The definitive textbook on the chemical analysis of pharmaceutical drugs - fully revised and updated
Introduction to Pharmaceutical Analytical Chemistry enables students to gain fundamental knowledge of the vital concepts, techniques and applications of the chemical analysis of pharmaceutical ingredients, final pharmaceutical products and drug substances in biological fluids. A unique emphasis on pharmaceutical laboratory practices, such as sample preparation and separation techniques, provides an efficient and practical educational framework for undergraduate studies in areas such as pharmaceutical sciences, analytical chemistry and forensic analysis. Suitable for foundational courses, this essential undergraduate text introduces the common analytical methods used in quantitative and qualitative chemical analysis of pharmaceuticals.
This extensively revised second edition includes a new chapter on chemical analysis of biopharmaceuticals, which includes discussions on identification, purity testing and assay of peptide and protein-based formulations. Also new to this edition are improved colour illustrations and tables, a streamlined chapter structure and text revised for increased clarity and comprehension.
Introduces the fundamental concepts of pharmaceutical analytical chemistry and statistics
Presents a systematic investigation of pharmaceutical applications absent from other textbooks on the subject
Examines various analytical techniques commonly used in pharmaceutical laboratories
Provides practice problems, up-to-date practical examples and detailed illustrations
Includes updated content aligned with the current European and United States Pharmacopeia regulations and guidelines
Covering the analytical techniques and concepts necessary for pharmaceutical analytical chemistry, Introduction to Pharmaceutical Analytical Chemistry is ideally suited for students of chemical and pharmaceutical sciences as well as analytical chemists transitioning into the field of pharmaceutical analytical chemistry.
A comprehensive introduction for scientists engaged in new drug development, analysis, and approvals
Each year the pharmaceutical industry worldwide recruits thousands of recent science graduates--especially chemistry, analytical chemistry, pharmacy, and pharmaceutical majors--into its ranks. However, because of their limited background in pharmaceutical analysis most of those new recruits find making the transition from academia to industry very difficult. Designed to assist both recent graduates, as well as experienced chemists or scientists with limited regulatory, compendial or pharmaceutical analysis background, make that transition, Pharmaceutical Analysis for Small Molecules is a concise, yet comprehensive introduction to the drug development process and analysis of chemically synthesized, small molecule drugs. It features contributions by distinguished experts in the field, including editor and author, Dr. Behnam Davani, an analytical chemist with decades of technical management and teaching experience in compendial, regulatory, and industry.
This book provides an introduction to pharmaceutical analysis for small molecules (non-biologics) using commonly used techniques for drug characterization and performance tests. The driving force for industry to perform pharmaceutical analyses is submission of such data and supporting documents to regulatory bodies for drug approval in order to market their products. In addition, related required supporting studies including good laboratory/documentation practices including analytical instrument qualification are highlighted in this book.
Topics covered include:
Drug Approval Process and Regulatory Requirements (private standards)
Pharmacopeias and Compendial Approval Process (public standards)
Common methods in pharmaceutical analysis (typically compendial)
Common Calculations for assays and impurities and other specific tests
Analytical Method Validation, Verification, Transfer
Specifications including how to handle out of specification (OOS) and out of trend (OOT)
Impurities including organic, inorganic, residual solvents and elemental impurities
Good Documentation Practices for regulatory environment
Management of Analytical Laboratories
Analytical Instrument Qualifications including IQ, OQ, PQ and VQ
Due to global nature of pharmaceutical industry, other topics on both regulatory (ICH) and Compendial harmonization are also highlighted.
Pharmaceutical Analysis for SmallMolecules is a valuable working resource for scientists directly or indirectly involved with the drug development process, including analytical chemists, pharmaceutical scientists, pharmacists, and quality control/quality assurance professionals. It also is an excellent text/reference for graduate students in analytical chemistry, pharmacy, pharmaceutical and regulatory sciences.
Автор: Jin-Ming Lin Название: Cell Analysis on Microfluidics ISBN: 9811053936 ISBN-13(EAN): 9789811053931 Издательство: Springer Рейтинг: Цена: 167700.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book presents a detailed overview of the design, formatting, application, and development of microfluidic chips in the context of cell biology research, enumerating each element involved in microfluidics-based cell analysis, discussing its history, status quo, and future prospects, It also offers an extensive review of the research completed in the past decade, including numerous color figures. The individual chapters are based on the respective authors' studies and experiences, providing tips from the frontline to help researchers overcome bottlenecks in their own work. It highlights a number of cutting-edge techniques, such as 3D cell culture, microfluidic droplet technique, and microfluidic chip-mass spectrometry interfaces, offering a first-hand impression of the latest trends in the field and suggesting new research directions. Serving as both an elementary introduction and advanced guidebook, the book interests and inspires scholars and students who are currently studying microfluidics-based cell analysis methods as well as those who wish to do so.
Автор: John Greaves Название: Mass Spectrometry for the Novice ISBN: 1420094181 ISBN-13(EAN): 9781420094183 Издательство: Taylor&Francis Рейтинг: Цена: 80630.00 T Наличие на складе: Нет в наличии. Описание:
With usage of mass spectrometry continually expanding, an increasing number of scientists, technicians, students, and physicians are coming into contact with this valuable technique. Mass spectrometry has many uses, both qualitative and quantitative, from analyzing simple gases to environmental contaminants, pharmaceuticals, and complex biopolymers. The extraordinary versatility can make mass spectrometers daunting to novices. Consequently, new users would benefit greatly from an understanding of the basic concepts as well as the processes that occur in these instruments. Mass Spectrometry for the Novice provides exactly that, with detailed, straightforward descriptions and clear illustrations of principles of operations and techniques.
