graduates as well as B.Sc MIT students.

Автор: Goyal Vinay
Название: Amantadine In Parkinson`S Disease An Expert Opinion
ISBN: 9390595614 ISBN-13(EAN): 9789390595617
Издательство: JayPee Brothers India
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Цена: 34270.00 T
Наличие на складе: Нет в наличии.
Описание:

Amantadine is used to treat the symptoms of Parkinson's disease (a disorder of the nervous system that causes difficulties with movement, muscle control, and balance) and other similar conditions. It is also used to control movement problems that are a side effect of certain medications used to treat Parkinson's disease (MedlinePlus).