Neurotoxicity Of Drugs Of Abuse,8, Costa, Lucio G.

Автор: Kostrzewa
Название: Handbook of Neurotoxicity
ISBN: 3031150791 ISBN-13(EAN): 9783031150791
Издательство: Springer
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Цена: 1118030.00 T
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Описание: This handbook is a reference source for identifying, characterizing, instructing on use, and describing outcomes of neurotoxin treatments – to understand mechanisms associated with toxin use; to project outcomes of neurotoxin treatments; to gauge neurotoxins as predictors of events leading to neurodegenerative disorders and as aids to rational use of neurotoxins to model disease entities. Neuroprotection is approached in different manners including those 1) afforded by therapeutic agents – clinical and preclinical; or 2) by non-drug means, such as exercise. The amorphous term ‘neurotoxin’ is discussed in terms of the possible eventuality of a neuroprotectant producing an outcome of excess neuronal survival and a behavioral spectrum that might produce a dysfunction – akin to a neurotoxin’s effect. This new edition significantly expands on the information provided in the first edition, providing the latest research in neurotoxicity and highlighting the relationship between specific neurotoxins and the neurodegenerative disorders they can cause. It also includes new sections on the neurotoxicity of heavy metals, fungi, and snake venom. The Handbook of Neurotoxicity is thus an instructive and valuable guide towards understanding the role of neurotoxins/neurotoxicity in the expansive field of Neuroscience, and is an indispensable tool for laboratory investigators, neuroscientists, and clinical researchers.

Автор: Costa,Lucio G.
Название: Neurotoxicity Of Halogenated Organic Compounds,10
ISBN: 0443133409 ISBN-13(EAN): 9780443133404
Издательство: Elsevier Science
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Цена: 168430.00 T
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Автор: Aschner, Michael
Название: Neurotoxicity Of Pesticides,4
ISBN: 0128205156 ISBN-13(EAN): 9780128205150
Издательство: Elsevier Science
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Цена: 178540.00 T
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Описание:

Neurotoxicity of Pesticides, Volume Four, in this comprehensive serial addresses contemporary advances in neurotoxicology of pesticides by providing authoritative review articles on key issues in the field. Edited by leading subject experts, topics of note in this new release include Organophosphates, OPs, Nerve agents, Pyrethroids, Neonicotinoids and Formamidines, among others.

Автор: Giovanni Laviola; Simone Macr?
Название: Adaptive and Maladaptive Aspects of Developmental Stress
ISBN: 1489985700 ISBN-13(EAN): 9781489985705
Издательство: Springer
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Цена: 174130.00 T
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Описание: Benefiting professors, researchers and advanced students who study neurological toxicity and disease, this book gathers cutting edge research on the impact of stress on development. Will also interest neurologists, psychiatrists, and other clinicians.

Автор: Jolanta B. Zawilska
Название: Synthetic Cathinones
ISBN: 3030087697 ISBN-13(EAN): 9783030087692
Издательство: Springer
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Цена: 139750.00 T
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Описание: Over the last decade, and particularly during the recent five years, a rapidly increasing number of novel psychoactive substance (NPSs), often marketed as “designer drugs”, “legal highs”, “herbal highs”, “research or intermediate chemicals” and “laboratory reagents”, has appeared on the drug market in an effort to bypass controlled substance legislation. NPSs encompass a wide range of different compounds and drug classes but had been dominated by synthetic cannabinomimetics and psychostimulatory synthetic cathinones, so-called ?-keto amphetamines. Compounds from the later class were first detected in Europe in 2004, and since then 103 new cathinones have been identified and reported to the European Monitoring Centre for Drugs and Drug Addiction, with 57 during the last two years. Synthetic cathinones – novel addictive and stimulatory psychoactive substances is the first publication of this kind that provides readers with background on chemical structures, detection, prevalence and motivation of use of the very popular group of NPSs. This book also presents comprehensive overview of the mechanisms of action, pharmacological activity, and main metabolic pathways of synthetic cathinones, followed by a detailed discussion of the acute and chronic toxicity associated with the use of these substances. Written by international experts in the field, this multi-authored book is a valuable reference not only for scientists, clinicians and academics, but also for readers representing different professional background who are involved in educational-prophylactic activities directed to harm reduction of psychoactive compounds.