The book begins with an overview that includes essential definitions and then provides information on the components of and the strategies used in the most common instruments. The authors discuss the methodologies available, classes of compounds analyzed, and the types of data that can be generated. A group of representative applications from published articles is summarized, demonstrating the diversity of mass spectrometry. The authors also condense the essentials of the topic into one invaluable chapter that provides a set of concise take-home messages on all aspects of mass spectrometry. The final section provides a collection of resources including books, reviews, and useful websites. Using simple language, new color figures, clever cartoons, and assuming no prior knowledge, this book provides a readily understandable entr e to mass spectrometry. A CD-ROM with selected figures and cartoons is included.
Автор: Vladimir A. Krasnopolsky Название: Spectroscopy and Photochemistry of Planetary Atmospheres and Ionospheres: Mars, Venus, Titan, Triton and Pluto ISBN: 1107145260 ISBN-13(EAN): 9781107145269 Издательство: Cambridge Academ Рейтинг: Цена: 83430.00 T Наличие на складе: Поставка под заказ. Описание: This book provides a detailed overview of the fundamental principles and methods of spectroscopy and photochemical modeling for studying the chemical composition of planetary atmospheres and ionospheres. With detailed reviews of Mars, Venus, Titan, Triton and Pluto, it is a valuable reference for graduate students, researchers and planetary scientists.
Название: Fourier transform infrared spectroscopy (ftir) ISBN: 1536103837 ISBN-13(EAN): 9781536103830 Издательство: Nova Science Рейтинг: Цена: 83410.00 T Наличие на складе: Невозможна поставка. Описание: Fourier Transform Infrared (FTIR) spectroscopy applies the principle that molecular vibrations can absorb infrared radiation in the range of the electromagnetic radiation. This book discusses methods and provides new research on FTIR. Chapter One reviews the advances in the analysis of biological systems by means of FTIR spectroscopy. Chapter Two studies the last advances of infrared spectroscopy applied to the analysis of lignocellulosic materials. Chapter Three presents the Fourier transform infrared spectroscopic, coupled with chemometric tools, to characterize organic matter transformations during the composting process. Chapter Four focuses on applications of FTIR spectroscopy in the wine industry.
Автор: Suzanne Nielsen Название: Food Analysis Laboratory Manual ISBN: 3319441256 ISBN-13(EAN): 9783319441252 Издательство: Springer Рейтинг: Цена: 60550.00 T Наличие на складе: Нет в наличии. Описание: This third edition laboratory manual was written to accompany Food Analysis, Fifth Edition, by the same author. New to this third edition of the laboratory manual are four introductory chapters that complement both the textbook chapters and the laboratory exercises.
Автор: Koen H. A. Janssens Название: Microscopic X-Ray Fluorescence Analysis ISBN: 0471974269 ISBN-13(EAN): 9780471974260 Издательство: Wiley Рейтинг: Цена: 385390.00 T Наличие на складе: Поставка под заказ. Описание: -XRF analysis is a recently developed, highly sensitive analytical technique. This topical publication provides a detailed overview of the applications of -XRF in industrial and academic circles.
Автор: Boyd, Robert K. Bethem, Robert Basic, Cecila Matth Название: Trace quantitative analysis by mass spectrometry ISBN: 0470057718 ISBN-13(EAN): 9780470057711 Издательство: Wiley Рейтинг: Цена: 106600.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: Quantitative Chemical Analysis by Mass Spectrometry provides a serious introduction to the subject of mass spectrometry, providing the reader with the tools and information to be well prepared to perform such demanding work in a real-life laboratory.
Автор: Nail Fatkullin; Takayuki Ikehara; Hiroshi Jinnai; Название: NMR · 3D Analysis · Photopolymerization ISBN: 3662145553 ISBN-13(EAN): 9783662145555 Издательство: Springer Рейтинг: Цена: 191560.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This series presents critical reviews of the present and future trends in polymer and biopolymer science including chemistry, physical chemistry, physics and materials science. Impact Factor Ranking: Always number one in Polymer Science.
Автор: Mikhail Brik, Ma Chong-Geng Название: Theoretical Spectroscopy of Transition Metal and Rare Earth Ions: From Free State to Crystal Field ISBN: 9814800562 ISBN-13(EAN): 9789814800563 Издательство: Taylor&Francis Рейтинг: Цена: 118410.00 T Наличие на складе: Невозможна поставка. Описание: This book describes in detail the main concepts of theoretical spectroscopy of transition metal and rare-earth ions. It shows how the energy levels of different electron configurations are formed and calculated for the ions in a free state and in crystals.
Автор: Simona Francese Название: Emerging Technologies for the Analysis of Forensic Traces ISBN: 303020541X ISBN-13(EAN): 9783030205416 Издательство: Springer Рейтинг: Цена: 111790.00 T Наличие на складе: Есть у поставщика Поставка под заказ. Описание: This book provides a line of communication between academia and end users/practitioners to advance forensic science and boost its contribution to criminal investigations and court cases. By covering the state of the art of promising technologies for the analysis of trace evidence using a controlled vocabulary, this book targets the forensics community as well as, crucially, informing the end users on novel and potential forensic opportunities for the fight against crime. By reporting end users commentaries at the end of each chapter, the relevant academic community is provided with clear indications on where to direct further technological developments in order to meet the law requirements for operational deployment, as well as the specific needs of the end users. Promising chemistry based technologies and analytical techniques as well as techniques that have already shown to various degrees an operational character are covered. The majority of the techniques covered have imaging capabilities, that is the ability to visualize the distribution of the target molecules within the trace evidence recovered. This feature enhances intelligibility of the information making it also accessible to a lay audience such as that typically found with a court jury. Trace evidence discussed in this book include fingermarks, bodily fluids, hair, gunshot residues, soil, ink and questioned documents thus covering a wide range of possible evidence recovered at crime scenes.
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