Автор: Richard M. Kostrzewa
Название: Handbook of Neurotoxicity
ISBN: 1461458358 ISBN-13(EAN): 9781461458357
Издательство: Springer
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Цена: 464920.00 T
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Описание: Here is an instructive and valuable guide towards understanding the role of neurotoxins/neurotoxicity in the expansive field of Neuroscience. It is an indispensable tool for laboratory investigators, neuroscientists, and clinical researchers.

Автор: Qiao Niu
Название: Neurotoxicity of Aluminum
ISBN: 9811313695 ISBN-13(EAN): 9789811313691
Издательство: Springer
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Цена: 107130.00 T
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Описание: This book reviews the scientific literature and the authors’ own research linking aluminum neurotoxicity with cognitive impairment and Alzheimer’s disease (AD). It focuses on aluminum levels in the brain, region-specific and subcellular distribution, and its relation to neurofibrillary tangles and amyloid beta. Further, the book stresses the importance of aluminum’s complex speciation chemistry in relation to biology, and details aluminum’s mechanism in oxidative stress and cell death, especially in connection with apoptosis and necroptosis. The electrophysiological variation and synaptic plasticity induced by aluminum are covered, while the metal’s debatable role in AD and the cross-talk between aluminum and genetic susceptibility are also discussed. In closing, the book reviews the neurotoxic effects of aluminum and its important role in the pathogenesis of AD. Given its depth of coverage, the book provides readers with a systematic summary of aluminum neurotoxicity.

Автор: C. Winder
Название: The Developmental Neurotoxicity of Lead
ISBN: 9401089663 ISBN-13(EAN): 9789401089661
Издательство: Springer
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Цена: 81050.00 T
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Описание: Over the past two millennia environmental lead levels have risen dramatically (Patterson, 1980). Beginning in the late 1960s, evidence began to accumulate suggesting that lead at relatively low levels of exposure might be causing negative effects on neurobiological function.

Автор: Reglodi Dora, Tamas Andrea
Название: Pituitary Adenylate Cyclase Activating Polypeptide -- Pacap
ISBN: 3319817329 ISBN-13(EAN): 9783319817323
Издательство: Springer
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Цена: 186330.00 T
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Описание: Part 1. Evolutionary Aspects of PACAP.- 1. Molecular evolution of Pituitary adenylyl cyclase-activating polypeptide subfamily and cognate receptor subfamily.- 2. Occurrence, distribution and physiological function of pituitary adenylyl cyclase-activating polypeptide in invertebrates species.- 3. PACAP-like compounds of earthworms: identification and putative functions from embryonic development to brain regeneration.- 4. PACAP and learning in invertebrates.- Part 2. Effects of PACAP in Neuronal Development.- 5. PACAP and Neural Progenitor cells.- 6. PACAP and neural development.- 7. PACAP modulates distinct neuronal components to induce cell-specific plasticity at central and autonomic synapses.- Part 3. PACAP Receptors and Signalling.- 8. The pharmacophoric determinants of PACAP.- 9. PACAP-derived carriers: mechanisms and applications.- 10. Effects and development of TAT-tagged PACAP/VIP and related peptides.- Part 4. Presence and Physiological Functions of PACAP in Diverse Systems.- 11. Presence and role of PACAP in endocrine glands of mammals.- 12.Distribution of PACAP in the mammalian nervous system.- 13. Multiple mechanisms contribute to the PAC1 modulation of parasympathetic cardiac neuron excitability.- 14. PACAP in the circadian timing system - learning from knockout models.- 15. The role of PACAP in the regulation of body temperature.- Part 5. Presence and Functions of PACAP in the Gastrointestinal and Urinary Tracts.- 16. PACAP Regulation of gastrointestinal function and obesity.- 17. Protective intestinal effects of pituitary adenylate cyclase activating polypeptide.- 18. Renoprotective effects of pituitary adenylate cyclase-activating polypeptide 38 (PACAP38).- 19. Neuroplasticity of PACAP expression and function in micturition reflex pathways.- Part 6. Functions of PACAP in the Skeletal System.- 20. Role of PACAP and VIP signalling inregulation of chondrogenesis and osteogenesis.- 21. Role of PACAP/VIP in bone and joint physiology and pathophysiology.- Part 7. PACAP in the Regulation of the Reproductive System.- 22. Role of PACAP and its PACAP type I receptor in the central control of reproductive hormones.- 23. Occurrence and functions of PACAP in the placenta.- 24. PACAP in the reproductive system.- Part 8. PACAP in Biological Barriers and Barrier-Forming Cells.- 25. Transport of Pituitary Adenylate Cyclase Activating Polypeptide across the Blood-brain Barrier: Consequences for Disease States and Therapeutic Effects.- 26. Effects of PACAP on biological barriers.- 27. Role of PACAP in astrocytes and astrocytic tumors.- 28. Multiple actions of pituitary adenylate cyclase-activating polypeptide (PACAP) in Schwann cell biology.- Part 9. PACAP in Sensory Systems.- 29. Sniffing Out a Role for PACAP in the Olfactory System.- 30. Retinoprotective effects of PACAP.- 31. Pituitary adenylate cyclase activating polypeptide in the auditory system.- Part 10. Neuroprotective effects of PACAP.- 32. PACAP signaling in neuroprotection.- 33. PACAP expression and plasticity in the peripheral nervous system.- 34. The neuropeptide PACAP, a potent disease modifier candidate for brain stroke treatment.- Part 11. PACAP in the Pathomechanism of Migraine and Pain.- 35. Pituitary adenylate cyclase activating polypeptide (PACAP) in migraine pathophysiology.- 36. PACAP regulation of vascular tone: differential mechanism among vascular beds.- 37. PACAP circuits mediating the sensory and behavioral consequences of pain.- Part 12. Role of PACAP in Inflammatory Processes.- 38. PACAP modulation of CNS and peripheral inflammation.- 39. PACAP regulation of inflammatory and free radical networks in neuronal and non-neuronal diseases.- 40. Immunobiology of the pituitary adenylate cyclase-activating peptide.- Part 13. PACAP in Stress and Mood Disorders.- 41. PACAPergic synaptic signaling and circuitry mediating mammalian responses to psychogenic and systemic stressors.- 42. Using PACAP heterozygous mice as models of the three hit the

Автор: Hans Herken; Ferdinand Hucho
Название: Selective Neurotoxicity
ISBN: 3540578153 ISBN-13(EAN): 9783540578154
Издательство: Springer
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Цена: 81050.00 T
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Описание: This reference provides information on the cellular and subcellular targets of neurotoxins and their mode of action on the level of ion-channels, receptors and neurotransmitters. It concentrates on the use of bacterial toxins as a tool in neuroscientific research.

Автор: Norbert M?ller; Aye-Mu Myint; Markus J. Schwarz
Название: Immunology and Psychiatry
ISBN: 3319136011 ISBN-13(EAN): 9783319136011
Издательство: Springer
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Цена: 149060.00 T
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Описание: Psychiatric disorders are one of the most dramatic burdens for humankind. The role of immune dysfunction in the pathophysiology of these disorders has emerged during the last years, because there has been tremendous progress in psychoneuroimmunological research. Many results are presented here by pioneers in the field. The book addresses various effects of the immune system on the pathophysiology and course of psychiatric disorders and highlights the possible future impact on treatment decisions of various psychiatric disorders, including schizophrenia and depression. The contributions cover the role of in utero immune challenges on the development of schizophrenia, the role of infections, and autoimmune diseases and mild immune activation in the development of depression and schizophrenia, the influence of immune responses in other disorders such as Tourette's, Alzheimer's, and OCD, the connections between mental and physical pain as well as between anti-inflammatory and antipsychotic drugs.

Автор: Keith A. Foster
Название: Clinical Applications of Botulinum Neurotoxin
ISBN: 1493955985 ISBN-13(EAN): 9781493955985
Издательство: Springer
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Цена: 139310.00 T
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Описание: Currently, there are tremendous advances being made in understanding the basic science of both the structure and function of botulinum neurotoxins.